A5061412841- Histone Deacetylase Inhibitors Research
- PARP inhibition in cancer therapy
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Advanced Breast Cancer Therapies
- Cancer, Lipids, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- FOXO transcription factor regulation
- Apelin-related biomedical research
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Lipid metabolism and disorders
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- Food Security and Health in Diverse Populations
- Antioxidant Activity and Oxidative Stress
- Child Nutrition and Water Access
- Curcumin's Biomedical Applications
- Colorectal Cancer Treatments and Studies
- Global Maternal and Child Health
Olivia Newton-John Cancer Wellness & Research Centre
2021-2022
La Trobe University
2021-2022
Ministry of Health and Family Welfare
2019
Abstract The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors this that they primarily induce cytostatic effects cancer cells. Nevertheless, these drugs do expression proapoptotic factors, suggesting may prime cells to undergo apoptosis. As histone deacetylase (HDACis) multiple proteins, we examined whether could synergize with ERK/MAPK trigger cell Combined MEK/ERK and HDAC inhibition synergistically induced...
In order to reduce child mortality, recommendations for diarrhea management practices have been widely promoted by various methods, including mass media. This study examined whether mother's exposure media was associated with child's diarrhea, and the practiced their mothers. Data on 7,068 women, whose youngest under five years old, were extracted from Bangladesh Demographic Health Survey, 2011, together information child. The outcome variables an episode of in two weeks prior survey...
Natural compounds of plant origin are being used in cancer research since several decades. More than treatment, they hold promise prevention. Besides cancer, also other health disorders. Interest natural mediated treatment is increasing due to their low toxicity, wide variety benefits and abundance. They can be easily obtained from nature taken diet without doctor consulting based upon availability. As do not result significant problems, a little change dietary habits give us benefit against...
<p>Supplementary figure 2 shows the effect of trametinib plus panobinostat on colony formation in HCT 116 cells</p>
<p>Supplementary figure 3 shows combining trametinib with different classes of HDAC inhibitors in COLO 201 cells</p>
<div>Abstract<p>The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors this that they primarily induce cytostatic effects cancer cells. Nevertheless, these drugs do expression proapoptotic factors, suggesting may prime cells to undergo apoptosis. As histone deacetylase (HDACis) multiple proteins, we examined whether could synergize with ERK/MAPK trigger cell Combined MEK/ERK and HDAC inhibition...
<p>Supplementary Figure 1 shows the synergistic effect of trametinib plus panobinostat in CRC cell lines and PDTO's</p>
<p>Supplementary figure 2 shows the effect of trametinib plus panobinostat on colony formation in HCT 116 cells</p>
<p>Supplementary figure 3 shows combining trametinib with different classes of HDAC inhibitors in COLO 201 cells</p>
<div>Abstract<p>The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyperactivated in most colorectal cancers. A current limitation of inhibitors this that they primarily induce cytostatic effects cancer cells. Nevertheless, these drugs do expression proapoptotic factors, suggesting may prime cells to undergo apoptosis. As histone deacetylase (HDACis) multiple proteins, we examined whether could synergize with ERK/MAPK trigger cell Combined MEK/ERK and HDAC inhibition...
<p>Supplementary figure 4 shows phosphorylated ERK staining in an adenoma from a ACDX2 mouse</p>
<p>Supplementary figure 5 shows mouse weight during treatment in two of the studies</p>
<p>Supplementary Figure 1 shows the synergistic effect of trametinib plus panobinostat in CRC cell lines and PDTO's</p>
<p>Supplementary figure 4 shows phosphorylated ERK staining in an adenoma from a ACDX2 mouse</p>
<p>Supplementary figure 5 shows mouse weight during treatment in two of the studies</p>
Abstract The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyper-activated in most colorectal cancers (CRCs). A current limitation of inhibitors this that they primarily induce cytostatic effects CRC cells. Nevertheless, these drugs do expression pro-apoptotic factors, suggesting may prime cells to undergo apoptosis. As histone deacetylase (HDACi) multiple proteins, we examined whether could synergize with ERK/MAPK trigger cell Combined MEK/ERK and HDAC inhibition synergistically induced...
Abstract The EGFR/RAS/MEK/ERK signalling pathway (ERK/MAPK) is hyper-activated in most colorectal cancers (CRCs). A current limitation of inhibitors this that they primarily induce cytostatic effects CRC cells. Nevertheless, these drugs do expression pro-apoptotic factors, suggesting may prime cells to undergo apoptosis. As histone deacetylase (HDACi) multiple proteins, we examined whether could synergize with ERK/MAPK trigger cell Combined MEK/ERK and HDAC inhibition synergistically induced...