A5075633080- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Bacterial biofilms and quorum sensing
- Diabetic Foot Ulcer Assessment and Management
- Infectious Diseases and Tuberculosis
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Peptides and Activities
- Bone fractures and treatments
- Shoulder Injury and Treatment
- Bacterial Identification and Susceptibility Testing
- Prosthetics and Rehabilitation Robotics
- Osteomyelitis and Bone Disorders Research
- Wound Healing and Treatments
- Muscle activation and electromyography studies
- Infection Control and Ventilation
- Foot and Ankle Surgery
- Botulinum Toxin and Related Neurological Disorders
- COVID-19 epidemiological studies
- Microfluidic and Bio-sensing Technologies
- Musculoskeletal synovial abnormalities and treatments
- Musculoskeletal Disorders and Rehabilitation
- Dental materials and restorations
St Olav's University Hospital
2010-2024
Norwegian University of Science and Technology
2002-2012
ABSTRACT Biofilm‐associated implant‐related bone and joint infections are clinically important due to the extensive morbidity, cost of care socioeconomic burden that they cause. Research in field biofilms has expanded past two decades, however, there is still an immense knowledge gap related many clinical challenges these biofilm‐associated infections. This subject was assigned Biofilm Workgroup during second International Consensus Meeting on Musculoskeletal Infection held Philadelphia USA...
Low-virulence implant infections are characterized by bacterial colonization of the with subsequent biofilm formation. In these cases, soft tissue biopsies often prove to be culture negative. Consequently, detachment causative adherent bacteria is crucial for correct microbiological diagnosis. Using an in vitro model, we compared 4 methods sampling from metal surfaces.Discs titanium and steel were incubated presence Staphylococcus aureus, epidermidis, Enterococcus faecalis, Propionibacterium...
The diagnosis of a chronic prosthetic joint infection (PJI) is challenging, and no consensus exists regarding how best to define the criteria required for microbiological identification. A general view that culture periprosthetic biopsies suffers from inadequate sensitivity. Recently, molecular analyses have been employed in some studies but specificity has questioned, mainly due contamination issues. In prospective study 54 patients undergoing revision surgery loosening, we focused on two...
We studied the basic release patterns of antibiotics from cancellous bone in vitro. Antibiotic-impregnated was compressed into a wire-mesh cylinder and antibiotic assessed by two different vitro methods: agar diffusion broth elution. The zones inhibition were measured on seeded amounts released elution tubes bioassay. study continued for 21 days with daily transfer cylinders. results indicated that benzylpenicillin, dicloxacillin, cephalotin, netilmicin, clindamycin, vancomycin,...
We compared the release characteristics of antibiotics from in vivo and vitro processed morselized cancellous bone. The bone was impregnated with 7 compressed into a wire-mesh cylinder. In vitro, by daily transfer cylinder its contents test tubes broth. amount antibiotic eluted measured after 1, 3 days. vivo, implanted intramuscularly interscapular region rats. After days, removed broth measured. results showed that can act as carrier vivo. elution profiles netilmicin-, vancomycin-,...
Infection can be a devastating complication after implantation of cortical bone allograft. The allograft could act as vehicle for local antibiotic prophylaxis.We studied the release antibiotics in vitro from allografts impregnated with different periods time. We also whether eradicate Staphylococcus aureus an experimentally infected graft vivo. In study, pieces were netilmicin, vancomycin, ciprofloxacin and rifampicin 1 h, 10 h 100 h. eluted into phosphate-buffered saline (PBS) 7 days, daily...
First, we studied the effect of following variables used for netilmicin- and vancomycin-impregnation cancellous bone: a) antibiotic concentration impregnation fluid, b) time impregnation, c) pH d) degree bone morselizing e) combination. An increase in fluid increased amount antibiotics released from bone. In addition, vancomycin eluted was also dependent on impregnation. The fraction total netilmicin after 24 h 80% 30%, respectively. More were impregnated with at 7 than 3. fine morselized...
Objectives: The European League Against Rheumatism (EULAR) and the Federation of National Associations Orthopaedics Traumatology (EFORT) have recognised importance variation in diagnostic therapeutic performance across disciplines, found consensus starting task forces aiming at achieving uniformity, identified medical conditions with which representatives both organisations will frequently be confronted common clinical practice. aim present work was to establish recommendations for diagnosis...
High-heeled shoes have been suggested as a main explanation for the female dominance in foot pain and deformities. Aim of study was to test this hypothesis scientifically.Women 40-66 years were included two groups. 95 women who had worn high-heeled at work least 5 compared 102 never work. The investigations weight bearing radiographs ankle, SEFAS questionnaire AOFAS Clinical Rating System. Evaluators blinded group-affiliation.Radiographs showed no statistically significant differences...
