A5079492639- Cardiac Fibrosis and Remodeling
- Drug-Induced Hepatotoxicity and Protection
- Ginger and Zingiberaceae research
- Cardiac electrophysiology and arrhythmias
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced organ toxicity mitigation
- Diet, Metabolism, and Disease
- Paraoxonase enzyme and polymorphisms
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Insect and Pesticide Research
- Organic Light-Emitting Diodes Research
- Adenosine and Purinergic Signaling
- Chemotherapy-induced cardiotoxicity and mitigation
- Bioactive Compounds and Antitumor Agents
- Advanced Glycation End Products research
- Neurotransmitter Receptor Influence on Behavior
- Genomics, phytochemicals, and oxidative stress
- Pregnancy and Medication Impact
- Drug Transport and Resistance Mechanisms
- Cardiovascular Issues in Pregnancy
- Electrospun Nanofibers in Biomedical Applications
- Pancreatitis Pathology and Treatment
- Receptor Mechanisms and Signaling
- NF-κB Signaling Pathways
King Saud University
2019-2025
Ethanol consumption is one of the common causative agents implicated in gastric ulcer development. Oxidative stress plays a major role induction and development ulceration. NADPH oxidases (NOXs) Nuclear factor erythroid 2-related 2 (Nrf2) are key players ethanol-induced ulcers. High-mobility group box 1 (HMGB1), ubiquitous nuclear protein, mediates various inflammation functions. However, HMGB1 not yet elucidated. Raspberry Ketone (RK) natural phenolic compound with antioxidant...
Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-induced nephrotoxicity characterized by the interplay of oxidative stress, inflammation, and apoptosis. Toll-4 receptors (TLR4) NLPR3 inflammasome are pattern-recognition responsible for activating inflammatory responses assigned to play significant role gasdermin (GSDMD) in acute kidney injuries. N-acetylcysteine (NAC) chlorogenic acid (CGA) have documented nephroprotective effects suppressing pathways....
Tamoxifen (TAM) is extensively used to manage estrogen receptor-positive breast cancer. Despite its effectiveness, administration can negatively impact various organs, including the liver. This research focused on effects of TAM pyroptotic pathway in liver and evaluated potential cardamom extract (CRDE) lessen hepatic damage female rats. Rats received 45 mg/kg injections for 10 days, while groups treated with CRDE 12 ml/kg 20 commencing days before administration. exposure resulted apparent...
Aim. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and if untreated, it may propagate into end-stage disease. The classical arm renin-angiotensin system (RAS) has a fundamental role in triggering oxidative stress inflammation, which play potential roles pathogenesis NAFLD. However, nonclassical alternative axis RAS, angiotensin- (Ang-) converting enzyme 2 (ACE2)/Ang (1-7)/Mas receptor, opposes actions arm, mitigates dysfunction, improves lipid...
Pathological cardiac remodeling is associated with cardiovascular disease and can lead to heart failure. Nuclear factor-kappa B (NF-κB) upregulated in the hypertrophic heart. Moreover, expression of G-protein-coupled receptor kinase 2 (GRK2) increased linked progression The inhibitory effects paroxetine on GRK2 have been established. However, its protective effect IκBα/NFκB signaling has not elucidated. This study investigated cardioprotective an animal model hypertrophy (CH), focusing...
Background: Although doxorubicin (DXR) is one of the most used anticancer drugs, it can cause life-threatening renal damage. There has been no effective treatment for DXR-induced damage until now. Aim: This work aims at examining potential impact nano-resveratrol (N-Resv), native resveratrol (Resv), and their combination with carvedilol (Card) against toxicity in rats to investigate mechanisms through which these antioxidants act ameliorate DXR nephrotoxicity. Method: was administered (2...
Amiodarone (AMD), an antiarrhythmic drug, is used cautiously due to its lung toxicity that characterized by alveolar inflammation followed fatal fibrosis. AMD induces via increasing the macrophages and disturbing balance of T-helper-1 (Th1) Th2 cells cytokines. In this study, role mitogen-activated protein kinases (MAPKs)/activator protein-1 (AP-1) pathway in AMD-induced was evaluated. Also, anti-inflammatory antifibrotic effects losartan and/or vitamin D were investigated following 7, 14,...
Post-acute myocardial infarction (AMI) fibrosis is a pathophysiologic process characterised by activation of the profibrotic mediator, transforming growth factor-β (TGF-β). AMI associated with substantial increase in levels extracellular adenosine triphosphate (eATP), which acts on purinergic P2X7-receptor (P2X7-R) and triggers an inflammatory response that contributes to fibrotic remodelling. P2X7-R has been implicated several cardiovascular diseases; however, its role regulation cardiac...
Adansonia digitata L. is an African tree commonly called baobab. This effectively used in traditional medicine to treat cardiovascular disorders. Hyperlipidemia a well-known risk factor associated with the increased incidence of mortality worldwide. study aimed demonstrate mechanism baobab polyphenols activities hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and pancreatic lipase as lipid metabolic enzymes. Molecular docking incentive for drug design showed that all bound proteins...
Infected burned skin is a life-threatening condition, which may lead to sepsis. The aims of this work are formulate biofilm composed silver sulfadiazine (SSD), chitosan (CS), and sodium alginate (SA), evaluate its wound-healing effectiveness. A full factorial design was used different matrix formulations. prepared tested for physicochemical, in vitro release. optimized formulation 0.833% CS 0.75% SA. release SSD almost reached 100% after 6 h. mechanical properties the formula were...
Background: G protein coupled receptor kinase 5 (GRK5) exerts a negative regulatory function for β-adrenoceptor activation, which plays an important role in cardiac and contractility. Importantly, GRK5 expression has been found to play pathological disease development. However, the endogenous gene change its level animal model of hypertrophy (CH) is not well elucidated yet. The current study aimed investigate myocytes peripherally circulated lymphocytes using isoproterenol (ISO) induced...