A5079992026- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vascular Malformations Diagnosis and Treatment
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Hepatitis Viruses Studies and Epidemiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Multiple Sclerosis Research Studies
- Dermatological and COVID-19 studies
- Liver Disease and Transplantation
- Dental Research and COVID-19
- Property Rights and Legal Doctrine
- HIV/AIDS oral health manifestations
- Autoimmune and Inflammatory Disorders Research
- Intensive Care Unit Cognitive Disorders
- biodegradable polymer synthesis and properties
- Systemic Lupus Erythematosus Research
- Infectious Encephalopathies and Encephalitis
- Vagus Nerve Stimulation Research
- Infection Control in Healthcare
- Marine and Offshore Engineering Studies
Universidade Federal do Estado do Rio de Janeiro
2022-2024
Universidade do Estado do Rio de Janeiro
2024
Universidade Federal do Rio de Janeiro
2013-2023
Fundação Oswaldo Cruz
2018-2022
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood. Evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein or fragments released from cells during infection, reaching different tissues, including the CNS, irrespective of presence viral RNA. Here, we demonstrate brain infusion mice has a late impact on cognitive function,...
Abstract It is well known the potential of severe acute respiratory coronavirus type 2 (SARS-CoV-2) infection to induce post-acute sequelae, a condition called Long COVID. This syndrome includes several symptoms, but central nervous system (CNS) main one neurocognitive dysfunction. Recently it has been demonstrated relevance plasma levels neurofilament light chain (pNfL), as biomarker early involvement CNS in COVID-19. The aim this study was investigate relationship between pNfL patients...
In 2019, a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is transmitted via the airborne route, caused new pandemic namely, “coronavirus disease 2019” (COVID-19). Although effectiveness of face masks to prevent transmission SARS-CoV-2 debated, no study has evaluated virus-blocking efficacy used by patients. We aimed evaluate this SARS-CoV-2-infected individuals. Data, used, and nasopharyngeal swab samples were obtained from these Forty-five paired swabs processed;...
Abstract Background Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence in patients COVID-19 and determined if coinfection is poorer outcomes neurological symptoms. Methods We analyzed samples 53 diagnosed COVID-19. The were evaluated for presence alphaherpesviruses, betaherpesviruses, gammaherpesviruses, viral loads quantified using quantitative polymerase chain reaction...
The antibiotic cotrimoxazole was associated with poly(lactic acid‐ co ‐glycolic acid) (PLGA) and maghemite, aiming to reach a controlled drug release system. PLGA synthesized through the polycondensation of lactic acid glycolic in an equimolar ratio, maghemite coprecipitation method. inserted composite three different procedures: solution, fusion, situ check best insertion Several techniques were used characterize materials. copolymer characterized by nuclear magnetic resonance...
SARS-CoV-2 can trigger autoimmune central nervous system (CNS) diseases in genetically susceptible individuals, a mechanism poorly understood. Molecular mimicry (MM) has been identified other viral as potential triggers of CNS events. This study investigated if MM is the process through which induces breakdown immune tolerance. The frequency disorders was evaluated prospective cohort with patients admitted to COVID-19 Intense Care Unity (ICU) Rio de Janeiro. Then, an silico analysis...
Since COVID-19 was declared a pandemic, Brazil has become one of the countries most affected by this disease. A year into second wave emerged, with rapid spread new SARS-CoV-2 lineage concern. Several vaccines have been granted emergency-use authorization, leading to decrease in mortality and severe cases many countries. However, emergence variants raises alert for potential waves transmission an increase pathogenicity. We compared demographic clinical data critically ill patients infected...
Hepatitis B virus (HBV) is one of the leading causes acute and chronic hepatitis represents a serious public health threat. Cytokines are important chemical mediators that regulate differentiation, proliferation, function immune cells, with accumulating evidence indicating inadequate responses responsible for elimination or persistence HBV. This study aimed to determine cytokine profiles (IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A) during HBV infection investigate their association...
Transcriptome studies have reported the dysregulation of cell cycle-related genes and global inhibition host mRNA translation in COVID-19 cases. However, key cellular mechanisms that are most affected by severe outcome this disease remain unclear. For work, RNA-seq approach was used to study differential expression buffy coat cells two groups people infected with SARS-CoV-2: (a) Mild, mild symptoms; (b) SARS (Severe Acute Respiratory Syndrome), who were admitted intensive care unit outcome....