In the city of Trondheim, Norway, diabetic lower-limb amputations accounted for one-third all (LLAs). an attempt to reduce this rate, a foot team was established in 1996. We present incidence LLA Trondheim as measured 10 years later.In 2004-07, we registered LLAs performed and then compared data with previously published from 1994-1997. From 1996 through 2006, activity also number vascular procedures on citizens 1998 2006.Comparing two 3-year periods 1994-97 observed decrease non-traumatic...
When cancellous bone is impregnated with antibiotics the subsequent release of from shows a high early release. Hence, impaction large amounts netilmicin-impregnated may cause toxic netilmicin values in serum.We studied kidney and otovestibular function after impacting 50 g during revision hip or knee arthroplasty 20 patients. The was impacted acetabulum (n = 8), proximal femur 9) distal femur/proximal tibia 3). Serum creatinine concentration measured audiometry performed before operation....
Abstract Background In diagnosing chronic orthopedic implant infections culture of sonicate represents a supplement to tissue cultures. However, the extent which biofilm forms on surfaces and degree dislodgement bacteria by sonication remains unclear. this in vivo study using low bacterial inoculum, we aimed determine whether variable effect could be observed standardized model. Materials Methods Seven Wistar rats underwent surgery with intramuscular implantation two bone xenograft implants,...
The authors consecutively recorded all lower limb amputations performed at the University Hospital of Trondheim from January 1st, 1994 to 1997. A total 215 primary were carried out in study period: 40 partial foot amputations, 2 ankle disarticulations, 51 trans-tibial 68 knee 50 trans-femoral and 4 hip disarticulations. Seventy-four (74) (34%) amputees had diabetes mellitus, 113 (53%) peripheral vascular disease 28 (13%) various diagnoses. In those who amputated due diabetic overall...
Insufficiently protected healthcare workers (HCWs), defined as high-risk contacts of patients with coronavirus disease 2019 (COVID-19), are routinely quarantined. This study evaluated the transmission infection from a symptomatic patient COVID-19 to 60 HCWs exposed at ≤2 m for ≥15 min or during aerosol-generating procedures. Following ≥106 unique contacts, none tested positive severe acute respiratory syndrome coronavirus-2 RNA developed antibodies. The reported adherence basic control These...
The use of arm prosthesis in trans-humeral amputees is limited; due to the cone form amputation stump. A Humerus-T-Prosthesis was implanted three patients create artificial humerus condyles. Two were successfully rehabilitated with application a new type prosthesis. This had socket which suspended and stabilized by implant only. Traction rotational stability secured adjustable pressure adaptation around third patient developed wound over lateral part condyle that later healed. He also...
A femoral condyle endoprosthesis (FCE) was implanted in a 48-year-old transfemorally amputated woman with the intention of making amputation stump fully endbearing (Figure 1). The implant a...
The number of obese people with diabetes mellitus (DM) is increasing. DM in itself a risk factor for all types infections, including infections after total hip and knee prosthetic surgery. In particular, the prevalence obesity high among orthopaedic patients. Obesity also post-operative general. After arthroplasty patients have threefold increased compared to patient normal weight. There an association between obesity, this explained by presence metabolic syndrome. Fat tissue abdominal acts...
Abstract Introduction: Patients with soft tissue injuries caused by missile attacks during wartime have been treated radical debridement and delayed closure. In a study in Gaza City, the rate of infection to extremities when minimal surgical intervention, was measured. Methods: severe damage, compound fractures, major blood vessels and/or nerves were excluded from study. One hundred fourteen patients according standardized regime that included superficial, minor surgery revision inlet outlet...
Abstract Background In cases of prosthetic joint infections, culture sonication fluid can supplement harvested tissue samples for correct microbial diagnosis. However, discrepant results regarding the increased sensitivity have been reported in several studies. To what degree bacteria embedded biofilm are dislodged during process has to our knowledge not fully elucidated. present vitro study, we evaluated effect as a method dislodge by quantitative microscopy. Methods We used standard cover...
Abstract Background The aim of the study was to establish an experimental chronic musculoskeletal infection model in vivo characterized by (a) a small bacterial inoculum, (b) no general or local signs infection, (c) several parallels (implants) each animal and finally (d) that is technically easy perform. Methods Bone xenografts with steel plates were implanted intramuscularly rats. To xenografts, different inocula Staphylococcus aureus two strains epidermidis added. animals observed for...
Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing PCNA interacting motif APIM (APIM-peptides) were recently shown bind bacterial homolog, beta (β)-clamp, have both antibacterial anti-mutagenic activities. In this study explore effects of these peptides on Staphylococcus epidermidis , a species commonly found in prosthetic joint infections (PJI). Drug-resistant isolates from PJIs often lead difficult-to-treat...