A5090007628- Antifungal resistance and susceptibility
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Oral microbiology and periodontitis research
- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- HIV/AIDS oral health manifestations
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Botulinum Toxin and Related Neurological Disorders
- Lung Cancer Research Studies
- Respiratory and Cough-Related Research
- Hepatitis C virus research
- Probiotics and Fermented Foods
- Bacterial Identification and Susceptibility Testing
- Dental Health and Care Utilization
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Advanced Drug Delivery Systems
- SARS-CoV-2 and COVID-19 Research
LabCorp (United States)
2023
University of Maryland, Baltimore
2014-2021
ABSTRACT Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity mortality tend to be challenging treat. Candida albicans Staphylococcus aureus specifically considered leading opportunistic fungal bacterial pathogens, respectively, mainly due their ability form biofilms on catheters indwelling medical devices. However, the impact of mixed-species biofilm growth therapy remains largely understudied. In this study,...
Biofilm-associated polymicrobial infections tend to be challenging treat. Candida albicans and Staphylococcus aureus are leading pathogens due their ability form biofilms on medical devices. However, the therapeutic implications of interactions in a host is largely unexplored. In this study, we used mouse subcutaneous catheter model for vivo-grown validate our vitro findings C. albicans-mediated enhanced S. tolerance vancomycin vivo. Comparative assessment recovery from catheters with...
ABSTRACT In microbial biofilms, microorganisms utilize secreted signaling chemical molecules to coordinate their collective behavior. Farnesol is a quorum sensing molecule by the fungal species Candida albicans and shown play central physiological role during biofilm growth. Our pervious in vitro vivo studies characterized an intricate interaction between C. bacterial pathogen Staphylococcus aureus , as these coexist biofilm. this study, we aimed investigate impact of farnesol on S....
The clinical significance of polymicrobial interactions, particularly those between commensal species with high pathogenic potential, remains largely understudied. Although the dimorphic fungal Candida albicans and bacterium Staphylococcus aureus are common cocolonizers humans, they considered leading opportunistic pathogens. Oral candidiasis specifically, characterized by hyphal invasion oral mucosal tissue, is most infection in HIV(+) immunocompromised individuals. In this study, building...
Oral candidiasis (OC), caused by the fungal pathogen Candida albicans, is most common opportunistic infection in HIV(+) individuals and other immunocompromised populations. The dramatic increase resistance to antifungals has emphasized importance of identifying unconventional therapeutic options. Antimicrobial peptides have emerged as promising candidates for intervention due their broad antimicrobial properties lack toxicity. Histatin-5 (Hst-5) specifically exhibited potent anticandidal...
Microbial species utilize secreted-signaling molecules to coordinate their behavior. Our previous investigations demonstrated a key role for the Candida albicans-secreted quorum-sensing molecule farnesol in modulating Staphylococcus aureus response antimicrobials mixed biofilms. In this study, we aimed provide mechanistic insights into impact of on S. within context inter-species interactions. To mimic biofilm dynamics, farnesol-sensitized cells were generated via sequential exposure. The...
Next-generation sequencing (NGS) is currently widely used for biomarker studies and molecular profiling to identify concurrent alterations that can lead the better characterization of a tumor's landscape. However, further evaluation technical aspects related detection gene rearrangements copy number warranted. There were 12 ALK rearrangement-positive tumor specimens from patients with non-small cell lung cancer (NSCLC) previously detected via fluorescence in situ hybridization (FISH),...
Among fungal species, Candida albicans is the one that most commonly causes human diseases, ranging from superficial to life-threatening systemic infections. As part of commensal microbiota, C. asymptomatically colonizes mucosal surfaces in healthy individuals. However, as an opportunistic microbe, any disruption host environment, including immune dysfunction, can lead proliferate and invade virtually site host.