A5042318066- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Head and Neck Surgical Oncology
- Cardiovascular and exercise physiology
- Cardiac tumors and thrombi
- Myasthenia Gravis and Thymoma
- Pericarditis and Cardiac Tamponade
- Neonatal Respiratory Health Research
- Helminth infection and control
- Atherosclerosis and Cardiovascular Diseases
- CNS Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aluminum toxicity and tolerance in plants and animals
- Parasites and Host Interactions
- Ear Surgery and Otitis Media
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Meningioma and schwannoma management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pituitary Gland Disorders and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
Hospital Prof. Dr. Fernando Fonseca
2018-2024
Universitat de Barcelona
2020-2024
Hospital Clínic de Barcelona
2020-2024
Centro Hospitalar de Lisboa Ocidental
2024
Universidade Nova de Lisboa
2024
Nova Medical (United States)
2021-2023
Response Biomedical (Canada)
2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020
University of Lisbon
2016
Abstract Background Microscopic polyangiitis (MPA) and granulomatosis with (GPA) are the two major antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). Objectives To characterize a homogenous AAV cohort to assess impact of clinicopathological profiles ANCA serotypes on clinical presentation prognosis. Clinical differences in GPA patients according serotype diagnostic yield for biopsies different territories were also investigated. Results This retrospective study...
Giant cell arteritis (GCA) may manifest with aggressive intracranial stenosis resistant to medical therapy, and patients develop refractory neurologic deficits cerebral infarcts, making GCA a life-threatening condition. We report the case of 68-year-old woman recently diagnosed GCA, medicated prednisolone 60 mg daily. Two weeks later, patient was admitted our Stroke Unit after sudden episode global aphasia. Magnetic resonance angiography showed two recent ischaemic lesions, besides an...
Background Autoimmune inner ear disease (AIED) represents less than 1% of all cases sensorineural hearing loss (SNHL) but its frequency may be underestimated due to lack specific clinical and laboratory criteria. AIED can associated with a systemic autoimmune (SAID) in 15%-30% the cases. The objective present study was characterize prognostic factors cohort patients AIED. Materials methods authors conducted retrospective descriptive analysis referred from otorhinolaryngology department...
Baroreflex function is an independent marker of prognosis in heart failure (HF). However, little known about its relation to response cardiac resynchronization therapy (CRT). The aim this study assess arterial baroreflex HF patients who are candidates for CRT.The population consisted 25 with indication CRT, aged 65±10 years, NYHA functional class ≥III 52%, QRS width 159±15 ms, left ventricular ejection fraction (LVEF) 29±5%, end-systolic volume (LVESV) 150±48 ml, B-type natriuretic peptide...
Because of a similar organ involvement and histopathological features, IgG4-related disease (IgG4-RD) may mimic some forms granulomatosis with polyangiitis (GPA). However, several cases clear coexistence or overlap both diseases have been reported. We describe case 47-year-old man presenting renal mass nasal crusting showing features IgG4-RD in territories. Cytoplasmic/proteinase 3 (PR3) antineutrophil cytoplasmic antibodies (ANCA) were positive the patient subsequently developed kidney...
<h3>Background:</h3> Giant Cell Arteritis (GCA) is the most frequent vasculitis in patients older than 50 years-old. Increasing use of imaging tools for diagnosis GCA led to recognition extracranial Large-Vessel (LV-GCA) involvement a significant proportion patients. Around two-thirds with are reported have LV-GCA [1,2]. phenotypes may vary according age at diagnosis, cranial manifestations being more prominent and younger 65 years-old [3]. Atherosclerosis highly prevalent among an advanced...
Introduction Wheezing is common in preschool-aged children, affecting about half of all children within their first six years life. Children who have recurrent wheezing experience disease-related morbidity, including increased emergency visits and hospitalizations. Early-life lower respiratory tract viral infections are linked to eventual asthma onset. Identifying high-risk crucial, with the frequency severity episodes being good predictors long-term outcomes. Aim To identify severe...
