A5062825929- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Antibiotic Resistance in Bacteria
- Cyclization and Aryne Chemistry
- Catalytic Alkyne Reactions
- Organoboron and organosilicon chemistry
- Synthesis of Organic Compounds
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthesis and Reactions of Organic Compounds
- Chemical Reactions and Mechanisms
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Burkholderia infections and melioidosis
- Antibiotics Pharmacokinetics and Efficacy
- Cyclopropane Reaction Mechanisms
- Neutropenia and Cancer Infections
Redx Pharma (United Kingdom)
2016
University of Sheffield
2010-2013
AstraZeneca (United Kingdom)
2012
The synthesis of a range novel ynone trifluoroborates has been achieved, in two-pot process from propargylic alcohols. These alkynes have subsequently used the formation pyrazole trifluoroborate salts via cyclization with hydrazines. products are generated high levels regiocontrol and excellent yields represent versatile synthetic intermediates.
Simple as ABC: Alkynyl borane cycloadditions can be substrate-directed to assemble aromatic difluoroboranes within an extremely mild and efficient reaction manifold compared that of traditional methods (see scheme). The boranes are readily transformed into a range useful products. Detailed facts importance specialist readers published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: publisher is...
A new approach to benzyne precursors has been developed that involves the [4+2] cycloaddition of trimethylsilyl alkynylboronates with 2-pyrones, followed by oxidation and trifluoromethylsulfonylation boronate moiety.
Arenborane leicht gemacht: Cycloadditionen mit Alkinylboranen zur Bildung aromatischer Difluorborane wurden entwickelt, die unter sehr viel milderen und effizienteren Reaktionsbedingungen als konventionellen Methoden durchgeführt werden können (siehe Schema). Die aromatischen Borane lassen sich in eine Reihe nützlicher Produkte überführen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or...
The [4+2] cycloaddition of 2-pyrones with substituted alkynylboronates has been studied. In general, the highest yielding cycloadditions were obtained in reactions that employed a trimethylsilyl-substituted alkynylboronate. regioselectivities using corresponding phenyl-substituted alkyne, which provided single regioisomer irrespective 2-pyrone used. Mechanistic studies suggest high regioselectivity observed is due to stabilization zwitterionic transition state.
Antimicrobial resistance is a global issue, and the investigation of alternative therapies that are not traditional antibiotics warranted. Novel bacterial type II topoisomerase inhibitors (NBTIs) have recently emerged as novel class with reduced potential for cross-resistance to fluoroquinolones due their mechanism action. This study investigated in vitro activity series cyclohexyl–oxazolidinone against strains Francisella tularensis Burkholderia pseudomallei. Broth microdilution, time-kill,...
Abstract Coupling of novel ynone trifluoroborates like (III) with hydrazines provides a new, efficient, and regioselective approach to pyrazole as precursors diverse derivatives.
Abstract The cycloaddition of 2‐pyrones with alkynylboronate (II) followed by C‐B bond oxidation and a subsequent triflation gives rise to mixtures regioisomers (VI) (VII), which are shown be useful benzyne precursors.