A5017666606- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Epilepsy research and treatment
- Erythropoietin and Anemia Treatment
- Potassium and Related Disorders
- Drug Transport and Resistance Mechanisms
- Magnesium in Health and Disease
- Blood Pressure and Hypertension Studies
- Vitamin D Research Studies
- Central Venous Catheters and Hemodialysis
- Pharmacy and Medical Practices
- Innovations in Medical Education
- Infectious Encephalopathies and Encephalitis
- Metabolism and Genetic Disorders
- Heart Rate Variability and Autonomic Control
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Drug-Induced Hepatotoxicity and Protection
- Esophageal and GI Pathology
- Intracerebral and Subarachnoid Hemorrhage Research
University of Illinois Chicago
1999-2022
University at Buffalo, State University of New York
1978-2016
IS practice
1985-2014
Kaiser Permanente
2012
Towa Pharmaceutical (Japan)
2011
Kyushu Rosai Hospital
1988-2004
University of Illinois Urbana-Champaign
1987-1992
Hospital for Sick Children
1990
American Association of Colleges of Pharmacy
1986-1987
Illinois College
1987
The roles and contributions of pharmacists in Shanghai during the coronavirus disease 2019 (COVID-19) pandemic are described this report. Five have been appointed as members an expert interdisciplinary health care team tasked with taking all adult patients COVID-19 a designated hospital, Public Health Clinical Center (SPHCC). They work at SPHCC, having responsibilities that include drug supplies, dispensing, pharmacy intravenous admixture services (PIVAS), prescription audits, medication...
Summary: Purpose: To evaluate the pharmacokinetics and safety of multiple oral doses tiagabine HC1 in subjects with different degrees hepatic impairment. Methods: Four mild impairment, three moderate six matched normal received twice daily HCl for 5.5 days. Serial blood specimens were obtained 48 h after final dose. Total unbound plasma concentrations determined by high‐performance liquid chromatography (HPLC) ultrafiltration, respectively. Pharmacokinetic parameters compared between groups...
Although the hypotensive effects of food ingestion during hemodialysis have been documented, hemodynamic mechanism is unclear. It could be decreased cardiac output due to splanchnic sequestration or vascular resistance vasorelaxation. Also, caffeine, which block postprandial hypotension in elderly, not studied a dialysis setting. Central hemodynamics were monitored by thoracic electric bioimpedance 10 patients who ingested test meal 1 h into dialysis. All ultrafiltration was done initial 2...
Phosphate binders such as calcium salts or sevelamer, a cationic polymer, can markedly reduce absorption of oral ciprofloxacin. This randomized, open-label, two-way, crossover study examined the influence cation lanthanum on systemic ciprofloxacin exposure after administration.Twelve patients randomly received in manner single dose 750 mg alone and plus carbonate 1 g three times daily with meals for six doses, washout interval 7 to 14 d. Serial blood urine samples were collected 24 h...
The aim of this study was to evaluate the prevalence and clinical correlates nonalcoholic fatty liver disease (NAFLD) in children Chinese immigrants.NAFLD is increasing frequently identified children. High rates NAFLD were found adult immigrants. However, there are limited data regarding American children.Clinical laboratory collected from 407 children, aged 6 18 years, who had routine office visits at a Chinatown medical practice. Children classified as having suspected if common causes...
The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent found to be significantly lower (1.99 ± 1.49 ml/min per kg) with total serum bilirubin concentrations >1.5 mg/100 ml than ≤1.5 (3.57 1.72 kg; P < 0.001). Serum protein binding cirrhotic (42.2 6.8% bound) normal adults (53.1 5.2% bound; Low also the premature neonates (32.4 8.2% Reduced implies need for a therapeutic range concentration (3.5 13.9 μg/ml) compared...
A new method for the analysis of serum chloramphenicol by reversed-phase, high-performance liquid chromatography (HPLC) is described. The involves a preliminary extraction 0.1 ml with ethyl acetate containing an internal standard, reversed-phase C18 microparticulate column acetonitrile-acetate buffer mobile phase, and detection measuring UV absorbance at 270 nm. Assay performance was compared existing microbiological assay. HPLC demonstrated both increased precision sensitivity. specificity...
Benefits of early nephrology care are well-established, but as many 40% U.S. patients with end-stage renal disease (ESRD) do not see a nephrologist before its onset. Our objective was to evaluate the effect proactive, population-based oversight (PPNO) on chronic kidney (CKD) progression.Retrospective control analysis Kaiser Permanente Hawaii members CKD using propensity score matching methods. We matched 2,938 and case pairs individuals stage 3a for pre-PPNO period (2001-2004) post-PPNO...
