A5084609791- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Advanced Memory and Neural Computing
- Biochemical effects in animals
- stochastic dynamics and bifurcation
- Urinary Tract Infections Management
- Neuroendocrine regulation and behavior
- Vestibular and auditory disorders
- Aldose Reductase and Taurine
- Photoreceptor and optogenetics research
- Earthquake and Disaster Impact Studies
- Nitric Oxide and Endothelin Effects
- Respiratory and Cough-Related Research
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Neuropeptides and Animal Physiology
- Urinary Bladder and Prostate Research
- Amino Acid Enzymes and Metabolism
Mita Hospital
2025
Tamagawa University
2014-2024
Université de Tours
2023
Inserm
2023
Tenri Hospital
2023
Japan Science and Technology Agency
2014-2017
3Brain (Switzerland)
2017
Kagawa University
2017
Czech Academy of Sciences, Institute of Geology
2012-2015
Fukuoka Prefecture Education Center
2015
The architectonic subdivisions of the brain are believed to be functional modules, each processing parts global functions. Previously, we showed that neurons in different regions operate firing regimes monkeys. It is possible reflect differences underlying information processing, and consequently homologous across animal species might similar. We analyzed neuronal spike trains recorded from behaving mice, rats, cats, regularity differed systematically, with one being greater than similar...
The stochastic mechanism of synchronous firing in a population neurons is studied from the point view information geometry. Higher-order interactions neurons, which cannot be reduced to pairwise correlations, are proved exist firing. In neuron pool where each fires stochastically, probability distribution q(r) activity r, fraction pool, studied. When has widespread distribution, particular, when two peaks, fire synchronously at one time and quiescent other times. generating such interesting...
The gene encoding the 49-kilodalton protein that undergoes light-induced phosphorylation in Drosophila photoreceptor has been isolated and characterized. encoded 401 amino acid residues a molecular mass of 44,972 daltons, it shares approximately 42 percent sequence identity with arrestin (S-antigen), which proposed to quench cascade guanosine 3',5'-monophosphate hydrolysis vertebrate photoreceptors. Unlike protein, however, arrestin, appears bind phosphorylated rhodopsin, not itself reported...
Cortical neurons of behaving animals generate irregular spike sequences. Recently, there has been a heated discussion about the origin this irregularity. Softky and Koch (1993) pointed out inability standard single-neuron models to reproduce irregularity observed sequences when model parameters are chosen within certain range that they consider be plausible. Shadlen Newsome (1994), on other hand, demonstrated leaky integrate-and-fire can if inhibition is balanced with excitation. Motivated...
In motor cortex, 2 types of deep layer pyramidal cells send their axons to other areas: intratelencephalic (IT)-type neurons specifically project bilaterally the cerebral cortex and striatum, whereas extratelencephalic (ET)-type, termed conventionally tract-type, ipsilaterally thalamus areas. Although they have totally different synaptic membrane potential properties in vitro, little is known about differences between them ongoing spiking dynamics vivo. We identified IT-type ET-type neurons,...
Two distinct motor areas, the primary and secondary cortices (M1 M2), play crucial roles in voluntary movement rodents. The aim of this study was to characterize laterality cortical representations right left forelimb movements. To achieve goal, we developed a novel behavioral task, Right-Left Pedal which head-restrained male rat manipulates or pedal with corresponding forelimb. This task enabled us monitor independent movements both forelimbs high spatiotemporal resolution. We observed...
Rodents have primary and secondary motor cortices that are involved in the execution of voluntary movements via their direct parallel projections to spinal cord. However, it is unclear whether rodent cortex has any function distinct from properly control movements. In present study, we quantitatively examined neuronal activity caudal forelimb area (CFA) rostral (RFA) head-fixed rats performing (pushing, holding, pulling a lever). We found virtually no major differences between CFA RFA...
