Mg/N doped-carbon quantum dots (CQDs) with dual drug targeting and cell imaging properties was synthesized. doped-CQDs synthesized by a hydrothermal method. Operating pyrolysis parameters such as temperature, time, pH were optimized to achieve CQDs high yield (QY). This CQD applied in cellular imaging. For the first active of doped performed using folic acid hyaluronic (CQD-FA-HA). Then, epirubicin (EPI) loaded on this nanocarrier final complex (CQD-FA-HA-EPI). Cytotoxicity analysis, uptake,...

The aim of this study was to develop a stable polyethyleneimine/gold nanorod composite conjugated with carbon quantum dot (CQD) and hyaluronic acid (HA) complex (CQD-HA-PEI@GNRs) for applications in chemotherapy photothermal therapy. GNRs were synthesized using seed-mediated growth method, the amount seed solution optimized obtain an optimal aspect ratio strong peak near-infrared (NIR) region. surface then modified polyethylene imine (PEI). In parallel, CQDs through hydrothermal method...

Abstract Background Ceftriaxone is one of the most common types antibiotics used to treat deadly bacterial infections. One way alleviate side effects medication reduce drug consumption by changing ordinary forms into nanostructured forms. In this study, a lipid carrier (NLC) containing hydrophilic ceftriaxone sodium developed, and its effect on eliminating gram-negative bacteria Escherichia coli death investigated. Methods Double emulsion solvent evaporation method applied prepare NLC....

In this study, the potential of melatonin hormone loaded in nanostructured lipid carriers (Mel-NLCs) vitro fertilization (IVF) environment is investigated by measuring oocyte maturation, two-pre-nucleus embryo development, two-cell stage and blastocyst production on oocytes mice. Mel-NLCs are prepared using hot homogenization-ultrasonication method. A response surface method utilized to determine best independent variables obtain nanoparticles with a small particle size high entrapment...

In this study, a hybrid molecular dynamics--grand canonical Monte Carlo simulation is carried out to investigate the storage capacity of methane in new nanostructure adsorbent called pillared graphene. This composed graphene sheets parallel with vertical carbon nanotubes (CNTs), which act as their holders. The adsorption ability structure compared evaluate its potential for storage. results show that specific volume, applying increases number adsorbed up 22% comparison sheets. Given...

In this study, molecular dynamics simulation is used to investigate the adsorption of an anticancer drug, doxorubicin, on bundles functionalized single-walled carbon nanotubes (SWNTs) in aqueous solution. Carboxylic group has been selected as functional group. Molecular (MD) simulations are performed for both separated systems containing a SWNT bundle and nanotube bundle, results compared with existing experimental data. MD show that doxorubicin can be adsorbed CNTs using different methods...

Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator which orally used for treatment of osteoporosis and prevention breast cancer. The drug has low aqueous solubility bioavailability. aim the present study to formulate characterize oil-in-water microemulsion systems oral delivery RLX. To enhance solubility, based on sesame oil was prepared. Sesame Tween 80 were selected as solvent surfactant, respectively. In first second formulations, Edible glycerin Span applied...

Abstract In this study, the efficacy of sublingual squalene in decreasing mortality rate among patients with COVID-19 was investigated. Squalene extracted from pumpkin seed oil a novel method. Then, microemulsion form prepared for usage. clinical 850 admitted patients, 602 eligible were divided two groups control (N = 301) and cases between Nov 2021 Jan 2022. Groups statistically same terms age, sex, BMI, lymphocyte count on 1 st admission day, hypertension, chronic kidney disease,...

N-doped carbon quantum dot (CQD) nanoparticle was prepared as a novel nanocarrier with excellent solubility, stability, and high yield to overcome Indocyanine Green (ICG) obstacle in photodynamic therapy (PDT) simultaneous cell imaging property. Cell culture study In vivo assessments on the C57BL/6 mice containing melanoma cancer cells performed. Results showed that CQD size after ICG loading slightly enhanced from 24.55 nm 42.67 nm. Detection of reactive oxygen species (ROS) test...

Encapsulation of essential oils (EOs) is an important strategy that can be applied to intensify the stability and efficiency these compounds in integrated pest management. The present study aimed investigate sub-lethal activity polymer-based EOs nanoparticles against red flour beetle, Tribolium castaneum adults as critical stored products. Chitosan (CSNPs) containing garlic cinnamon (GEO CEO) prepared using ionic cross-link technique. Stability nano-formulations evaluated over temperature...

CL-20, a high-energy material with cage-like structure, is considered the most powerful explosive today. It usually prepared via nitration concentrated nitric and sulfuric acid, but this technique pollutes environment. In article, CL-20 was synthesized by of 2,6,8,12-tetraacetyl 2,4,6,8,10,12-hexaazatetracyclo[5,5,0,03,11,05,9]dodecane (TAIW) using clean nitrating agent, heteropolyacids. Using new agent caused elimination acid during reaction. This an environmentally friendly technique.

This study investigates the effect of nanostructure squalene in form microemulsion on COVID-19 patients. In this blinded clinical trial, a comparison was made between efficacy treatment and controls. A total 30 patients admitted to emergency department, infection ward equally allocated case (n = 15) control groups according their age underlying diseases. The baseline characteristics subjects, including age, gender, time onset, condition, white blood cells count, lymphocyte count were similar...

Abstract This study investigates the ability of functionalized multiwalled carbon nanotubes (MWCNTs) for enantio‐separation metoprolol chiral forms. 2Hydroxypropyl‐ β ‐cyclodextrin (2HP‐ ‐CD) was applied as a selector to functionalize (CNTs). The modified CNT samples were characterized using scanning electron microscopy and Fourier transform infrared spectroscopy. results analyses showed that CNTs successfully cross‐linked with 2HP‐ ‐CD. To evaluate property products, separation forms on...