A5029676893- Evolution and Genetic Dynamics
- HIV Research and Treatment
- Antibiotic Use and Resistance
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- COVID-19 epidemiological studies
- Genital Health and Disease
- Cervical Cancer and HPV Research
- RNA Interference and Gene Delivery
University of California, Los Angeles
2024
Yale University
2020
Bacteria frequently encounter selection by both antibiotics and lytic bacteriophages. However, the evolutionary interactions between phages remain unclear, in particular, whether when can drive trade-offs with antibiotic resistance. Here, we describe Escherichia coli phage U136B, showing it relies on two host factors involved different resistance mechanisms: 1) efflux pump protein TolC 2) structural barrier molecule lipopolysaccharide (LPS). Since LPS contribute to resistance, U136B should...
Coinfection with human papillomavirus (HPV) and HIV compounds the risks of developing cervical, anal, HPV-associated oral neoplasia. Safe prophylactic vaccines are available to prevent HPV infections in people HIV(PWH). Yet, vaccine efficacy duration protection remain questionable. Historically, has been suboptimal PWH compared without (PWoH).A systematic review trials was conducted using PRISMA guidelines. Outcomes interest were efficacy, immunogenicity, predictors efficacy. A secondary...