A5030086539- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
Stonehill College
2020-2022
Abstract Identification of mechanisms which increase deep sleep could lead to novel treatments promote the restorative effects sleep. Here, we show that knockdown α3 GABA A -receptor subunit from parvalbumin neurons in thalamic reticular nucleus using CRISPR-Cas9 gene editing increased thalamocortical delta (1.5–4 Hz) oscillations are implicated many health-promoting Inhibitory synaptic currents were strongly reduced vitro. Further analysis revealed power long NREM bouts prior NREM-REM...
Abstract Identification of mechanisms which increase deep sleep could lead to novel treatments promote the restorative effects sleep. Here, knockdown α3 GABA A -receptor subunit from parvalbumin neurons in thalamic reticular nucleus using CRISPR-Cas9 gene editing increased thalamocortical delta oscillations implicated many health-promoting Inhibitory synaptic currents were strongly reduced vitro . Effects most pronounced mouse (light) period. Further analysis identified a deep-sleep state...