A5016584252- Endometriosis Research and Treatment
- Pregnancy-related medical research
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Transport and Resistance Mechanisms
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Nerve injury and regeneration
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- GDF15 and Related Biomarkers
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Menstrual Health and Disorders
- Intestinal and Peritoneal Adhesions
- CAR-T cell therapy research
- Peroxisome Proliferator-Activated Receptors
- Ovarian function and disorders
- Endometrial and Cervical Cancer Treatments
- Inflammasome and immune disorders
- Whipple's Disease and Interleukins
- Cholesterol and Lipid Metabolism
Airlangga University
2020-2025
Universitätsklinikum Würzburg
2020-2022
Max Planck Institute for Infection Biology
2016-2018
Charité - Universitätsmedizin Berlin
2018
Antigen-specific neuroinflammation and neurodegeneration are characteristic for neuroimmunological diseases. In Parkinson's disease (PD) pathogenesis, α-synuclein is a known culprit. Evidence α-synuclein-specific T cell responses was recently obtained in PD. Still, causative link between these dopaminergic had been lacking. We thus addressed the functional relevance of immune PD mouse model. utilized model which an Adeno-associated Vector 1/2 serotype (AAV1/2) expressing human mutated...
Polycystic ovary syndrome (PCOS) is the most common endocrinology disorder affecting women of reproductive age, characterized by irregular menstruation, androgen overproduction and insulin resistance. Peroxisome proliferator-activated receptor-gamma (PPARG) one essential modulators ovarian steroid hormone synthesis lipid metabolism. Precision medicine targeted therapy have emerged as practical therapeutic approaches, focusing on specific molecules/pathways to minimize side effects improve...
Pelvic pain, often associated with endometriosis, significantly affects women's quality of life. This study explored the soluble neural cell adhesion molecules (sNCAM), interleukin 2 receptor α (sIL-2Rα), and IL-2 levels in serum peritoneal fluid infertile women pelvic pain. We enrolled 86 aged 24 to 41 years undergoing diagnostic laparoscopy: 44 endometriosis 42 who acted as controls. Pain intensity was assessed using visual analog scale. The were measured enzyme-linked immunosorbent assay....
Abstract Mycobacterium tuberculosis ( Mtb ) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member the family, IL-36, was recently shown to be involved cellular defense against . To unveil underlying mechanism IL-36 induced antibacterial activity, we analyzed its role regulation cholesterol metabolism, together with involvement Liver X Receptor (LXR) this process. We...
Tuberculosis remains a major killer worldwide, not the least because of our incomplete knowledge protective and pathogenic immune mechanism. The roles interleukin 1 (IL-1) 18 pathways in host defense are well established, as their regulation through inflammasome complex. In contrast, 36γ (IL-36γ), recently described member IL-1 family, its immunological relevance remain largely unknown. Here we show that Mycobacterium tuberculosis infection macrophages induces IL-36γ production...
Abstract Problem Soluble immune checkpoint molecules constitute the emerging novel mediators in regulation. Their role pathogenesis of endometriosis has not been fully addressed. In this study, we aimed to investigate relationship between clinical manifestation endometriosis‐associated infertility and level four soluble checkpoints: sCTLA4, sHLA‐G, sPD‐1, sPD‐L1. Method study The concentrations serum peritoneal fluid from 88 patients who underwent laparoscopy were evaluated by enzyme‐linked...
To evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-12p70 levels in serum peritoneal fluid women related to infertility pelvic pain.Eighty-seven were diagnosed with endometriosis or cases infertility. IL-1β, determined by enzyme-linked immunosorbent assay (ELISA). Pain assessment was evaluated the Visual Analog Scale (VAS) score.Serum IL-6 increased compared control group. Serum IL-8 correlated VAS scores infertile women. A positive correlation also found between IL-1β score. significant...
Introduction: TNF-α, LT-α, and sCD40L belong to the TNF superfamily play a pivotal role in chronic inflammatory disease. Yet, these soluble molecules are largely unexplored endometriosis cases with infertility. The present study aimed evaluate serum peritoneal fluid levels of correlate its level severity. Methods: Peripheral blood samples were obtained from 87 infertility who underwent laparoscopy, consisting 44 endometriotic women 43 non-endometriotic women. determined using ELISA. Results:...
<b><i>Objectives:</i></b> Myeloid cell-derived factors contribute to the immunopathology of endometriosis. Soluble CD14 (sCD14), CD163 (sCD163), and MIF serve as in vivo markers myeloid function. However, these soluble molecules are largely unexplored women with endometriosis-related infertility cases. We investigated three markers, namely sCD14, sCD163, MIF, cases associated endometriosis correlated its level stage <b><i>Design:</i></b>...
Endometriosis is a chronic inflammatory disease characterized by endometrial-like tissue outside the uterus. Molecules linked to natural killer (NK) and cytotoxic T cells, including granulysin (GNLY), MHC class I-related chain A (MICA), perforin (PRF1) support immune surveillance, though their roles in endometriosis remain unclear. This study investigates association of these molecules with clinical parameters infertile women endometriosis.
Abstract Aim An accumulating body of evidence suggests the involvement alpha-synuclein (aSyn) specific autoreactive T cells in Parkinson’s disease (PD). Here, we investigate whether novel antigen-specific tolerance-inducing biomolecules, that present peptide antigens on MHC class Ib-related molecules, can inhibit neurodegeneration and prevent PD vivo. Methods The alpha3 domain human Ib molecule HLA-G inhibits via ILT-2 or murine PIRB receptor. We fused this to I alpha1-alpha2 antigen...