A5087770147- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
Seven Bridges Genomics (United States)
2017-2019
Boston University
2013-2017
Abstract The human reference genome serves as the foundation for genomics by providing a scaffold alignment of sequencing reads, but currently only reflects single consensus haplotype, which impairs read and downstream analysis accuracy. Reference structures incorporating known genetic variation have been shown to improve accuracy genomic analyses, so far remained computationally prohibitive routine large-scale use. Here we present graph implementation that enables across 2,800 diploid...
Abstract Length polymorphisms in genomic short tandem repeats have been implicated a variety of diseases, most notably human neurodegenerative disorders. Expansions are also associated with instability cancer. Our previous study length-3 uncovered surprising pattern the length distribution certain such non-coding regions reference genome: bias towards 3 n - 1, ( > 3). That is, observed frequency this genome is higher than expected by chance based on shorter repeats. We hypothesized that...
Abstract High expression of immunoglobulin transcripts is often detected in human tumours and correlates with favourable clinical outcomes across different cancer types. However, the antigens recognized by such immunoglobulins (Ig) their biological significance remain largely unknown. We computationally inferred paired sequence thousands clonally expanded Ig using bulk RNA sequencing data from solid tumors The Cancer Genome Atlas (TCGA). After expressing 283 as recombinant antibodies...