A5032745390- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Formal Methods in Verification
- Cancer-related molecular mechanisms research
- Petri Nets in System Modeling
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- RNA regulation and disease
- Forensic and Genetic Research
- Real-Time Systems Scheduling
- Genomics and Chromatin Dynamics
University of Nottingham
2021-2023
MRC Laboratory for Molecular Cell Biology
2022
University College London
2022
Tecnológico de Monterrey
2001-2015
Abstract Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local synapses. The synaptic tagging hypothesis has previously been proposed explain how mRNAs are available at specific activated However is regulated, transcripts silenced or processed as part of the process still unknown. Modification by N6-methyladenosine (m 6 A/m) influences cellular fate mRNA. Here, advanced microscopy, we showed that m A demethylation eraser protein...
Abstract Aims N 6 ‐methyladenosine modification of RNA (m A) regulates translational control, which may influence neuronal dysfunction underlying neurodegenerative diseases. Methods Using microscopy and a machine learning approach, we performed cellular profiling m A‐RNA abundance YTHDF1/YTHDF3 A reader expression within four regions the human brain from non‐affected individuals with Parkinson's disease, dementia Lewy bodies or mild cognitive impairment (MCI). Results In non‐diseased tissue,...
Brain-derived neurotrophic factor (BDNF) promotes neuronal differentiation and survival is implicated in the pathogenesis of many neurological disorders. Here, we identified a novel intergenic enhancer located 170 kb from Bdnf gene, which expression transcript variants during mouse activity. Following activation, enhancer-promoter contacts increase, region moves away repressive nuclear periphery. activity necessary for clustering dendritogenesis vitro, cortical development vivo. Our findings...
STRs are powerful tools intensively used in forensic and kinship studies.In order to assess the effectiveness of non-CODIS genetic markers paternity tests, composition six mini short tandem repeats-mini-STRs-(D1S1656, D2S441, D6S1043, D10S1248, D12S391, D22S1045) microsatellite SE33 Mestizo Amerindian populations from Mexico were studied.Using multiplex polymerase chain reactions capillary electrophoresis, this study genotyped all loci 870 chromosomes evaluated statistical parameters.All...