A5031404406- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and exercise physiology
- Congenital Heart Disease Studies
- Cardiac Health and Mental Health
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Cardiovascular Issues in Pregnancy
University of Wisconsin–Madison
2018-2025
Madison Area Technical College
2018-2019
Chenguang Research Institute of Chemical Industry
2018
Hypoxic pulmonary hypertension (HPH) develops in association with diseases characterized by low oxygen levels leading to artery (PA) narrowing and death. Hypoxia has been linked increased PA collagen changes adventitial fibroblast (PAAF) metabolism. However, the mechanisms which hypoxia regulates PAAF function are unknown. Hypoxia-inducible factor-1α (HIF-1α) is a subunit of transcription factor that degraded normoxia but stabilized involved extracellular matrix remodeling fibroblasts. We...
Right ventricular (RV) failure (RVF) is the major cause of death in pulmonary hypertension. Recent studies have characterized changes RV structure RVF, including hypertrophy, fibrosis, and abnormalities mitochondria. Few, if any, explored relationships between these multiscale structural functional RVF. Pulmonary artery banding (PAB) was used to induce RVF due pressure overload male rats. Eight weeks postsurgery, terminal invasive measurements demonstrated with decreased ejection fraction...
Sex differences in right ventricular mechanical efficiency and energetic adaptation to increased afterload were measured. Despite sex-dependent contractile fibrotic responses, mechanoenergetic was comparable between the sexes, suggesting a homeostatic target.
Background: Pulmonary arterial hypertension (PAH) occurs more often in women, but women exhibit better survival. Rodent models of PAH suggest a right ventricular (RV) protective effect estrogen signaling through receptor alpha (ERα). While regulates mitochondrial biogenesis and function, the role ERα preserving RV function setting pressure overload is unknown. Methods: Estrogen knockout (ERKO) rats were created using CRISPR/Cas9 system. Male female ERKO littermate control (WT) underwent...