A5102943647- Synthesis and bioactivity of alkaloids
- Berberine and alkaloids research
- DNA and Nucleic Acid Chemistry
- Botanical Research and Chemistry
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- RNA and protein synthesis mechanisms
- Fungal Plant Pathogen Control
- Drug Transport and Resistance Mechanisms
- Carbohydrate Chemistry and Synthesis
- Cell death mechanisms and regulation
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and biological activities of Ficus species
- Bioactive Compounds and Antitumor Agents
- Synthetic Organic Chemistry Methods
- Sulfur Compounds in Biology
- Synthesis and Biological Activity
- Photochemistry and Electron Transfer Studies
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Natural Compounds in Disease Treatment
- Plant Genetic and Mutation Studies
- Arsenic contamination and mitigation
- HIV/AIDS drug development and treatment
University of Kalyani
2012-2021
Indian Institute of Chemical Biology
2003-2012
Council of Scientific and Industrial Research
2011
Background Base dependent binding of the cytotoxic alkaloid harmalol to four synthetic polynucleotides, poly(dA).poly(dT), poly(dA-dT).poly(dA-dT), poly(dG).poly(dC) and poly(dG-dC).poly(dG-dC) was examined by various photophysical calorimetric studies, molecular docking. Methodology/Principal Findings Binding data obtained from absorbance according neighbor exclusion model indicated that constant decreased in order...
Abstract Background Diethylnitrosamine (DEN) promoted by carbon tetrachloride (CCl 4 ) forms DNA adducts inducing hepatocellular carcinoma (HCC). Plant alkaloid, harmalol, is being used as a therapeutic agent against HCC due to its accessibility and efficacy apoptosis inhibiting proliferation of cancer epithelial cells. Result Seven groups Swiss albino mice were taken. Different stages liver tissues serum from various experimental collected before after harmalol treatment. The investigation...
Abstract The work focuses towards interaction of harmaline, with nucleic acids different motifs by multispectroscopic and calorimetric techniques. Findings this study suggest that binding constant varied in the order single‐stranded (ss) poly(A) > double‐stranded calf thymus (CT) DNA poly(G)·poly(C) clover leaf tRNA Phe . Prominent structural changes ss poly(A), CT DNA, poly(G)· poly(C) concomitant induction optical activity bound achiral alkaloid molecule was observed, while , very weak...
The reaction of phenanthrene-9,10-dione with N-phenylbenzene-1,2-diamine in methanol the presence anhydrous CuCl2 and HCl affords a 9-phenyldibenzo[a,c]phenazin-9-ium cation, [1]+, as [1][CuCl2], good yields. [1][CuCl2] excess iodide salt [1][I]. formations [1][I] have been confirmed by elemental analyses, mass, IR, UV-vis 1H NMR spectra including single crystal X-ray structure determination [1][CuCl2]. DNA binding studies spectra, fluorescence circular dichroism hydrodynamic, isothermal...
New berberine analogue (BER-S), as a colorimetric probe in the absence of DNA and turn-on fluorometric presence towards S<sup>2−</sup> detection is reported.
Harmine exhibits pH dependent structural equilibrium and possesses numerous biological pharmacological activities. Mode mechanism of DNA binding its cytotoxicity were studied by multiple spectroscopic, calorimetric, molecular docking in vitro apoptotic as well vivo biochemical histological studies. It exists cationic (structure I) decationic form II) the range 3.0–7.8 8.5–12.4, respectively, with a pKa 8.0. Structure I at 6.8 binds strongly to cooperative mode Kiω 1.03 × 106 M−1and...
Nanocomposites based on bacterial cellulose in combination with osteogenic growth peptide for bone repair: cytotoxic, genotoxic and mutagenic evaluationsRaquel Mantuaneli Scarel-Caminagaa, Sybele Saskab, Leonardo Pereira Franchic, Raquel A. Santose, Ana Maria Minarelli Gaspara, Ticiana S.O. Capotea, Sidney José Lima Ribeirob, Younés Messaddeqb, Reinaldo Marchetto b, Catarina S. Takahashic d
Stable cadmium sulphide (CdS) nanoclusters have been synthesised in non-ionic surfactant vesicles (niosomes). The nanocluster characteristics show strong dependence on the Cd2+ precursor concentration. At low concentration, aggregates comprising fine nanocrystals of CdS with diameter 2–5 nm are formed. high concentrations, crystalline (15–20 diameter) Interestingly, these reside exclusively vesicular bilayer. Moreover, highly photoluminescent and exhibit cytotoxicity towards cancerous HeLa...
An alternate synthetic route to the important anticancer drug suberoylanilide hydroxamic acid (SAHA) from its α,ß-didehydro derivative is described. The didehydro obtained through a cross metathesis reaction between suitable terminal alkene and N -benzyloxyacrylamide. Some of derivatives SAHA were preliminarily evaluated for activity towards HeLa cells. administration analogues caused significant decrease in proliferation Furthermore, one showed maximum cytotoxicity with minimum GI 50 value...