<h3>Objective</h3> Glucocorticoids (GC) have been used for the treatment of lupus over 60 years. Current recommendations suggest using lowest dose shortest period to reduce adverse effects (AE). Nevertheless, little is known about patients´ perspective on steroid use. Our study aims at understanding patient's perception effectiveness and safety therapy. <h3>Methods</h3> A survey was conducted in SLE patients (2019 EULAR/ACR classification criteria). Results were analyzed Stata 14.0....
Human fascioliasis is a trematode parasitic disease with worldwide distribution. Natural reservoirs include several ruminants, mainly sheep, goats and cattle.1 Humans are accidental hosts acquire infection by ingestion of metacercaria present in aquatic plants.1,2 This food-borne zoonosis has claimed little attention clinical practice. However, increasing reports the travel medicine recognition endemic areas many countries have contributed to importance Fasciola infection.3 Despite that, it...
A 65-year-old man presented with a 2-year history of severe bilateral proptosis, palpable lymphadenopathy and moderate hepatosplenomegaly. blood test was positive for hepatitis C infection. CT showed palpebral infiltrative lesions regional progression through the temporal masticatory spaces to pharynx hypopharynx causing almost complete airway obstruction. biopsy consistent low-grade Bcl-2+ extra-nodal MALT non-Hodgkin B-cell lymphoma. The patient received six cycles rituximab-based...
Introdução: A pericardite aguda é uma síndrome frequente caracterizada pela inflamação do pericárdio e usualmente atribuído a etiologia viral/idiopática. Apesar dos avanços no tratamento, existe informação limitada em relação prognóstico. O objetivo nosso trabalho foi identificar prevalência de com especifica avaliar marcadores clínicos prognóstico.
 Material Métodos: Estudo retrospetivo doentes hospitalizados por entre 2012-2016. população quanto etiologia, apresentação clínica,...
Background: Lung involvement is frequent in ANCA-associated vasculitis (AAV). Classical lung manifestations consist of capillaritis with haemorrhage, inflammatory infiltrates and nodules. Interstitial disease (ILD) increasingly recognized among patients AAV. However, little known concerning risk factors clinical course these patients. Objectives: The aim our study was to characterize the prevalence ILD Methods: We have performed a retrospective single-centre observational analysis...
Baroreflex function is an independent marker of prognosis in heart failure (HF). However, little known about its relation to response cardiac resynchronization therapy (CRT). The aim this study assess arterial baroreflex HF patients who are candidates for CRT. population consisted 25 with indication CRT, aged 65±10 years, NYHA functional class ≥III 52%, QRS width 159±15 ms, left ventricular ejection fraction (LVEF) 29±5%, end-systolic volume (LVESV) 150±48 ml, B-type natriuretic peptide...
Background Status epilepticus (SE) is a medical condition that bestows substantial morbidity and mortality. Literature scarce regarding SE in elderly patients, particularly the context of internal medicine wards. Aim To characterize patients admitted to an ward, identify potential outcome predictors differences between young elderly, as well convulsive (CSE) non-convulsive (NCSE) patients. Methods We enrolled 135 consecutive observational, retrospective cohort study. established more than 64...
Abstract Background Over the past two decades, European Society of Cardiology (ESC) Clinical Practice Guidelines (CPG) on Heart Failure has increasingly become a familiar part practice and are used worldwide. By creating objective standards, CPG provides mechanism to assess decision-making straightforward references for clinicians. Level Evidence C recommendations based expert consensus and/or small retrospective studies registries with limited non-representative populations evaluated. The...
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Background: Classification of ANCA-associated vasculitis (AAV) has emerged in order to identify more homogenous subgroups patients with granulomatosis polyangiitis (GPA) or microscopic (MPA). However, the exact value classifying according antibody specificity (proteinase 3 [PR3] myeloperoxidase [MPO]) is still unclear. Objectives: To assess demographic, clinical and prognostic differences among AAV patients, clinicopathological classification (GPA vs . MPA) (PR3 MPO) a single-centre cohort....
Wilson's disease is a rare autosomal recessive condition. A defect on the copper carrier protein ATP7B prevents excretion of copper, which then accumulates in several organs. The prognosis favourable if diagnosis made early. Leipzig criteria standardized phenotypic classification and diagnostic criteria, thus simplifying approach. search for mutations not necessary purposes studies genotype–phenotype correlation have produced any conclusive evidence so far. More information needed to...