A5003554880- Parkinson's Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Restless Legs Syndrome Research
- Dysphagia Assessment and Management
- Child Nutrition and Feeding Issues
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- GABA and Rice Research
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Biochemical effects in animals
- Nerve injury and regeneration
- Sleep and Wakefulness Research
Roche (Switzerland)
2016-2021
Van Andel Institute
2016
Queen's Medical Centre
2014
University of Nottingham
2014
University of Sheffield
2013
Parkinson's disease (PD) is characterized by the progressive appearance of intraneuronal Lewy aggregates, which are primarily composed misfolded α-synuclein (α-syn). The aggregates believed to propagate via neural pathways following a stereotypical pattern, starting in olfactory bulb (OB) and gut. We hypothesized that injection fibrillar α-syn into OB wild-type mice would recreate sequential progression Lewy-like pathology, while triggering deficits. demonstrate injected fibrils recruit...
Abstract The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption the autophagy-lysosome pathway (ALP) contribute to aggregation. Here we examined epigenetic alterations ALP appendix by deep sequencing DNA methylation at 521 genes. We identified aberrant 928 cytosines affecting 326 genes individuals with PD and widespread hypermethylation that is also seen brain PD. In mice, find changes induced chronic gut inflammation...
Alterations in the endocannabinoid system (ECS) are thought to play a role learning and memory impairments observed Alzheimer's disease (AD). We aimed determine status of brain ECS AβPPswe/PS1ΔE9 model AD. The comprises
Background: In some people with Parkinson's disease (PD), α-synuclein (αSyn) accumulation may begin in the enteric nervous system (ENS) decades before development of brain pathology and diagnosis. Objective: To determine how different types severity intestinal inflammation could trigger αSyn ENS subsequent pathology. Methods: We assessed effects modulating short- long-term experimental colitis on gut transgenic wild type mice by immunostaining gene expression analysis. effect brain, we...
Abstract Background : Intraneuronal accumulation of a-synuclein (αSyn) is key in Parkinson’s disease (PD) pathogenesis. The pathogenic process suggested to begin the enteric nervous system decades before diagnosis PD and then propagate into brain. triggers for these events are unclear but, some patients, colitis might play a critical role. Methods We administered lipopolysaccharide (LPS) or dextran sulfate sodium (DSS) assess effect different types experimental on αSyn gut transgenic wild...
Abstract Intraneuronal accumulation of α-synuclein (αSyn) is key in the pathogenesis Parkinson’s disease (PD). Published studies suggest that this process begins enteric nervous system (ENS) and propagates into brain decades before clinical diagnosis PD. The triggers mechanisms underlying αSyn remain unknown but evidence growing, immune pathways particular colitis may play a critical role. Here we demonstrate patients with inflammatory bowel (IBD) exhibit their colon. We then confirmed an...