Background/Objectives: Hair loss affects self-esteem, confidence, and psychological well-being. Exosomes, as molecular carriers of growth factors active compounds, offer a promising treatment. This study evaluates the efficacy an exosome formulation containing extracts from two known hair-regenerating plants, Ecklonia cava Thuja orientalis (ECPE), for male pattern alopecia. Methods: A randomized controlled trial included 20 participants with Norwood grade 2–3 androgenetic alopecia who were...

Objective: To examine the wound healing properties of eicosane, pentadecane and palmitic acid by evaluating in term anti-microbial, anti-inflammatory, proliferation, migration collagen synthesis. Methods: Anti-microbial activities Staphylococcus aureus, Bacillus subtilis, Escherichia coli Pseudomonas aeruginosa were evaluated carrying out disk diffusion agar well methods. Growth rate tested bacteria was also for 8 h conjunction with sample drugs. Besides, U937 cell lines used as model study...

The interplay of physical, social, and economic factors during the pandemic adversely affected mental health healthy people exacerbated pre-existing disorders. This study aimed to determine impact COVID-19 on general population in Malaysia. A cross-sectional involving 1246 participants was conducted. validated questionnaire consisting level knowledge practice precautionary behaviors, Depression, Anxiety, Stress Scales (DASS), World Health Organization Quality Life—Brief Version (WHOQOL-BREF)...

Ceramides plays a crucial role in maintaining skin barrier function. Although foregoing evidence supported beneficial effects of topical ceramides for restoration the barrier, studies on oral are extremely scarce, with most published data collected from vivo and vitro models. Thus, this study aimed to evaluate efficacy rice (RC) supplementation improve function as depigmenting agent through comprehensive clinical assessments. This investigated orally administered RC 50 voluntary...

Asian countries, including Indonesia, have experienced a significant shift in their diet with increased fast food consumption spurred by rapid economic expansion, urbanisation and social changes. Increasing mortality morbidity following obesity noncommunicable diseases been linked to an imbalanced nutrient intake. This study assessed the pattern of overweight, intake Indonesian adults. Three hundred eighty-five participants were conveniently recruited; completed questionnaire encompassing...

Gene-diet interaction studies have reported that individual variations in phenotypic traits may be due to diet. Our study aimed evaluate (i) the association of ADRB2 rs1042713 with obesity and obesity-related metabolic parameters (ii) effect dietary nutrients on these associations Malaysian adults. genotyping, dietary, physical activity, anthropometric, biochemical data were collected from 79 obese 99 nonobese individuals. Logistic regression revealed no between (p=0.725). However, carriers...

Refractory dermal melasma is resistant to conventional treatment. Platelet rich plasma (PRP) may help reduce the pigmentation of melasma. We present a case report on clinical outcome 2 patients with melasma, given PRP, as an adjunct therapy. PRP was administered at monthly interval for sessions in combination Q-switched Nd Yag laser treatment and topical alpha arbutin application. A modified area severity index (MASI) evaluated by two dermatologists who were blinded. At follow up 3rd months,...

Abstract This study aims to define the prevalence and molecular basis of G6PD deficiency in Negrito tribe Malaysian Orang Asli. Four hundred eighty seven consenting volunteers were screened for through use a fluorescent spot test. DNA from deficient individuals underwent PCR‐RFLP analysis using thirteen recognized mutations. In instances when mutation could not be identified by PCR‐RFLP, entire coding region gene was subjected sequencing. total, 9% (44/486) sample found G6PD‐deficient....

Background: Skin regeneration is critical in diabetic wound healing. Anti-inflammatory activity of 2-Pentadecanone (2-P), identified from Marantodes pumilum was reported our previous studies. Objective: This study aimed at evaluating 2-P healing and anti-bacterial activities. Materials Methods: Fifteen streptozotocin-induced type 2 Sprague Dawley rats were divided into negative (N), positive (P), treatment (2-P) groups. aqueous cream applied daily to 5 mm excision wounds up day 15. Wound...

Individual variations of obesity-related traits can be a consequence dietary influence on gene variants.This cross-sectional study aimed to evaluate (i) the effect FTO rs9930506 obesity and related parameters (ii) diet above association in Malaysian adults. In total, 79 obese 99 nonobese adults were recruited.In comparison with Chinese Malays, Indians had significantly higher waist circumference (P ≤ 0.001 P = 0.016), waist-hip ratio < 0.001), body fat percentage 0.042), fasting insulin...

Malaysia has been experiencing smoke-haze episodes almost annually for the past few decades. PM2.5 is main component in haze and causes harmful impacts on health due to its small aerodynamic size. This study aimed explore implications of exposure dietary intake working individuals. Two phased 13-weeks follow-up was conducted involving 440 participants, consisting two cohorts outdoor indoor workers. Ambient concentrations were monitored using DustTrakTM DRX Aerosol Monitor. Data Simplified...

Monotherapy for triple-negative breast cancer (TNBC) is often ineffective. This study aimed to investigate the effect of calcitriol and talazoparib combination on cell proliferation, migration, apoptosis cycle in TNBC lines. Monotherapies their were studied (i.) antiproliferative (using real-time analyzer assay), (ii.) migration (CIM-Plate (iii.) analysis (flow cytometry) MDA-MB-468 BT-20 The optimal concentration was 91.6 10 µM, respectively, MDA-MB-468, it 1 mM µM. Combined treatment...