A5039573714- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- melanin and skin pigmentation
- Coronary Interventions and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Neonatal Respiratory Health Research
- Lung Cancer Research Studies
- Identification and Quantification in Food
- Cell Adhesion Molecules Research
- Lung Cancer Treatments and Mutations
- Renal and related cancers
- Vascular Procedures and Complications
- Medical Imaging and Pathology Studies
- Pluripotent Stem Cells Research
- Cerebrospinal fluid and hydrocephalus
- Aortic aneurysm repair treatments
- Head and Neck Cancer Studies
- Fetal and Pediatric Neurological Disorders
- Blood groups and transfusion
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Venous Thromboembolism Diagnosis and Management
University of California, San Diego
2025
Kurashiki Central Hospital
2011-2024
Kyoto University Hospital
2021-2024
Kyoto University
2013-2022
University of Occupational and Environmental Health Japan
2009-2018
The University of Kitakyushu
2018
University Hospital of Zurich
2015
Toshiba (Japan)
2009
Kumamoto University
1991-2004
Kumamoto City Hospital
1996
Our purpose was to evaluate the relationships between ratio of maximum relative cerebral blood volume (rCBV) (rCBV = rCBV[tumor]/rCBV[contralateral white matter]) and histologic angiographic vascularities gliomas using gradient-echo echoplanar MR imaging technique. We also evaluated usefulness rCBV maps for grading gliomas.We examined 30 patients with histologically verified gliomas. Gliomas were classified as glioblastoma, anaplastic glioma enhancement, without low-grade glioma. The each...
No methods for isolating induced alveolar epithelial progenitor cells (AEPCs) from human embryonic stem (hESCs) and pluripotent (hiPSCs) have been reported.Based on a study of the stepwise induction (AECs), we identified carboxypeptidase M (CPM) as surface marker NKX2-1 + ''ventralized'' anterior foregut endoderm (VAFECs) in vitro fetal murine lungs.Using SFTPC-GFP reporter hPSCs 3D coculture system with lung fibroblasts, showed that CPM isolated VAFECs differentiate into AECs, demonstrating...
Highlights•HPS2-iPSCs and cHPS2-iPSCs were generated from HPS2 patient fibroblasts•Anti-NaPi2b antibody was useful for isolating AT2 cells human lung AOs•The enlargement abnormal distribution of LBs observed in HPS2-AOs•Impaired surfactant secretion demonstrated HPS2-AOsSummaryIt has been challenging to generate vitro models alveolar diseases, as the stable culture type 2 (AT2) difficult. Methods generating expanding derived induced pluripotent stem (iPSCs) have established are expected be...
Combined induced pluripotent stem cells and airway-on-a-chip establish the global axis of planar cell polarity in patient-derived airway sheet.
The purpose of this study was to assess the initial clinical response superselective intraarterial infusion cisplatin for treating stage III and IV squamous cell carcinoma mouth.Thirteen patients received therapy. tumors were located in tongue (n = 7), gingiva 3), buccal mucosa 1), hard palate floor mouth 1). A coaxial technique used place microcatheters lingual, facial, inferior alveolar, buccinator, distal internal maxillary arteries, depending on tumor location. feeding vessels identified...
PURPOSE: To evaluate the effect of aging and cerebrovascular diseases on T2 shortening in motor cortex at magnetic resonance (MR) imaging. MATERIALS AND METHODS: High-field-strength (1.5-T) MR images 298 neurologically normal patients (157 male patients, 141 female patients; age range, 2-86 years) 107 with (66 men, 41 women; 41-86 were evaluated retrospectively. On T2-weighted spin-echo images, signal intensities motor, sensory, parietal, temporal, prefrontal cortices divided into three...
To assess the diagnostic accuracy of three-dimensional (3D) magnetic resonance (MR) images in preoperative evaluation hemifacial spasm.In 27 patients with surgically confirmed spasm, axial source from 3D time-of-flight MR angiography were evaluated for symptomatic sides and 26 asymptomatic by three observers a blinded manner neurovascular compression identification compressive vessels.Sensitivity was 95% specificity 77%. Vascular on could be identified retrospectively all patients. On sides,...
We herein report the clinical and laboratory characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis (PM/DM). compared these previously published findings. Previous reports our present cases show that (ILD) PM/DM lack manifestations Raynaud's phenomenon sclerodactyly good prognoses responses to glucocorticoid therapy. These results indicate presence autoantibodies may be useful for predicting...
Abstract Background Somatic cells differentiated from patient-specific human induced pluripotent stem (iPSCs) could be a useful tool in cell-based disease research. Hermansky–Pudlak syndrome (HPS) is an autosomal recessive genetic disorder characterized by oculocutaneous albinism and platelet dysfunction. HPS patients often suffer lethal associated interstitial pneumonia (HPSIP). Lung transplantation has been the only treatment for HPSIP. Lysosome-related organelles are impaired HPS, thereby...
<h3>BACKGROUND AND PURPOSE:</h3> Optimal tube voltage and current settings are not well established. The purpose of our study was to investigate the image quality on 3D CT angiograms brain at various kilovoltage by evaluating depiction simulated intracranial lesions using a vascular phantom. <h3>MATERIALS METHODS:</h3> An anthropomorphic phantom with superimposed bone skull structures designed simulate aneurysms aneurysmal blebs. We performed angiography 64-detector row scanner for effective...
Gefitinib and erlotinib are first-generation small molecular inhibitors of EGFR tyrosine kinase activity. To the best our knowledge, to date, two reports have stated that patients with NSCLC who develop severe hepatotoxicity secondary gefitinib treatment can be safely switched erlotinib. However, reverse situation has not been reported. Here, we present first case non-small cell lung cancer harboring mutation developed grade 3/4 after initiation erlotinib, which resolved when therapy was...
Comparison of HASTE and segmented-HASTE sequences with a T2-weighted fast spin-echo sequence in the screening evaluation brain.T Sugahara, Y Korogi, T Hirai, S Hamatake, I Ikushima, Shigematu M TakahashiAudio Available | Share
A 50-year-old man with a 30-year occupational history of welding presented low-grade fever, fatigue and persistent dry cough. Computed tomography (CT) the chest revealed interlobular septal thickening bilateral non-segmental patchy ground-glass opacities except in sub-pleural zone. He that he had inhaled nickel fumes 3 days previously at work. These findings suggested diagnosis pneumonitis induced by inhalation fumes. Fewer reports describe associated compared zinc Although compounds are...
Lung transplantation is the only treatment available for end-stage lung diseases; however, donor shortage a global issue. The use of human pluripotent stem cells (hPSCs) organ regeneration promising approach. Nevertheless, methods expansion isolated hPSC-derived progenitors (hLPs) purposes have not yet been reported. Herein, we established an system hLPs based on their three-dimensional culture in core-shell hydrogel microfibers, that ensures maintenance bipotency differentiation into...
PURPOSE: To evaluate the long-term results of irradiation alone or embolization with without in patients dural carotid cavernous fistulas (DCCFs). MATERIALS AND METHODS: Between 1984 and 1996, symptomatic DCCFs 26 were treated by using (protocol 1, n = 12) before April 1988 as an initial treatment 2, 14) during after 1988. When angiography showed no improvement embolization, was added (n 6). On basis drainage flow speed, classified fast, medium, slow. RESULTS: With alone, all six slow- to...