A5059426519- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Urological Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Renal and Vascular Pathologies
- Esophageal Cancer Research and Treatment
- Adrenal and Paraganglionic Tumors
- Urinary Tract Infections Management
- Ureteral procedures and complications
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Urologic and reproductive health conditions
- Advanced X-ray and CT Imaging
- Cancer Genomics and Diagnostics
- Hernia repair and management
- Sexual function and dysfunction studies
Institute of Science Tokyo
2024-2025
Tokyo Medical and Dental University
2015-2025
Tokyo Metropolitan Institute of Medical Science
2025
The University of Tokyo
2024
Tokyo Medical and Dental University Hospital
2023
Tokyo Metropolitan Ohtsuka Hospital
2019-2023
Hamamatsu Medical Center
2012
To analyze the recent status of laparoscopic adrenalectomy for benign adrenal tumors, focusing on relationship between number surgeries and complication rates per facility.
Organoids are miniature organs developed through technology. Kidney organoids that originate from human inducible pluripotent stem cells (iPSCs) were to recreate renal diseases. However, it is impossible simultaneously produce kidney iPSCs of multiple individuals and in a single medium. We herein report the development adult tubular organoids, namely, "tubuloids," primary epithelial Kidneys eight patients who underwent nephrectomy due malignancy sectioned, tubule cultured; four had normal...
Pembrolizumab is the standard treatment for metastatic urothelial carcinoma (mUC) progressing after platinum-based chemotherapy.1 Predicting response to pembrolizumab may facilitate decision making and patient counseling. Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) used evaluate lesions in mUC,2 its role management of patients receiving unclear. For other cancers such as malignant melanoma or lung cancer, utility 18F-FDG PET/CT...
Background The effectiveness of immune checkpoint inhibitors (ICIs) as adjuvant therapy for muscle-invasive urothelial carcinoma (MIUC) with high recurrence risk has been demonstrated. With no direct efficacy comparisons available, we aimed to indirectly compare the and safety pembrolizumab, nivolumab, atezolizumab treatments high-risk MIUC based on individual patient data (IPD) from clinical trials. Methods IPD was reconstructed using Shiny method Kaplan–Meier curves eligible randomized...
Background/Objectives: Delta-radiomics involves analyzing feature variations at different acquisition time-points. This study aimed to assess the utility of delta-radiomics analysis applied contrast-enhanced (CE) and non-contrast-enhanced (NE) T1-weighted images (WI) in predicting therapeutic response chemoradiotherapy (CRT) patients diagnosed with muscle-invasive bladder cancer (MIBC). Methods: Forty-three non-metastatic MIBC (cT2–4N0M0) who underwent partial or radical cystectomy after...
The value of the Vesicle Imaging-Reporting and Data System (VI-RADS) in diagnosis muscle-invasive bladder cancer (MIBC) for urothelial carcinoma with variant histology (VUC) remains unknown. We retrospectively evaluated 360 consecutive patients (255 pure [PUC] 69 VUC) who underwent multiparametric magnetic resonance imaging between 2011 2019. VI-RADS scores assigned by four readers were significantly higher VUC group than PUC (p < 0.05). In cohort 122 pair-matched patients, there was no...
Objectives To evaluate the utility of magnetic resonance imaging (MRI) and MRI‐ultrasound fusion targeted biopsy (TB) for predicting unexpected extracapsular extension (ECE) in clinically localized prostate cancer (CLPC). Methods This study enrolled 89 patients with one or more lesions showing a Prostate Imaging‐Reporting Data System (PI‐RADS) score ≥3 but without morphological abnormality prostatic capsule on pre‐biopsy MRI. All underwent TB systematic followed by radical prostatectomy...
Cigarette smoking is an independent risk factor for vasculogenic erectile dysfunction (ED). Nitric oxide (NO) has been demonstrated to be the principal mediator of cavernous smooth muscle relaxation and penile erection. Therefore, we examined whether or not enzyme activities factors involved in NO generation pathway are affected rabbit corpus cavernosum after administration nicotine- tar-free cigarette smoke extract (CSE). CSE was prepared by bubbling a stream into phosphate-buffered saline....
Photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumors (TURBT) has emerged as a promising complementary tool to white light (WL) cystoscopy, potentially improving cancer detection and replacing conventional mapping biopsies. This study aimed investigate the diagnostic accuracy PDD by anatomical locations in biopsies through lesion-based analysis.
Purpose To investigate the value of computed (c) diffusion‐weighted imaging (DWI) in assessing prostate cancer aggressiveness. Materials and Methods Fifty‐five patients with peripheral zone who underwent prebiopsy 1.5T magnetic resonance (including native DWI at b ‐values 0 1000 s/mm 2 ) were included. cDWI signal intensities nonmalignant tissue measured. Association between changes monoexponentially calculated signals according to different primary Gleason grades assessed. Results The...
Postoperative inguinal hernia (IH) is one of the most common complications radical prostatectomy (RP) including robot-assisted RP (RARP). However, a procedure to prevent IH after RARP has not been established. We investigated impact processus vaginalis transection (PVT) and PVT with peritoneal closure on RARP.A retrospective analysis was performed data from patients who underwent at two tertiary hospitals in Japan, where subsequent introduced 2014. The incidence for 2 years compared among 79...
To analyze the incidence and risk factors of intraoperative hypotension related to photodynamic diagnosis-assisted transurethral resection bladder tumor (PDD-TURBT) with oral 5-aminolevulinic acid (5-ALA).
Objectives To determine the incidence and preoperative risk factors of post‐excisional hypoglycemia in patients undergoing pheochromocytoma resection. Methods Patients who underwent surgical resection at a single institution were retrospectively enrolled present study. The primary end‐point was development hypoglycemia; that is, serum glucose level <70 mg/dL. levels immunoreactive insulin during oral glucose‐tolerance test surgery analyzed to elucidate mechanism hypoglycemia. Results A...
Abstract In the pursuit of more accurate pathophysiological models for assessing renal drug response, development kidney organoids derived from human pluripotent stem cells represents a significant step forward. However, recapitulating aging/senescence-associated pathophysiology within these remains challenging. Here, we present an innovative approach to generate homogeneous epithelial-like structures known as “tubuloid” using primary proximal tubular epithelial (hRPTECs) cultured resected...