A5063856078- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Spinal Cord Injury Research
- Disability Rights and Representation
- Wound Healing and Treatments
- Family and Disability Support Research
- Cancer Cells and Metastasis
- Bone fractures and treatments
- Cancer, Hypoxia, and Metabolism
Loughborough University
2018-2022
Keele University
2021
Abstract Background The effects of cryopreservation on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are still ill-defined. In this study, a quantitative approach was adopted to measure several post-thaw cell attributes in order provide an accurate reflection the freezing and thawing impact. Methods Fresh cryopreserved passage-matched from three different donors were discretely analysed compared for their viability, apoptosis level, phenotypic marker expression, metabolic...
Mesenchymal stem cells have been widely implicated in tumour development and metastases. Moving from the use of two-dimensional (2D) models to three-dimensional (3D) investigate this relationship is critical facilitate more applicable relevant research on microenvironment. We investigated effects altering glucose concentration source foetal bovine serum (FBS) growth two breast cancer cell lines (T47D MDA-MB-231) human bone marrow-derived mesenchymal (hBM-MSCs) determine successful conditions...
Abstract A questionnaire was developed to evaluate patients’ perspective on research aimed at improving functions and overcoming complications associated with spinal cord injury (SCI). The first three sections were based published validated assessment tools. final section assess participant perspectives for SCI. One thousand patients approached, of which 159 participated. Fifty-eight percent participants satisfied their ‘life as a whole’. Two factors could be generated that reflected the...
Introduction: For stem cell therapies to be adopted in mainstream health care, robust, reliable, and cost-effective storage transport processes must developed. Cryopreservation remains the best current platform for this purpose, freezing cells at high concentration may have many benefits, including savings on cost space, facilitating logistics, reducing cryoprotectant volume. Cells, such as mesenchymal (MSCs), are typically frozen 1 million per milliliter (mL), but aim of study is examine...