A5045208193- Cellular Mechanics and Interactions
- Traumatic Brain Injury and Neurovascular Disturbances
- Cell Adhesion Molecules Research
- Intracranial Aneurysms: Treatment and Complications
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Thyroid and Parathyroid Surgery
- Erythrocyte Function and Pathophysiology
- Animal Vocal Communication and Behavior
- Synthesis and Biological Activity
- Hernia repair and management
- Medical Imaging Techniques and Applications
- Ion Channels and Receptors
- Stochastic processes and financial applications
- Animal Genetics and Reproduction
- Traditional and Medicinal Uses of Annonaceae
- Spinal Hematomas and Complications
- Gastroesophageal reflux and treatments
- Fetal and Pediatric Neurological Disorders
- Marine Invertebrate Physiology and Ecology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vascular Anomalies and Treatments
- Developmental Biology and Gene Regulation
- Planarian Biology and Electrostimulation
- RNA Research and Splicing
Osaka University
2022-2025
Kitasato University Hospital
2023
Kindai University
2022
National Sagamihara Hospital
2022
Kyushu University
1972-2021
Tsuchiura Kyodo General Hospital
2021
Toho University
1990-2017
Toho University Ohashi Medical Center
2008-2017
Hitotsubashi University
2011
Kanazawa University
1995
A stochastic model of gene-culture coevolution, suggested by the "culture historical hypothesis" Simoons and McCracken, is presented. According to this hypothesis, adult lactose absorption, believed be an autosomal dominant trait, attained a high frequency in some human populations due positive selection pressure induced culturally determined milk use those populations. Two-dimensional Kolmogorov backward equations with appropriate boundary conditions are derived for ultimate fixation...
In the course of apoptosis, blebs eventually mature into apoptotic bodies that have immune-modulating activities. We clarified changes occur in cell membrane during and those are essential for formation bodies.
A haploid sexual two-locus model of gene-culture coevolution is examined, in which a dichotomous phenotype subject to natural selection transmitted vertically with probabilities dependent on the chosen parent's genotype and offspring's genotype. Stability conditions for genetically monomorphic corner equilibria are obtained. In specialization this general model, one locus controls transmission other reception adaptive information. The edge doubly coevolutionary fully analyzed, coevolve...
The actin cytoskeleton usually lies beneath the plasma membrane. When membrane-associated is transiently disrupted or intracellular pressure increased, membrane detaches from cortex and protrudes. Such protruded regions are called blebs. However, molecular mechanisms underlying blebbing poorly understood. This study revealed that epidermal growth factor receptor kinase substrate 8 (Eps8) ezrin important regulators of rapid reassembly for initiation retraction Live-cell imaging local...
Abstract The cytoplasm in mammalian cells is considered homogeneous. In this study, we report that the cytoplasmic fluidity regulated blebbing cells; of rapidly expanding membrane blebs more disordered than retracting blebs. increase bleb caused by a sharp rise calcium concentration. STIM-Orai1 pathway regulates rapid and restricted Conversely, activated ERM protein binds to Orai1 inhibit store-operated entry blebs, which results decreased calcium, reassembly actin cortex.
Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogens transduce chemical signals have been extensively studied, roles and regulation of physical communication between morphogen-receiver remain unclear. Here, we show that Wnt/β-catenin–morphogen gradient, patterns embryonic anterior-posterior (AP) axis, generates intercellular tension along AP axis controlling membrane cadherin levels in zebrafish embryos. This “mechano-gradient” is used for cell...
we investigated the clinical efficacy of intra-arterial administration fasudil hydrochloride for cerebral vasospasm.we reviewed 90 cases treated with between August 1998 and April 2009 vasospasm.angiographic improvement vasospasm was noted in all procedures. Eight had ischemic lesion on CT at discharge Group A, which included 39 patients who presented angiographic symptomatic vasospasm. However, 4 (50%) these eight were recovered a condition GR. No showed B, 51 without symptoms. Two (3.3%)...
<h2>Summary</h2> In vertebrates, newly emerging transformed cells are often apically extruded from epithelial layers through cell competition with surrounding normal cells. However, the underlying molecular mechanism remains elusive. Here, using phospho-SILAC screening, we show that phosphorylation of AHNAK2 is elevated in neighboring RasV12 soon after induction expression, which mediated by calcium-dependent protein kinase C. addition, transient upsurges intracellular calcium, call calcium...
We studied the recovery of rats with fulminant hepatic failure (FHF) by treating them our original hybrid artificial liver support system (HALSS). developed an module having a lobule-like structure (LLS). This consists many hollow fibers regularly arranged in close proximity and hepatocyte aggregates (organoids) induced into extra capillary space centrifugal force. The LLS can express some specific functions at high levels maintain for several months vitro. In this study, we evaluated...
Abstract CTR9 is one of five genes that form the PAF1 complex, which binds to RNA polymerase II and plays critical roles in transcriptional elongation transcription-coupled histone modifications including histones H3K4me3 H3K36me3. In this study, de novo non-synonymous variants (p.(Glu15Asp) p.(Pro25Arg)) were detected two unrelated patients with macrocephaly, motor delay, intellectual disability. A pull-down assay showed mutant proteins had stronger affinities protein than wild-type...
(±)-7-Hydroxy-6-methoxy-1-(4-methoxybenzyl)-2,8-dimethyl-1,2,3,4-tetrahydroisoquinoline has been synthesised by a conventional route. The i.r., n.m.r., and mass spectra of this material are superposable on those (–)-hemirepanduline, thus proving the structure latter.
Lasers emitting comparatively low-powered beamns, giving low incident power densities in target tissue, are being used many specialities, under the acronym LLLT, standing for Low reactive-Level Laser Therapy, The authors prcsent this study data from specialty of neurosurgery concerning clinical application a GaAlAs diode (830 mm. 60 mW. continuous wave) contact technique number pain types, effectiveness was evaluated as percentage four grades: first two (excellcnt and good) were then added...
Temozolomide (TMZ) has become a key agent in treating malignant glioma; nevertheless, its survival benefit remains dismal prognosis. Histone deacetylases are often overexpressed cancer cells, and this leads to altered expression activity of numerous proteins involved carcinogenesis. Recent evidence suggests that class I histone is higher gliomas important resistance TMZ. Levetiracetam (LEV) an antiepileptic drug inhibits deacetylases, but the therapeutic effects combination regimen...
In this paper, we estimate some volatilities and analyze each value through high frequency data under financial crisis 2008. Precisely speaking, study the asymmetric diversity of volatility fluctuation, distribution mixture hypothesis proposed by Clark[4], prediction power existence jump on process. As result, 1. We observe fluctuation. 2. Fluctuation returns is occurred not only but also other factor. 3. When forecast volatility, it useful to add implied as new exogenous variable in time...
Tracheal varices are rare but cause massive or repeated hemoptysis that can be life-threatening. Patients with Graves' disease adenomatous goiter sometimes show compressive symptoms by a diffuse large goiter. However, it is extremely to form tracheal varicose veins hemoptysis. We herein report case of from caused An 82-year-old woman was diagnosed and had been treated thiamazole for 15 years. She taken an emergency room because Bronchofiberscope revealed hemorrhage remarkable in the mucosa....