A5084525747- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Proteoglycans and glycosaminoglycans research
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Valve Diseases and Treatments
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- RNA regulation and disease
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Prenatal Substance Exposure Effects
- Pulmonary Hypertension Research and Treatments
Emory University
2021-2024
Atlanta VA Health Care System
2021-2024
Florida State University
2020
Abstract Temporal lobe epilepsy (TLE) is the most common type of drug-resistant in adults, with an unknown etiology. A hallmark TLE characteristic loss layer 3 neurons medial entorhinal area (MEA) that underlies seizure development. One approach to intervention preventing these through better understanding underlying pathophysiological mechanisms. Here, we show both and glia together give rise pathology mitigated by amino acid D-serine whose levels are potentially diminished under epileptic...
Vascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through ability to transition between different phenotypes. Our group discovered that the deficiency of mitochondrial protein Poldip2 induces VSMC differentiation both vivo and vitro. Further comprehensive biochemical investigations revealed Poldip2's specific interaction with ATPase caseinolytic protease chaperone subunit X (CLPX), which is regulatory...
Excessive alcohol use increases the risk of developing respiratory infections partially due to impaired alveolar macrophage (AM) phagocytic capacity. Previously, we showed that chronic ethanol (EtOH) exposure led mitochondrial derangements and diminished oxidative phosphorylation in AM. Since is needed meet energy demands phagocytosis, EtOH mediated decreases likely contribute AM phagocytosis. Treatment with peroxisome proliferator-activated receptor gamma (PPARγ) ligand, pioglitazone (PIO),...
RGS14 is a complex multifunctional scaffolding protein that highly enriched within pyramidal cells (PCs) of hippocampal area CA2. In these neurons, suppresses glutamate-induced calcium influx and related G ERK signaling in dendritic spines to restrain postsynaptic plasticity. Previous findings show that, unlike PCs areas CA1 CA3, CA2 are resistant number neurological insults, including degeneration caused by temporal lobe epilepsy (TLE). While protective against peripheral injury, similar...
RGS14 is a complex multifunctional scaffolding protein that highly enriched within pyramidal cells (PCs) of hippocampal area CA2. There, suppresses glutamate-induced calcium influx and related G ERK signaling in dendritic spines to restrain postsynaptic plasticity. Previous findings show that, unlike PCs areas CA1 CA3, CA2 are resistant number neurological insults, including degeneration caused by temporal lobe epilepsy (TLE). While protective against peripheral injury, similar roles for...
People with alcohol use disorder (AUD) have an increased risk of developing pneumonia and pulmonary diseases. Alveolar macrophages (AMs) are immune cells the lower respiratory tract that necessary for clearance pathogens. However, causes AM oxidative stress, mitochondrial damage dysfunction, diminished phagocytic capacity, leading to lung injury suppression.
Pulmonary hypertension (PH) comprises a diverse group of disorders that share common pathway pulmonary vascular remodeling leading to right ventricular failure. Development anti-remodeling strategies is an emerging frontier in PH therapeutics requires greater understanding the interactions between wall cells and their extracellular matrices. The ubiquitous matrix glycan, hyaluronan (HA), markedly elevated lungs from patients experimental models with PH. Herein, we identified HA synthase-2...
Alveolar macrophages (AMs) are the first line of cellular defense in lower airway against pathogens. However, chronic and excessive alcohol use impairs ability AMs to phagocytize clear pathogens from alveolar space, part through dysregulated fuel metabolism bioenergetics. Our prior work has shown that ethanol (EtOH) consumption mitochondrial bioenergetics increases lactate levels AMs. Further, we recently demonstrated EtOH glutamine dependency glutamine-dependent maximal respiration while...