A5022095260- Liver Disease Diagnosis and Treatment
- Hydrology and Watershed Management Studies
- Toxic Organic Pollutants Impact
- Liver Disease and Transplantation
- Water Systems and Optimization
- Hepatitis C virus research
- Urban Stormwater Management Solutions
- Hepatitis B Virus Studies
- Groundwater flow and contamination studies
- Drug-Induced Hepatotoxicity and Protection
- Pesticide and Herbicide Environmental Studies
- Pharmacogenetics and Drug Metabolism
- Soil erosion and sediment transport
- Soil and Water Nutrient Dynamics
- Water Quality and Pollution Assessment
- Water resources management and optimization
- Environmental Toxicology and Ecotoxicology
- Soil and Unsaturated Flow
- French Urban and Social Studies
- Water Treatment and Disinfection
- Drug Transport and Resistance Mechanisms
- Soil Geostatistics and Mapping
- Hydraulic flow and structures
- Marine and coastal ecosystems
- Irrigation Practices and Water Management
Université de Montréal
2000-2022
Centre Hospitalier de l’Université de Montréal
2001-2022
Institut National de la Recherche Scientifique
2008-2020
Hôpital Saint-Luc
2002-2015
International Atomic Energy Agency
2012
International University of Monaco
1990-2010
Hydro-Québec
2008-2010
École de Technologie Supérieure
2010
International Atomic Energy Agency
1977-2009
Université Laval
1978-2009
The prognosis of decompensated cirrhosis resulting from chronic hepatitis B is poor, and the benefits treatment with interferon are outweighed by serious side effects risk fatal exacerbation disease activity. Lamivudine rapidly reduces virus (HBV)-DNA in serum to undetectable levels. We have treated 35 patients lamivudine 100 mg or 150 orally once daily. Pretreatment, all were positive for HBV-DNA serum. Ten had Child-Pugh class 25 C liver disease. Seven underwent transplantation within 6...
Three–hundred and twenty–four patients were enrolled in an open–label, multicenter, international study which pre– post–liver transplantation (LT) with recurrent chronic hepatitis B (CHB) evidence of lamivudine–resistant HBV treated adefovir dipivoxil 10 mg once daily. In the post–LT cohorts, 128 196 for a median duration 18.7 56.1 weeks, respectively. who received 48 weeks treatment, 81% pre–LT 34% cohort achieved undetectable serum virus (HBV) DNA (Roche Amplicor Monitor TM polymerase...
The objective of this study was to assess the prognostic validity Child-Turcotte classification with regard short-term (1-year) survival. classification, as modified by Pugh et al., recorded on admission in 177 cirrhotic patients. variables that comprise modification are ascites, encephalopathy, serum albumin, bilirubin and prothrombin time. Using multiple logistic regression, we evaluated contribution different models likelihood survival, defining ways use score. score categorized three...
Mutations within the hepatitis B virus (HBV) polymerase gene conferring drug-resistance are selected during prolonged lamivudine (3TC) or adefovir dipivoxil (ADV) treatment. Because there is no other approved drug against HBV, treatments with 3TC ADV used either sequentially in addition, depending on treatment response failure. Considering use of de novo add-on 3TC+ADV bitherapy, we investigated possibility emergence an HBV strain harboring mutations resistance to both (rtL180M+M204V) and...
A distributed hydrological model compatible with remote sensing and GIS has been developed over the past years. Run on microcomputers a user-friendly interface, HYDROTEL can be applied to wide range of watersheds due account for available data, as choice options is offered simulation various processes. Algorithms derived much possible from physical processes, together more conceptual or empirical algorithms have selected. Also, natural units chosen simulations: small subwatersheds vertical...
Wait-listed (n = 226) or post-liver transplantation 241) chronic hepatitis B (CHB) patients with lamivudine-resistant virus (HBV) were treated adefovir dipivoxil for a median of 39 and 99 weeks, respectively. Among wait-listed patients, serum HBV DNA levels became undetectable (<1,000 copies/mL) in 59% 65% at weeks 48 96, After alanine aminotransferase (ALT), albumin, bilirubin, prothrombin time normalized 77%, 76%, 60%, 84% posttransplantation 40% ALT, 51%, 81%, 56% who underwent on-study...
We conducted a prospective, randomized single-blind trial of propranolol for the prevention recurrent variceal bleeding. Seventy-nine patients shown to have hemorrhage at endoscopy were included in study within 72 hr following diagnosis. Fifty-seven had alcoholic cirrhosis, 10 cryptogenic 6 posthepatitic 4 biliary 1 portal vein thrombosis without cirrhosis and idiopathic hypertension. The severity liver disease inclusion was assessed according Pugh modification Child-Turcotte classification:...
Inflammatory immune cells can modulate activation of hepatic stellate (HSCs) and progression liver fibrosis. Type 3 inflammation characterized by production interleukin-17A (IL-17) IL-22 innate adaptive is implicated in many inflammatory conditions the gut be counteracted regulatory T (Tregs), but its contribution to fibrosis still poorly understood. Here, we evaluated type using clinical biopsies, vitro stimulation primary HSCs, vivo mouse models. We report dysregulated responses fibrotic...
Bacterial infection is a frequent and severe complication of cirrhosis. Cirrhotic patients admitted for gastrointestinal bleeding are at high risk such have been targeted in trials antibiotic prophylaxis. However, it has not shown that these higher than cirrhotic hospitalized other reasons. This prospective study was performed to assess the bacterial unselected evaluate possible factors this complication.One hundred-forty without clinical evidence time initial presentation were followed-up...
Municipal water infrastructure systems are in poor condition and deteriorating rapidly. A general diagnosis of the actual structural state these is needed, as tools to assess their rate deterioration. To make a diagnosis, one must collect analyze data on characteristics pipes breakage histories. Unfortunately, many municipalities have only been rigorously recording histories for decade, while ground much longer. modeling strategy, inspired by survival analysis using annual number pipe breaks...
The effects of alterations the hepatic blood flow, intrinsic clearance, and anatomy portal circulation on drug disposition were investigated in 53 cirrhotic patients with hypertension using indocyanine green (ICG) lidocaine as model drugs. ICG was studied by sampling from an artery one vein following i.v. injection, determination systemic clearances flow. Lidocaine oral administration peripheral disappearance curves, availability. shunted fraction intestinal flow (f) measured combined...
ABSTRACT The majority of acute hepatitis C virus (HCV) infections progress to chronicity and progressive liver damage. Alpha interferon (IFN-α) antiviral therapy achieves the highest rate success when IFN-α is administered early during phase, but underlying mechanisms are unknown. We used a panel major histocompatibility complex class I tetramers monitor phenotypic functional signatures HCV-specific T cells HCV infection with different outcomes IFN therapy. demonstrate that spontaneous...
The simultaneous measurement of wedged hepatic vein pressure (WHVP) and portal (PVP) was performed in 156 cirrhotic patients. In the 110 alcoholic patients (97 micronodular 13 macronodular cirrhosis), WHVP PVP were closely related (25.8 +/- 6.3 vs. 25.9 mm Hg; p = not statistically significant). difference between two parameters greater than 4 Hg only six 46 with nonalcoholic cirrhosis (41 1 cirrhosis; primary biliary significantly higher 6.2 21.7 6.8 less 0.001); 20 patients, exceeded by...