To assess the prevalence of hepatitis E virus (HEV) RNA and antibodies among kidney transplant recipients (KTR) in Central Brazil. The presence chronic HEV infection was also investigated.A cohort study conducted 316 KTR treated at a referral center for transplantation Goiânia, All serum samples were tested (real-time PCR) anti-HEV IgG/IgM (ELISA). Anti-HEV-positive confirmed using an immunoblot test. chronicity investigated subgroup patients with elevated alanine aminotransferase (ALT...
Abstract Few studies showed that neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tubulin-associated unit (TAU), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) may be related to neurological manifestations severity during after SARS-CoV-2 infection. The objective of this work was investigate the relationship among nervous system biomarkers (NfL, TAU, GFAP, UCH-L1), biochemical parameters, viral loads with heterogeneous outcomes in a cohort severe COVID-19...
To investigate molecular mimicry (MM) between severe acute respiratory coronavirus type 2 (SARS-CoV-2) antigens and human autoantigens related to cognitive impairment in long COVID the relationship plasma levels of neurofilament light chain (pNfL) patients with neurocognitive symptoms.
Human herpesviruses (HHVs) can establish latency and be reactivated, also are neurotropic viruses that trigger neurological disorders. HHV-6 is a herpesvirus associated with Studies have reported the detection of in patients COVID-19 manifestations. However, specific diagnoses disorders caused by these tend to invasive or difficult interpret. This study aimed relationship between miRNA manifestations co-infected evaluate miRNAs as potential biomarkers. Serum samples from three cohorts were...
SARS-CoV-2 can trigger autoimmune central nervous system (CNS) diseases in genetically susceptible individuals, a mechanism poorly understood. Molecular mimicry (MM) has been identified other viral as potential triggers of CNS events. This study investigated if MM is the process through which induce breakdown immune tolerance. The frequency disorders was evaluated prospective cohort with patients admitted COVID-19 Intense Care Unity (ICU) Rio de Janeiro. Then, an silico analysis performed to...
To improve RT‐qPCR with an internal control and a synthetic standard curve to detect HEV in HIV co‐infected patients. A single‐stranded RNA (ssRNA) double‐stranded DNA (dsDNA) were designed, compared the international reference panel for genotypes, tested quantify genotypes. The detection limit of (50 copies per ml) was better than (100 WHO (250 ml). Then, 280 serum samples from HIV‐positive patients RNA, which detected 3·6% samples. viral load ranged 2 × 102 ml 4·78 108 ml. IgM/IgG...
<title>Abstract</title> It is well known the potential of severe acute respiratory coronavirus type 2 (SARS-CoV-2) infection to induce post-acute sequelae, a condition called Long COVID. This syndrome includes several symptoms, but central nervous system (CNS) main one neurocognitive dysfunction. Recently it has been demonstrated relevance plasma levels neurofilament light chain (pNfL), as biomarker early involvement CNS in COVID-19. The aim this study was investigate relationship between...
To assess the efficacy of washing cloth masks, we simulated SARS-CoV-2 contamination in tricoline fabric and tested decontaminants to reduce viral particles. Viral suspensions using two variants (B.1.1.28 P.1) were inoculated these fabrics, inactivation kinetics evaluated after with various household disinfection products (Soap powder, Lysoform®, Hypochlorite sodium 70% Alcohol), rinse numbers, exposure times. Afterward, fabrics washed sterile water, RNA was extracted amplified RT-qPCR....
ABSTRACT Biological behavior of Cerebral Cavernous Malformation (CCM) is still controversial without clear-cut signature for biological mechanistic explanation lesion aggressiveness. There plenty evidence implicating dysregulated inflammatory and immune responses in vascular malformation pathogenesis, including CCM. In the present study, we evaluated predictive capacity SNPs VDR rs7975232 , rs731236 rs11568820 as well expanded analysis PTPN2 rs72872125 FCGR2A rs1801274 relation to aggressive...
<title>Abstract</title> Biological behavior of Cerebral Cavernous Malformation (CCM) is still controversial without clear-cut signature for biological mechanistic explanation lesion aggressiveness. There plenty evidence implicating dysregulated inflammatory and immune responses in vascular malformation pathogenesis, including CCM. In the present study, we evaluated predictive capacity...
Abstract Introduction: Multiple sclerosis is an autoimmune cause of neurological disability. Among its risk factors, it may be related to viral triggers. The advent COVID-19 raises concern as a novel CNS autoimmunity, which response virus antigens. In this context, we present case highly active multiple onset two weeks after SARS-CoV2 mRNA vaccination. Case description: A young woman had lower limb paresthesia quickly evolved into tetraplegia. She oligoclonal bands on CSF, with cervical...