A5062731905- Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Vascular Tumors and Angiosarcomas
- Thyroid Disorders and Treatments
- Ubiquitin and proteasome pathways
- Growth Hormone and Insulin-like Growth Factors
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Trace Elements in Health
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Chemokine receptors and signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Viral-associated cancers and disorders
- Vitamin C and Antioxidants Research
Consejo Nacional de Investigaciones Científicas y Técnicas
2012-2024
Pontificia Universidad Católica Argentina
2014-2024
Experimental Medicine and Biology Institute
2010-2023
Weill Cornell Medicine
2017
Cornell University
2017
Progesterone receptor (PR) and ErbB-2 bidirectional cross talk participates in breast cancer development. Here, we identified a new mechanism of the PR interaction involving induction nuclear translocation assembly transcriptional complex which acts as coactivator Stat3. We also highlighted that function Stat3 drives progestin-induced cyclin D1 promoter activation. Notably, is recruited together with to promoter, unraveling unexpected nonclassical genomic mechanism. The Stat3/ErbB-2 plays...
Abstract Peripheral T-cell lymphomas (PTCL) are aggressive diseases with poor response to chemotherapy and dismal survival. Identification of effective strategies target PTCL biology represents an urgent need. Here we report that sensitive transcription-targeting drugs, and, in particular, THZ1, a covalent inhibitor cyclin-dependent kinase 7 (CDK7). The STAT-signalling pathway is highly vulnerable THZ1 even cells carry the activating STAT3 mutation Y640F. In mutant cells, CDK7 inhibition...
The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance ErbB-2 localization primary invasive cancer. reporting recommendations for tumor marker prognostic studies (REMARK) guidelines were used as reference.Tissue microarrays from a cohort 273 carcinomas women living Chile, Latin American country, examined membrane (MembErbB-2) and NuclErbB-2 expression by an immunofluorescence (IF) protocol...
We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects THs on tumor development been studied, but results are still controversial. Herein, we show modulatory action status vivo growth For this purpose, euthyroid, hypothyroid, hyperthyroid mice received inoculations EL4 cells to allow solid tumors. Tumors animals exhibited a higher rate, as evidenced by early appearance palpable tumors increased volume....
The patient's hormonal context plays a crucial role in the outcome of cancer. However, association between thyroid disease and breast cancer risk remains unclear. We evaluated effect status on growth dissemination an immunocompetent mouse model. For this, hyperthyroid hypothyroid Balb/c mice were orthotopically inoculated with triple-negative 4T1 cells. Tumors from showed increased rate immunosuppressive tumor microenvironment, characterized by IL-10 levels decreased percentage activated...
The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of compound on highly metastatic murine B16-F10 human A375 We found that TAP7f inhibited cell adhesion, migration invasion a dose-dependent manner. Additionally, demonstrated downregulated integrin αvβ3 expression Wnt/β-catenin pathway, signaling...
Abstract Bexarotene is a specific retinoid X receptor agonist that has been used for the treatment of cutaneous T-cell lymphoma (CTCL). Because bexarotene causes hypothyroidism, it requires administration levothyroxine. However, levothyroxine, in addition to its ubiquitous nuclear receptors, can activate αVβ3 integrin overexpressed CTCL, potentially interfering antineoplastic effect bexarotene. We thus investigated biological levothyroxine relation treatment. Although isolated CTCL cells...
The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance ErbB-2 localization primary invasive cancer. reporting recommendations for tumor marker prognostic studies (REMARK) guidelines were used as reference. Tissue microarrays from a cohort 273 carcinomas women living Chile, Latin American country, examined membrane (MembErbB-2) and NuclErbB-2 expression by an immunofluorescence (IF)...
Abstract T cell lymphomas (TCL) are a heterogeneous group of lymphoproliferative disorders with poor prognosis. Aberrant activation JAK/STAT pathway is associated lymphoma dissemination in TCL patients. Although the FDA approved use inhibitors to target this (Ruxolitinib), significant toxic effects have been reported and their limited. Thus making an excellent opportunity study biological factors that regulate these pathways. In sense, we recently showed thyroid hormones (THs) acting through...
Thyroid carcinoma (TC) is the most common endocrine neoplasia, with its incidence increasing in last 40 years worldwide. The determination of genetic and/or protein markers for thyroid could increase diagnostic precision. Accumulated evidence shows that Protein kinase C alpha (PKCα) contributes to tumorigenesis and therapy resistance cancer. However, role PKCα TC remains poorly studied. Our group others have demonstrated PKCs can mediate proliferative effects hormones (THs) through their...
Bexarotene (Bex) is an oral retinoid-X-receptor agonist that effective for the treatment of early and advanced-stage in cutaneous T cell lymphoma. There are ongoing clinical trials to determine its role both breast cancer prevention. Unfortunately, hypothyroidism recognized as important side effect such therapy, potentially manageable by thyroid hormones (THs) co-administration. We previously found (1) physiological levels THs increased proliferation different subtypes human lymphoma...
Thyroid hormones (THs) are important regulators of cell physiology. They essential for the normal development and growth mammals, especially neural differentiation regulation metabolism immune system. THs also induce proliferation several types. In human murine T lymphomas (TCL) this effect involves participation genomic nongenomic mechanisms as it was described by use free non-cell permeable coupled to agarose (TH-ag). The classic actions thyroid involve alteration gene transcription via...
Abstract T cell non-Hodgkin lymphomas (T-NHL) are a heterogeneous group of lymphoproliferative disorders with aggressive clinical course and no specific treatments. Thyroid Hormones (TH) crucial regulators differentiation, growth metabolism. TH modulate these functions by activating canonical nuclear (TR) membrane receptors (mTR, for most cells represented RGD integrin dimers). Recent studies us showed that stimulate the proliferation T-NHLs through complimentary intracellular pathways...