A5068379241- Surfactants and Colloidal Systems
- Analytical Chemistry and Chromatography
- Environmental Chemistry and Analysis
- Lipid Membrane Structure and Behavior
- Antimicrobial agents and applications
- Organophosphorus compounds synthesis
- Protein Interaction Studies and Fluorescence Analysis
- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Phosphorus compounds and reactions
- Ionic liquids properties and applications
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photochemistry and Electron Transfer Studies
- Advancements in Transdermal Drug Delivery
- DNA and Nucleic Acid Chemistry
- Polydiacetylene-based materials and applications
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Molecular Sensors and Ion Detection
- Thermodynamic properties of mixtures
- Protein purification and stability
- Inhalation and Respiratory Drug Delivery
A.E. Arbuzov Institute of Organic and Physical Chemistry
2014-2025
Kazan Scientific Center
2022
Kazan Federal University
2016
Russian Academy of Sciences
2014
New hybrid liposomes based on cationic amphiphiles with different structures of the head group (cetyltrimethylammonium bromide (CTAB), 3-hexadecyl-1-hydroxyethylimidazolium (IA-16(OH)), 1-(butylcarbamoyl)oxyethyl-3-hexadecylimidazolium (IAC 16(Bu)), and hexadecylmethylpyrrolidinium (PR-16)) were developed for transdermal administration nonsteroidal anti-inflammatory drugs. The surfactant/lipid compositions studied to obtain stable high functionality. hydrodynamic diameter was ∼110 nm. An...
Novel cationic amphiphiles of the 3-alkyl-1-(4-methoxyphenyl)-1H-imidazol-3-ium bromide series bearing methoxyphenyl fragments (MPI-n) have been synthesized. Their aggregation properties in aqueous solutions, solubilization capacity, and hemolytic antimicrobial activities investigated by a number physicochemical methods. Using tensiometry, conductometry, fluorescence spectroscopy, it was shown that MPI-n lower CMCs than their nonfunctionalized counterparts. The unusual...
A synthesis procedure and aggregation properties of a new homologous series dicationic gemini surfactants with dodecane spacer two carbamate fragments (N,N'-dialkyl-N,N'-bis(2-(ethylcarbamoyloxy)ethyl)-N,N'-dimethyldodecan-1,6-diammonium dibromide, n-12-n(Et), where n = 10, 12, 14) were comprehensively described. The critical micelle concentrations obtained using tensiometry, conductometry, spectrophotometry, fluorimetry. thermodynamic parameters adsorption micellization, i.e., maximum...
One of the main problems in treatment poisoning with organophosphorus (OPs) inhibitors acetylcholinesterase (AChE) is low ability existing reactivators AChE that are used as antidotes to cross blood-brain barrier (BBB). In this work, modified cationic liposomes were developed can penetrate through BBB and deliver reactivator pralidoxime chloride (2-PAM) into brain. Liposomes obtained on basis phosphatidylcholine imidazolium surfactants. To obtain composition optimized terms charge,...
Chitosan-decorated liposomes were proposed for the first time intranasal delivery of acetylcholinesterase (AChE) reactivator pralidoxime chloride (2-PAM) to brain as a therapy organophosphorus compounds (OPs) poisoning. Firstly, chitosome composition based on phospholipids, cholesterol, chitosans (Cs) different molecular weights, and its arginine derivative was developed optimized. The use polymer modification led an increase in encapsulation efficiency toward rhodamine B (RhB; ~85%) 2-PAM...
This study was aimed at the investigation of supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) polyanions (polyacrylic acid (PAA) human serum albumin (HSA)), factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed PE-surfactant complexes oppositely charged species are characterized by multifactor strongly affected nature both components. It expected that...
Cerasomes are a promising modification of liposomes with covalent siloxane networks on the surface that provide outstanding morphological stability while maintaining all useful traits liposomes. Herein, thin film hydration and ethanol sol injection methods were utilized to produce cerasomes various composition, which then evaluated for purpose drug delivery. The most nanoparticles obtained by method studied closely using MTT assay, flow cytometry fluorescence microscopy T98G glioblastoma...