A5059199895- Cancer Treatment and Pharmacology
- Brain Metastases and Treatment
- Advanced Breast Cancer Therapies
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Multiple and Secondary Primary Cancers
- HER2/EGFR in Cancer Research
- Total Knee Arthroplasty Outcomes
- Lung Cancer Treatments and Mutations
- Bone fractures and treatments
- Sports injuries and prevention
- Acute Myocardial Infarction Research
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Orthopedic Surgery and Rehabilitation
- Esophageal Cancer Research and Treatment
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer survivorship and care
- Muscle and Compartmental Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
Hospital de São João
2016-2024
Universidade do Porto
2023
Hospital Braga
2019
Centro Hospitalar de Entre o Douro e Vouga E.P.E.
2012-2018
CUF Porto Hospital
2016
Immune checkpoint inhibitors were approved for advanced nonsmall cell lung cancer (NSCLC) treatment. Despite improved survival, not all patients benefit from these agents. Here, the prognostic impact of pretreatment modified Glasgow Prognostic Score (mGPS) and neutrophil-to-lymphocyte ratio (NLR) was assessed. From 77 included, 83.2% received at least one prior systemic therapy. Immune-related adverse events (irAE) occurred in 20 patients. A lower mGPS associated with higher median overall...
Muehrckeâs lines (ML)âa rare presentation of apparent leukonychia1âwere firstly described by Dr. Robert Muehrcke2 in 1956 a subset patients with hypoalbuminemia due to nephrotic syndrome and other causes. They are usually associated periods metabolic stress hypoalbuminemia, such as those secondary infections, severe malnutrition, chronic diseases (e.g. liver diseases, renal insufficiency, or pellagra) chemotherapy drugs (most frequently doxorubicin cyclophosphamide).1,3,4 Other causes...
N/a.
Chemotherapy-induced nausea and vomiting (CINV) negatively impact cancer patients’ quality of life treatment outcomes. This study evaluated the achievement complete response to CINV prophylaxis during first five days after chemotherapy in adult outpatient clinics with solid malignant tumours receiving Moderate or Highly Emetogenic Chemotherapy (MEC HEC) Portugal. During study, patients completed three evaluations, severity on daily was assessed. A (no emetic episodes, no use rescue...
A small but important subset of patients with metastatic breast cancer has an oligometastatic disease. Some these are highly responsive to systemic therapy and have the potential achieve complete remission treatment. However, it remains be clarified best locoregional treatment strategy for such what features can determine whose candidates. We also don't know will role cyclin-dependent kinase 4/6 inhibitors in those cases. report case a 41-year-old woman HR-positive/HER2-negative who, after...
A 25-year-old man came to the emergency room after an inversion ankle sprain during a soccer game with friends. He was unable play injury but able walk. complained about lateral pain that rapidly increasing in intensity and spreading leg. At first physical examination, we found malleolus oedema normal almost painless dorsi plantar flexion, severe foot important weakness on eversion. initially managed medication leg elevation while waiting for imagological study. The plain X-ray CT showed no...
Abstract: Proximal tibiofibular joint (PTFJ) dislocation is a rare injury, accounting for less than 1% of all knee injuries. The mechanism this injury usually sports related. Diagnosis largely clinical, but the findings may be subtle. This condition easily missed. There no larger series described in literature only several cases PTFJ treated by different methods. We present two antero-lateral successfully with approaches.
Hoffa fractures are intra-articular of the distal femur in coronal plane, with an incidence approximately 0,65 % all femoral fractures. Isolated medial condyle even less frequently reported. The most frequent mechanism associated is axial load exerted on a flexed knee. Diagnosis this fracture might be challenging as standard radiographic studies may appear normal. Due to their location, anatomical reduction must achieved and articular congruence restored for patient achieve optimal...
(1) Background: Breast cancer (BC) has a high incidence in Europe, particularly older adults. Traditionally under-represented clinical trials, this age group is often undertreated due to ageism. This study aims characterize frail adults (≥70 years) with BC based on comprehensive geriatric assessment, guide individualized treatment decision-making. (2) Methods: A descriptive analysis of treated from January 2021 December 2022 was performed. Data were analyzed anonymized electronic medical...
Breast cancer (BC) patients treated with anthracyclines and/or anti-HER2-targeted therapies (AHT) are highly associated cardiovascular toxicity (CVT). Our objective was to evaluate the risk of CVT secondary treatment and role cardioprotective-drugs (CPD) in BC patients. We collected a retrospective cohort females chemotherapy AHT from 2017 2019. defined as LVEF<50% or decline ≥10% during follow-up. As CPD, we considered renin-angiotensin-aldosterone-system inhibitors beta-blockers. A...
Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It shown retrospective study that this association an independent predictive factor worse progression-free survival (PFS). Objective: To verify impact concomitant administration Ci on overall (OS) and PFS. Material Methods:...
Some ankle sprains hide important lesions beyond the classic lateral ligament complex injuries. The inverted osteochondral fracture of talus (LIFT) represents a rare lesion, whose diagnosis relies on high clinical suspicion followed by correct image study interpretation. We present successful arthroscopic fixation LIFT lesion in 45-year-old active man. At 8 months follow-up, patient was pain free and able to return his daily activities without limitation. imagiological showed fragment...
Introduction: Gastrointestinal stromal tumors (GIST), although very rare, are the most common mesenchymal neoplasms of gastrointestinal tract and develop in approximately 5–25% patients with neurofibromatosis type 1 (NF1). Neurofibromatosis 1-associated GIST (NF1-GIST) differ phenotypically genotypically from sporadic GIST, neither present receptor tyrosine kinase (KIT) or platelet-derived growth factor receptor-alfa (PDGFR-alfa) mutation have propensity to be multifocal occur small bowel....