A5059146216- biodegradable polymer synthesis and properties
- Polymer crystallization and properties
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Polymer Nanocomposites and Properties
- Mycorrhizal Fungi and Plant Interactions
- Nuclear Materials and Properties
- Hydrogen embrittlement and corrosion behaviors in metals
- Polymer composites and self-healing
- Water resources management and optimization
- Carbon dioxide utilization in catalysis
- Additive Manufacturing and 3D Printing Technologies
- Pluripotent Stem Cells Research
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pancreatic function and diabetes
- Pineapple and bromelain studies
- Microplastics and Plastic Pollution
- Renal and related cancers
- Hippo pathway signaling and YAP/TAZ
- Congenital heart defects research
- Electrospun Nanofibers in Biomedical Applications
- Water Systems and Optimization
- Polymer Foaming and Composites
- Effects and risks of endocrine disrupting chemicals
Beijing Institute of Petrochemical Technology
2013-2025
University of California, San Diego
2017-2025
Hohhot First Hospital
2024
Fudan University
2013-2024
SGIDI Engineering Consulting (China)
2023-2024
Henan Institute of Science and Technology
2022-2023
Yunnan Academy of Forestry
2022
University of Wisconsin–Madison
2015-2021
Beijing Meteorological Bureau
2021
North China Electric Power University
2012-2019
Pdgfra-expressing (Pdgfra+) cells have been implicated as progenitors in many mesenchymal tissues. To determine lineage potential, we generated PdgfrartTA knockin mice using CRISPR/Cas9. During lung maturation, counter to a prior study reporting that Pdgfra+ give rise equally myofibroblasts and lipofibroblasts, tracing PdgfrartTA;tetO-cre indicated ~95% of the lineaged are myofibroblasts. Genetic ablation PdgfrartTA-driven diphtheria toxin (DTA) led alveolar simplification, demonstrating...
The human lung plays vital roles in respiration, host defense, and basic physiology. Recent technological advancements such as single-cell RNA sequencing genetic lineage tracing have revealed novel cell types enriched functional properties of existing lung. time has come to take a new census. Initiated by members the NHLBI-funded LungMAP Consortium aided experts biology community, we synthesized current data into comprehensive practical cellular census Identities normal are captured...
Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating procontractile prosurvival peptide apelin via a BMPR2-dependent mechanism. found ER-α expression were decreased in homogenates from patients RVF rats maladaptive (but not adaptive) remodeling....
The echelon utilization of retired lithium-ion battery with remaining capacity 80%, is considered as one the most promising ways to reduce cost by extending their service life. accurate state charge (SOC) estimation for batteries great significance less-stressful demanding applications. H-infinity filter (HIF) widely used identify model parameters and correspondingly estimate SOC online assisted Thevenin model. But accuracy cannot be ensured due overly simple algorithm structure. In this...
A majority (~95%) of the gas-exchange surface area is generated through septa formation during alveologenesis. Disruption this process leads to alveolar simplification and bronchopulmonary dysplasia (BPD), a prevalent disorder in premature infants. Although several models have been proposed, mechanism remains under debate. Here we show that inactivation myosin light chain kinase (MLCK), key factor required for myofibroblast contraction, disrupted formation, supporting contraction model The...
A low molecular weight hydrazide compound, tetramethylenedicarboxylic di (2-hydroxybenzohydrazide) (TMBH), greatly improves the crystallization rate and crystallinity of poly(l-lactide) (PLLA). The nucleating efficiency TMBH on PLLA exhibits obvious concentration dependence, which increases first then decreases slightly with increase loading, reaching a maximum at 0.3 wt%. Time-resolved Fourier transform infrared spectroscopy spectra indicate that formation skeletal conformational ordering...
Summary The stable genomic integration and expression of a large transgene is major hurdle in gene therapy. We show that the modified piggyBac (PB) transposon system can be used to introduce 207 kb DNA fragment containing RORγ/γt locus into human cells mice. PB-mediated transgenesis results single copy stably inherited expressed transgene. These indicate PB could serve as an effective high-capacity vector for functional analysis mammalian genome therapy cells.
Alveologenesis, the final step of lung development, is characterized by formation millions alveolar septa that constitute vast gas-exchange surface area. The genetic network driving alveologenesis poorly understood compared with earlier steps in development. FGF signaling through receptors Fgfr3 and Fgfr4 crucial for alveologenesis, but mechanisms which they mediate this process remain unclear. Here we show Fgfr3;Fgfr4 (Fgfr3;4) global mutant mice, simplification first observed at onset...
Styrene – glycidyl acrylate copolymer Joncryl ADR4368 (ADR) was employed as a compatibilizer in the immiscible blends of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL). The morphology, crystallization behavior mechanical properties were investigated. compatibility between PLA PCL poor, thus leading to poor tensile for PLA/PCL blends. addition ADR reduced size domains due formation long chain branched copolymers interface, indicating improved PCL. enhanced cold ability PLA, while...
Although women are more susceptible to pulmonary arterial hypertension (PAH) than men, their right ventricular (RV) function is better preserved. Estrogen receptor-α (ERα) has been identified as a likely mediator for estrogen protection in the RV. However, role of ERα preserving RV and remodeling during pressure overload remains poorly understood. We hypothesized that loss functional removes female from adverse permissive development maladapted phenotype. Male rats with loss-of-function...
Abstract The structure and properties of incompatible polylactide (PLA)/polyamide elastomer (PAE) blends were tailored by a chain extender specifically the styrene–glycidyl acrylate copolymer Joncryl ADR4368 (ADR). Various PLA/PAE/ADR with different compositions prepared melt blending, their morphology, crystallization behavior, mechanical shape memory systematically investigated. results showed uniform dispersion PAE particles in PLA matrix for reduction particle size upon addition ADR. was...
Plant amino acid transporters play an important role in the absorption of soil acids by roots, transport between xylem and phloem, plant growth development, response to abiotic stress. In this study, we identified 147 AAT genes quinoa genome sequence categorized them into 12 subfamilies on basis their similarity phylogenetic relationships with found Arabidopsis thaliana. Interestingly, these are not evenly distributed chromosomes. Instead, most centrally located outer edges chromosome arms....
ABSTRACT The impact of the nucleating agent N ‐(3‐(hydrazyl) benzoyl)‐1‐naphthylhydrazide (HBNA) on crystallization behavior, optical characteristics, mechanical and shape memory properties polylactide (PLA)/polyvinyl acetate (PVAc) blends was systematically investigated. addition HBNA maintained homogeneity PLA/PVAc blends, resulting in an evident glass transition temperature ( T g ) between PLA PVAc. Both non‐isothermal isothermal rates were accelerated, accompanied by a consistent Avrami...
A new improved shuffled frog leaping algorithm (SFLA), the chaos catfish effect SFLA (CCESFLA), is proposed by coupling a local "refine search" mechanism and "global incentive adjustment" mechanism. Chaotic technology introduced in to improve search ability, implementing more refined around optimal individuals. The adopted global convergence, motivating frogs "jump out" of steady state. operation optimization CCESFLA carried out taking Li Xianjiang cascade reservoirs China as an example....
Purpose Public–private partnership (PPP) projects are increasingly significant in many countries. The purpose of this paper is to assess the impact critical success factors (CSFs) on PPP and comprehensively consider interrelations interaction among dimensions achieve a better understanding project management. Design/methodology/approach An evaluation index system for such as presented case study proposed based literature review survey. Then, interpretative structural modeling used transform...