A5019730393- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- Biomedical Ethics and Regulation
- Chronic Lymphocytic Leukemia Research
- Electronic Health Records Systems
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacy and Medical Practices
- Fungal Infections and Studies
- Digital Rights Management and Security
- Blood disorders and treatments
- Chemotherapy-related skin toxicity
- Diverse Scientific Research Studies
- Cystic Fibrosis Research Advances
- Polyomavirus and related diseases
- Medical Coding and Health Information
- Antifungal resistance and susceptibility
- Business Process Modeling and Analysis
- Family Support in Illness
- Healthcare Systems and Technology
University of Iowa Hospitals and Clinics
2015-2021
University of Iowa Holden Comprehensive Cancer Center
2017
University of Iowa
2014-2015
Response to treatment in patients with a plasma cell disorder is typically measured by evaluating the bone marrow and myeloma markers, including monoclonal protein spike immunofixation ( IFE ) blood urine, serum free light chains sFLC s). Stringent complete response criteria for Multiple Myeloma MM require normal FLC ratio absence of clonal cells immunohistochemistry or immunofluorescence. We performed retrospective chart review further evaluate these criteria. A total 142 patient charts...
Abstract: The addition of cytotoxic drugs to high-dose melphalan as a preparative regimen for autologous stem cell transplantation in multiple myeloma has not resulted superior activity. Although novel agents have significantly improved outcome myeloma, their role regimens remains largely unknown. We evaluated the toxicity and efficacy combining bortezomib, thalidomide, dexamethasone with melphalan. An institutional review board-approved retrospective analysis was performed on 100...
Objective: To estimate the incidence of IFD in multiple myeloma patients receiving autologous stem cell transplantation (ASCT) using novel agents (bortezomib, thalidomide) addition to high-dose melphalan (VTD Mel). Patients and methods: Retrospective chart review who received an ASCT with regimen VDT Mel between 2012 2014 at UIHC. All toxicities related transplant were calculated for first 100 days after ASCT. classified as proven, probable possible according EORTC/MSG revised...
BackgroundMany studies showed that novel agent based regimens result in superior response rates and depth. Recommended practice prior to ASCT TE, NDMM is induction therapy. While one CIBMTR study did not find an impact of intensity therapy on overall outcomes, several other a significant impact. The value the context tandem using conditioning well studied.Patients methodsAll sequential patients who received planned at our center between 2012 2015 were included analysis. We compared outcomes...
7041 Background: BuCy is considered a standard myeloablative conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT). However its use limited by significant related toxicity. Several reports suggest that the combination of busulfan and fludarabine(BuFlu) in ablative doses may provide effective control myeloid neoplasms with less This study evaluated effect replacing BuFlu neoplasms. Methods: Retrospective analysis patients (pts) who underwent HSCT after or between...
Background: While preparing for our 2017 FACT inspection, we identified a need system to allow more centralized storing and tracking of critical documents. As designed system, recognized the potential develop comprehensive solution encompass all quality management aspects furthermore, dynamic mapping feature map relationships between 6th Edition Standards corresponding internal SOPs, audits, events other documentation housed within database. Methods: Our Medical Director, Assistant Program...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for many hematologic conditions and associated with considerable morbidity mortality. Therefore, prognostic tools are essential to navigate the complex patient, disease, donor, transplant characteristics that differentially influence outcomes. We developed novel, comprehensive composite tool. Using lasso-penalized Cox regression model (n = 273), performance status, HCT-CI, refined disease-risk index (rDRI), donor...
Requesting follow-up information on BMT patients from external providers is an ongoing task for staff. By automating the faxing request process, UIHC Data Team saves time and resources by eliminating need to edit track paper documents reducing printing supply costs.
Accurate and efficient BMT data collection is essential for outcomes analyses program administration as well meeting external reporting requirements. As technological innovation has driven the transition from paper-based charts to electronic medical records (EMRs), a rapid development of software products designed work alongside EMRs taken place provide programs with ability analyze manipulate their in real-time. Although promising efforts are underway improve current integrate separate...
