A new approach to the synthesis of prostaglandins, designed with following objectives in mind, is reported. The were: 1) control stereochemistry; 2) all primary prostaglandins and a variety analogs from single precursor; 3) optical resolution at an early stage. fifteenth step yielded dl-prostaglandin F2 alpha identical natural hormone. Step by routes stereochemistry are depicted text.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of Prostaglandins F2α and E2 as the Naturally Occuring FormsE J. Corey, Thomas K. Schaaf, Willy. Huber, Urs. Koelliker, Ned M. WeinshenkerCite this: Am. Chem. Soc. 1970, 92, 2, 397–398Publication Date (Print):January 1, 1970Publication History Published online10 December 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/ja00705a609https://doi.org/10.1021/ja00705a609research-articleACS PublicationsRequest reuse...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew reagents for stereoselective carbonyl reduction. Improved synthetic route to the primary prostaglandinsElias J. Corey, Sem M. Albonico, Urs Koelliker, Thomas K. Schaaf, and Ravi VarmaCite this: Am. Chem. Soc. 1971, 93, 6, 1491–1493Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/ja00735a033https://doi.org/10.1021/ja00735a033research-articleACS...

For many practical applications of speech recognition systems, it is desirable to have an estimate con dence for each hypothesized word, i.e. which words the recognizer's output are likely be correct and not reliable.Many o f t d a y's systems use word lattices as compact representation set alternative hypothesis.We exploit such information sources measure-of-con tagger JANKA 1 .In experiments on spontaneous human-to-human data lattice related signi cantly improves tagging accuracy.

Oral communication is transient, but many important decisions, social contracts and fact findings are first carried out in an oral setup, documented written form later retrieved. At Carnegie Mellon University's Interactive Systems Laboratories we have been experimenting with the documentation of meetings. The paper summarizes part progress that made this test bed, specifically on question automatic transcription using large vocabulary continuous speech recognition, information access...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific total synthesis of prostaglandins E3 and F3.alpha.Elias J. Corey, Haruhisa Shirahama, Hisashi Yamamoto, Shiro Terashima, A. Venkateswarlu, Thomas K. SchaafCite this: Am. Chem. Soc. 1971, 93, 6, 1490–1491Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://doi.org/10.1021/ja00735a032RIGHTS & PERMISSIONSArticle Views1288Altmetric-Citations98LEARN ABOUT THESE...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of prostaglandins F1.alpha., E1, F2.alpha., and E2 (natural forms) from a common synthetic intermediateElias J. Corey, Ryozi Noyori, Thomas K. SchaafCite this: Am. Chem. Soc. 1970, 92, 8, 2586–2587Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/ja00711a083https://doi.org/10.1021/ja00711a083research-articleACS PublicationsRequest reuse...

For many practical applications of speech recognition systems, it is desirable to have an estimate confidence for each hypothesized word, i.e. which words the output recognizer are likely be correct and not reliable. We describe development measure tagger JANKA, able provide information at JANUS-3-SR. On a spontaneous German human-to-human database, JANKA achieves tagging accuracy 90% baseline word 82%.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew extensions of the bicyclo[2.2.1]heptane route to prostaglandinsJasjit S. Bindra, A. Grodski, Thomas K. Schaaf, and E. J. CoreyCite this: Am. Chem. Soc. 1973, 95, 22, 7522–7523Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ja00803a061https://doi.org/10.1021/ja00803a061research-articleACS PublicationsRequest reuse permissionsArticle...

Multi-label document classification (MLDC) problems can be challenging, especially for long documents with a large label set and long-tail distribution over labels. In this paper, we present an effective convolutional attention network the MLDC problem focus on medical code prediction from clinical documents. Our innovations are three-fold: (1) utilize deep convolution-based encoder squeeze-and-excitation networks residual to aggregate information across learn meaningful representations that...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological activity of carboxyl-terminus modified prostaglandin analogsThomas K. Schaaf Hans Juergen HessCite this: J. Med. Chem. 1979, 22, 11, 1340–1346Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/jm00197a012https://doi.org/10.1021/jm00197a012research-articleACS PublicationsRequest reuse permissionsArticle...

Longxiang Zhang, Renato Negrinho, Arindam Ghosh, Vasudevan Jagannathan, Hamid Reza Hassanzadeh, Thomas Schaaf, Matthew R. Gormley. Findings of the Association for Computational Linguistics: EMNLP 2021.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic furocoumarins. IX. New synthetic route to psoralenLeonard R. Worden, Kurt Dunn Kaufman, James A. Weis, and Thomas K. SchaafCite this: J. Org. Chem. 1969, 34, 8, 2311–2313Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/jo01260a015https://doi.org/10.1021/jo01260a015research-articleACS PublicationsRequest reuse permissionsArticle...

This paper describes an approach to detect out-of-vocabulary words in spontaneous speech using a language model built on semantic categories and new type of generalized word models consisting mixture specific general acoustic units. We demonstrate the construction as replacements for surnames German travel planning task GSST [1]. show that use our improves recognition accuracy cases where appear does not lead degradation overall accuracy. In experiments we measured recall precision rates...

Production scheduling in industrial practice is still primarily a manual task, despite immense research efforts and the fact that very complex task. In this paper, allocation of tasks between systems human schedulers for various types production units addressed. The factor described using existing models from cognitive psychology. sub-tasks discussed, based on characteristics systems. These are shown to depend type unit be scheduled. Four case studies illustrate theoretical framework.

We describe a feature extraction method for general audio modeling using temporal extension of Independent Component Analysis (ICA) and demonstrate its utility in the context sound classification task kitchen environment. Our approach accounts dependencies over multiple analysis frames much like standard technique adding first second derivatives to set. Using real-world dataset sounds, we show that our outperforms canonical version this front end, mel-frequency cepstral coefficients (MFCCs),...

In an effort to develop tissue-selective prostaglandin analogues resistant the metabolic inactivating pathways of natural materials, hybrid compounds modified both at C-1 with a sulfonimide moiety and in n-amylcarbinol side chain substituted phenoxy groups were synthesized evaluated variety vitro models. Several these exhibited potent, tissue-selective, uterine stimulant activity, finding subsequently confirmed clinical studies one member this series,...

Archiving, indexing, and later browsing through stored presentations lectures is increasingly being used. We have investigated the special problems advantages of propose design adaptation a speech recognizer to lecture such that recognition accuracy can be significantly improved by prior analysis presented documents using class-based language model. define tracking measure which measures how well system automatically align recognized words with parts presentation show exploitation documents,...

Nowadays official documents have to be made available in many languages, like for example the EU with its 20 languages. Therefore, need effective tools aid multitude of human translators their work becomes easily apparent. An ASR system, enabling translator speak his translation an unrestricted manner, instead typing it, constitutes such a tool. In this we improve recognition performance system on target language by taking advantage either written or spoken source representation. To do so,...

Abstract One of the main concern in O&G business is generating reliable production profile forecasts. Such profiles are cornerstones optimal technico-economical management decisions. A workflow combining different methodologies to integrate and reduce most subsurface uncertainties using multiple history matched models (explaining past) infer reasonably forecasts proposed. Using experimental design theory, a sensitivity study first performed scan whole range static dynamic uncertain...

ADVERTISEMENT RETURN TO ISSUEPREVArticleTotal synthesis of prostaglandins F1.alpha. and E1Thomas K. Schaaf E. J. CoreyCite this: Org. Chem. 1972, 37, 18, 2921–2922Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/jo00983a037https://doi.org/10.1021/jo00983a037research-articleACS PublicationsRequest reuse permissionsArticle Views340Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views...