A5061869471- Hemoglobinopathies and Related Disorders
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Iron Metabolism and Disorders
- Obsessive-Compulsive Spectrum Disorders
- Infant Development and Preterm Care
- Pharmacological Effects and Toxicity Studies
- Child Nutrition and Feeding Issues
- Neuroscience of respiration and sleep
- Neural and Behavioral Psychology Studies
- Neonatal and fetal brain pathology
- Sleep and related disorders
- Educational and Psychological Assessments
- Autism Spectrum Disorder Research
- Childhood Cancer Survivors' Quality of Life
- Genetics and Neurodevelopmental Disorders
- Neuroscience, Education and Cognitive Function
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Reading and Literacy Development
- Child Nutrition and Water Access
- Fetal and Pediatric Neurological Disorders
- Stuttering Research and Treatment
- Innovation Policy and R&D
- Cardiovascular Effects of Exercise
University College Dublin
2006-2024
Great Ormond Street Hospital
2017-2018
University College London
2014-2018
New York University Press
2018
Cambridge University Press
2018
International Society of Nephrology
2018
Botsford Hospital
2010
Beaumont Hospital, Dearborn
2010
Mater Misericordiae University Hospital
2006
Greenville College
1994
To determine whether multiple subpial transection in the posterior temporal lobe has an impact on long-term outcome children who have drug-resistant Landau-Kleffner syndrome (LKS) or other "electrical status epilepticus during sleep" (ESES)-related regression. Given wide variability outcomes reported literature, a secondary aim was to explore predictors of outcome.The current study includes surgery group (n = 14) comprising patients underwent and nonsurgery comparison 21) presurgical...
There is an increasing need to identify and treat sleep disturbances in Tourette syndrome (TS), a neurodevelopmental condition characterized by tics. This study explored sleep, tics, executive functioning children with TS (n=136) neurotypical controls (n=101) through parent-report scales open-ended questions. 85% of scored the clinical range for disorder. Higher tic severity predicted increased difficulties. Qualitative insights indicated bidirectional link between which warrants...
In addition to pain, sickle cell anaemia (HbSS) complications include neurocognitive difficulties in attention and processing speed associated with low daytime night-time oxygen saturation compounded by obstructive sleep apnoea (OSA). the general population OSA is treated continuous positive airways pressure (CPAP). The aim of this single-blind, randomised, controlled phase II trial compare auto-adjusting CPAP (APAP) standard care alone individuals HbSS determine whether intervention...
Abstract Snoring and poor sleep may affect cognition, particularly in young children with chronic conditions. Parents of London preschoolers sickle cell anemia (SCA; n = 22), matched controls (n 24), unselected typically developing 142) completed questionnaires. Preschoolers SCA had significantly more problems when compared to the larger population. occurred at least one two nights a week for 79% group. This is 25% 33% Randomized controlled trials improve already at‐risk cognitive...
Abstract. Previous analyses of response time distributions have shown that the Stroop effect is observed in mode (μ) and standard deviation (σ) normal part distribution, as well its tail (τ). Specifically, interference related to semantic processes has been suggested specifically affect tail, respectively. However, only one study literature directly manipulated interference, none manipulating interference. The present research aims address this gap by both a manual task, examining how these...
The aim of this mixed-methods study was to gain an insight through qualitative and quantitative means into the impact coronavirus disease 2019 (COVID-19) pandemic on children with without Tourette syndrome (TS).
Children with sickle cell anemia (SCA) are commonly reported to experience executive dysfunction. However, the development of function (EF) in preschool-age children without stroke this patient population has not been investigated so it is unclear when and how these deficits emerge.This case-control study examines feasibility assessing early functioning 22 preschool years SCA domains processing speed, working memory, attention, inhibitory control, cognitive flexibility, as well everyday...
Objective: The aim of this study was to establish the utility NIH Toolbox as a cognitive screener executive functions in clinical context. Additionally, we aimed investigate whether age and time on transfusion were related function performance. Method: Twenty-eight children adolescents with sickle cell anemia (SCA) between 8 18 years (M = 13.28, SD 3.05) treatment included. Participants completed five tasks (three two non-executive control tasks). Results: Mean scores one three measures...
Sickle cell disease (SCD) is a genetic red blood disorder that often leads to stroke and executive dysfunction in school-age children adults. This study aimed characterize the development of neural correlates selective attention, an early component function, preschool with SCD.Auditory event-related potentials (ERPs) were recorded while attended story stream one ear ignored second other interchangeably. In total, 12 patients (mean age = 5.5, 7 males) 22 typically developing 4.4, 10 included...
Executive deficits are commonly reported in children with sickle cell anemia. Earlier identification of executive would give more scope for intervention, but this cognitive domain has not been routinely investigated due to a lack age-appropriate tasks normed preschool children. In particular, information relating patient performance on an task that reflects everyday activity the classroom could provide important insight and practical recommendations teacher at key developmental juncture as...
There is increasing recognition of the high prevalence sleep issues in children with Tourette syndrome (TS), a condition characterised by motor and vocal tics. Overnight polysomnography (PSG) has been primary mode assessment TS literature, despite extensive use actigraphy other neurodevelopmental populations. As result, there are existing research gaps surrounding day-to-day variability links to daytime functioning. This study adopts naturalistic, intensive longitudinal design examine while...
Executive functioning (EF) skills are crucial for young students to meet academic and social demands at school. EF skill development is particularly amenable environmental influences in the early years. In classroom settings, teachers play a vital role providing support promote these skills. Research limited regarding teachers' understanding of domains recognition difficulties students. Additionally, experiences with managing neuropsychological reports that involve supports interventions...
Michelle Downesab*, Christine Bergc, Fenella J Kirkhamb, Laura Kischkelb, Imogen McMurrayb & de Haanba School of Psychology, University College Dublin, Irelandb Developmental Neurosciences, UCL Great Ormond Street Institute Child Health, London, UKc Program in Occupational Therapy, Washington St. Louis, MO, USA
Sensory modulation difficulties are commonly reported in patients with ADHD, however there has been little focus on the development of these young children at a higher risk later ADHD diagnosis. This study investigated whether familial history show greater sensory difficulties. We also explored was linked to negative affectivity, which highlighted as potential early marker ADHD. Parents under 6 years family (n = 65) and no 122) completed questionnaires temperament. Children from families...
Aims Few studies have investigated the potential impact of sickle cell anaemia (SCA) on temperament. The aim current study was to investigate temperament in preschool children with SCA and establish reliability Children’s Behaviour Questionnaire (CBQ) this population. Methods CBQ, a parent-report measure temperament, completed by parents 21 control group typically developing children, matched for age, ethnicity socioeconomic status. Results A significant difference between groups identified...