Aim : Obsessive-compulsive disorder (OCD) is characterized by imbalanced reinforcement learning. This study investigated neural correlates of this imbalance examining resting-state functional connectivity (rs-fMRI) in non-medicated OCD patients and healthy controls (HCs) exhibiting varying degrees memory trace imbalance. Methods We employed network-based statistics (NBS), suitable for identifying network-level alterations rs-fMRI data from 49 53 HCs (Core Discovery Dataset: Core-DS) to...
Objective Spastic paraplegia 7 (SPG7) is an autosomal recessive neurodegenerative disorder caused by biallelic pathogenic variants in SPG7. It predominantly characterized adult-onset slowly progressive spastic paraparesis. While SPG7 presenting with ataxia or without spasticity relatively common Europe and North America, it considered rare Japan. This study aimed to identify patients among those undiagnosed within the Japanese population. Methods We retrospectively selected 351 ataxia,...
A 59-year-old man without risk factors for atherosclerosis was diagnosed with coronavirus disease 2019 (COVID-19). Four days later, he developed dysarthria and gait disturbance. Neurological examination revealed slurred speech, ataxia, mild cognitive decline. Brain magnetic resonance imaging multiple infarcts in the bilateral middle cerebellar peduncles leukoencephalopathy, indicating diagnosis of cerebral autosomal dominant arteriopathy subcortical leukoencephalopathy (CADASIL). Genetic...
A 79-year-old woman was diagnosed with Sjögren's syndrome (SjS) at the age of 73 years by lip biopsy, gum test, and salivary gland scintigraphy positive antinuclear (ANA), anti-centromere (ACA), negative anti-Ro/SS-A antibodies. Seven days before admission, patient developed gait disturbance, which progressed to difficulty in walking two admission. She hospitalized because subacute disturbance. Neurological examination showed disturbances characterized small steps, wide-based gait, left...
Climbing fibre responses (c.f.r.s) evoked by white matter stimulation and the depolarizations induced iontophoretically applied L-glutamate L-aspartate were recorded intracellularly from proximal dendrites of Purkinje cells in vitro slice preparations guinea-pig cerebellum. Short pulses dose-dependently depolarized cell dendrite. Even small doses these amino acids reduced input resistance. The maximum decrease resistance was 36% that 38%. Intracellular injection Cs+ allowed to be a range -15...
For the purpose of demonstrating action taurine as a neuromodulator in addition to its suggested neurotransmitter function, effects and muscimol on depolarization-induced Ca-dependent release [3H] gamma-aminobutyric acid ([3H]GABA) L-[3H]glutamate cerebellar slices from guinea pigs were investigated. The [3H]GABA was found be greatly decreased by GABA agonist, muscimol, taurine, but not glycine. little affected taurine. [3H]GABA, enhanced bicuculline strychnine, picrotoxin, suppressive...
Stereotaxic head fixation plays a necessary role in current physiological techniques, such as vivo whole cell recording and two-photon laser-scanning microscopy, that are designed to elucidate the cortical involvement animal behaviors. In rodents, however, often inhibits learning performance of behavioral tasks. particular, it has been considered inappropriate for head-fixed rodents be operantly conditioned perform skilled movements with their forelimb (e.g., lever-press task), despite...
The ability to make a correct choice of behavior from various options is crucial for animals' survival. neural basis the has been attracting growing attention in research on biological and artificial systems. Alternative tasks with variable ratio (VR) interval (VI) schedules reinforcement have often employed studying decision making by animals humans. In VR schedule task, alternative choices are reinforced different probabilities, subjects learn select behavioral response rewarded more...
ABSTRACT A new flow cytometry-based automated urine analyzer, the UF-50, was evaluated for its ability to screen samples significant bacteriuria. One hundred eighty-six specimens from patients attending an outpatient clinic of a university-based hospital were examined. The results obtained with UF-50 compared those by conventional quantitative culture. detected bacteriuria sensitivity 83.1%, specificity 76.4%, positive predictive value 62.0%, negative 90.7%, and accuracy 78.5%. These are...