A5011513215- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Glycosylation and Glycoproteins Research
- Plant-Microbe Interactions and Immunity
- Nematode management and characterization studies
- Antimicrobial Peptides and Activities
- Legume Nitrogen Fixing Symbiosis
- Mycorrhizal Fungi and Plant Interactions
University of Georgia
2020-2025
Oak Ridge National Laboratory
2020
University of Tennessee at Knoxville
2020
Abstract Lipo-chitooligosaccharides (LCOs) are signaling molecules produced by rhizobial bacteria that trigger the nodulation process in legumes, and some fungi also establish symbiotic relationships with plants, notably arbuscular ecto mycorrhizal fungi. Here, we show many other produce LCOs. We tested 59 species representing most fungal phyla, found 53 LCOs can be detected functional assays and/or mass spectroscopy. LCO treatment affects spore germination, branching of hyphae, pseudohyphal...
Abstract DectiSomes are anti‐infective drug‐loaded liposomes targeted to pathogenic cells by pathogen receptors including the Dectins. We have previously used C‐type lectin (CTL) Dectin‐1, Dectin‐2, and DC‐SIGN target extracellular oligoglycans surrounding diverse fungi kill them. Dectin‐3 (also known as MCL, CLEC4D ) is a CTL receptor whose cognate ligands partly distinct from other CTLs. expressed purified truncated polypeptide (DEC3) comprised of its carbohydrate recognition domain stalk...
ABSTRACT The sialic acid Ig-like lectins Siglec-3 and Siglec-15 are pathogen receptors that bind acid-modified glycoproteins, best characterized in metastatic cancers. Because fungi produce sialoglycans sialo-glycoproteins, we wondered if Siglecs had the potential for targeted delivery of antifungal drugs. We purified extracellular V-region C2 ligand-binding domains stalk regions SIG3 SIG15. floated two polypeptides on surface liposomes loaded with amphotericin B (AmB) labeled rhodamine to...
Mucormycosis (a.k.a. zygomycosis) is an often-life-threatening disease caused by fungi from the ancient fungal division Mucoromycota. Globally, there are nearly a million people with disease. Rhizopus spp., and R. delemar (R. oryzae, arrhizus) in particular, responsible for most of diagnosed cases. Pulmonary, rhino-orbito-cerebral, invasive mucormycosis effectively treated amphotericin B (AmB) particularly liposomal formulations (e.g., AmBisome®). However, even after antifungal therapy,...
DectiSomes are anti-infective drug-loaded liposomes targeted to pathogenic cells by pathogen receptors including the Dectins. We have previously used C-type lectin (CTL) Dectin-1, Dectin-2, and DC-SIGN target extracellular oligoglycans surrounding diverse fungi kill them. Dectin-3 (a.k.a. MCL, CLEC4D ) is a CTL receptor whose known cognate ligands partly distinct from other CTLs. expressed purified truncated polypeptide (DEC3) comprised of its carbohydrate recognition domain stalk region....