The pharmacokinetics of metronidazole was evaluated in eight patients with alcoholic liver disease. Metronidazole (7.5 mg/kg) administered to each patient intravenously. Serial blood samples were obtained after the dose. Serum concentrations determined by high-performance liquid chromatography. following pharmacokinetic parameters (mean +/- standard deviations) obtained: half-life, 18.31 6.06 h; elimination rate constant, 0.042 0.013 h-1; volume distribution, 0.77 0.16 liters/kg; and total...
Amphotericin is the drug of choice for treatment fungal infections in infants and children. When used recommended doses, amphotericin therapy associated with high rates adverse effects, including nephrotoxicity, hepatotoxicity, decrease white blood cells, platelets hemoglobin, chills, fever even death (1). We report a case involving neonate who was exposed to 50 fold overdose over three day period.
Cephalosporins are used with increasing frequency for sepsis treatment in patients receiving CAVU and CAVH. The different cephalosporins share the same basic molecular structure, yet they exhibit varied extent of plasma protein binding. Different amounts antibiotics may be removed by ultrafiltration procedure because these variations physicochemical properties. We evaluated sieving eight new across hemofilter membrane using an vitro model. Bovine blood was perfused through polysulfone...
Abstract In Thailand during the early 1990s, there was a need for an increased number of pharmacists and expansion their knowledge skills to address nation. Leaders Thai pharmacy education community at time crafted long‐term plan aiming expand educator workforce national scale through financial support Royal Government. This led establishment United States‐Thai Consortium Development Pharmacy Education in 1994. The aim advance leading U.S. schools using both short‐term trainings. Twenty plus...
The increased incidence of vascular access thrombosis (VAT) associated with recombinant human erythropoietin (r-HuEPO) therapy is multifactorial and controversial. Sixty-three hemodialysis patients who received > or = 12 weeks r-HuEPO were prospectively followed for the VAT. Those experienced VAT (Group 1) compared those did not 2). initially 50 U/kg intravenously three times a week. dose was adjusted target hematocrit (t-Hct) 30-33%. Twenty-five 63 (40%) 1). These older (mean, 54.0 +/- 14.0...
Metronidazole is now being used with increasing frequency for various infectious conditions in patients renal failure. It commonly administered to septic who have developed acute failure requiring hemodialysis. The hemodialysis clearances of metronidazole and its metabolites were evaluated nine on maintenance mean +/- standard deviation clearance the extraction ratio 106.9 16.3 ml/min 0.65 0.08, respectively, when regenerated cellulose dialysis membrane was used. use cuprophan 72.1 17.3 0.44...
Summary Phenytoin is frequently used to treat seizure episodes in critically ill patients. Some of these patients have acute renal failure, requiring continuous hemofiltration help maintain fluid and solute balance. We evaluated the removal phenytoin who received drug while undergoing treatment. Arterial ultrafiltrate sample pairs were collected for concentration determination. The concentrations almost identical free serum concentrations. Thus ultrafiltrate/arterial ratios resembled...
Recent studies have demonstrated a cytoprotective effect of sucralfate on gastric mucosa in patients receiving aspirin. The potential drug interaction between and aspirin was evaluated randomized crossover manner 12 healthy men. Subjects were initially given single dose alone or combination with for 2 days. dosing schedule then reversed after 1 week. Sixteen blood samples drawn each HPLC assay its metabolites. Pharmacokinetic parameters calculated aspirin, salicylic acid, salicyluric acid....
When selecting anti-hypertensives, most physicians do not consider daily blood pressure (BP) variation. To evaluate the effectiveness of anti-hypertensives on temporal profile BP, we proposed three new parameters obtained by ambulatory BP monitoring and evaluated these comparing 5 mg amlodipine 40 nifedipine coat-core. Hypobaric values were determined subtracting data collected before administration drug from those after treatment at corresponding time day. The hypobaric curve was drawn...
Abstract Lanthanum carbonate, a chewable noncalcium‐containing phosphorus (P) binder, is useful for treating secondary hyperparathyroidism in patients who have hypercalcemia and cannot swallow whole tablets. However, some chew tablets or prefer to crush mix them with food. This study was conducted determine the P‐binding efficacy of crushed lanthanum compare it chewed hemodialysis (HD) patients. After 1‐week washout period, 11 (7 men, 4 women) were randomized receive, crossover fashion, 1000...