Accurate reporting of adverse events (AEs) facilitates analyses new and approved therapies is a federal requirement for clinical research. Healthcare professionals utilize the Common Terminology Criteria Adverse Events (CTCAE) this reporting. Our group reviewed documentation within our hospital's EMR Epic® subset over 100 transplants performed in 2012-2013 collected data toxicities meeting grades 3 or higher into shared project-specific Access® database which tied to program BMT database. We...
Rapid evaluation and antibiotic therapy for febrile bone marrow transplant (BMT) patients is critical to decrease morbidity mortality from infection, but identifying these in a large medical system can be challenging. This study measures the effect of computerized triage support implemented an Emergency Department (ED) electronic record (EMR) on time administration other time-sensitive measures. We hypothesize that will vitals, blood cultures, antibiotics, unit transfer. A before-after...
Tandem autologous transplants have been proven to be an effective treatment in multiple myeloma (MM) patients. However, few studies examined CMV and HHV-6 reactivation after tandem peripheral blood stem cell transplantation (APBSCT). Herein, we present the results from our institution. Records of patients with MM who received transplant at institute between 03/01/12-09/01/15 were reviewed for reactivation. serostatus was determined all before using a chemiluminescent immunoassay. Routine...
The best conditioning regimen for patients (pts) undergoing unrelated myeloablative allogeneic hematopoietic stem cell transplant (Allo-HSCT) is not known. combination of Busulfan (Bu) and fludarabine (Flu) has shown a good safety profile with low toxicity. We conducted retrospective analysis Allo-HSCTs BuFlu performed between 2007 2015. included both matched mismatched HSCT across all indications. consisted IV Flu 40 mg/m2 Bu 130 on days -6 to -3. Tacrolimus, methotrexate thymoglobulin were...
Supportive system and socioeconomic status have influence on the outcomes in several medical conditions. Patients who underwent allogeneic hematopoietic stem cell transplant (Allo-HSCT) require close follow-up well-coordinated post-transplant care. These non-biologic factors are not well-studied Allo-HSCT setting. We conducted a retrospective analysis of all patients between 2005 2015. Non-biologic variables including marital status, distance from center, occupation, household income,...
Improving the Reporting of Cytogenetics and Molecular Markers In 2013 CIBMTR began requesting cytogenetics molecular markers data to be reported on Pre-TED for all patients. We found that organizing entry process improved our reporting accuracy this complex data. also utilizing a split screen feature recipients with multiple transplants assured greater among transplants. Our team downloaded Data Back Centers (DBtC) files create database template. Hover tips were programmed provide staff...
Blood and marrow transplant (BMT) programs are federally required to report pre-transplant post-transplant outcomes data the CIBMTR. Programs employ managers review medical records this registry. Data staff also collect compile for physicians, insurance payor requests information (RFIs), internal quality assurance needs. Accurate efficient BMT collection is essential analyses program administration as well meeting external reporting requirements. The University of Iowa Marrow Transplant Team...
e18000 Background: The best conditioning regimen for patients undergoing myeloablative hematopoietic stem cell transplantation (HSCT) is unknown. Busulfan (Bu) and fludarabine (Flu) containing regimens have shown a good safety profile with low toxicity. A retrospective analysis of (pts) myeloid neoplasms (AML/MDS/CML) who underwent allogeneic HSCT between 2008 2012 dose busulfan here reported. Methods: total 45 pts were included in the analysis. Twenty eight (62.2%) had AML, 15 (33.3%) MDS 2...
e18003 Background: The utility of routine chimerism analysis following allogeneic HSCT with myeloablative conditioning remains controversial and its impact on relapse survival is unclear. In this single-center study we evaluated the CD3+ T-lymphocyte in patients (pts) undergoing busulfan containing for myeloid neoplasms. Methods: A retrospective review 184 pts neoplasms at our institution from 2003-2013 was performed. Of group, 99 had studies Median age 55 (range 19-74) 63 having AML, 7 CML...
Accurate reporting of adverse events (AEs) facilitates analyses new and approved therapies is a federal requirement for clinical research. Healthcare professionals utilize the Common Terminology Criteria Adverse Events (CTCAE) this reporting. Our group reviewed documentation within our hospital's EMR Epic® subset over 100 transplants performed in 2012-2013 collected data toxicities meeting grades 3 or higher into shared project-specific Access® database which tied to program BMT database. We...