A5037169518- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Calcium signaling and nucleotide metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Natural product bioactivities and synthesis
- Cervical Cancer and HPV Research
- Microbial Metabolism and Applications
- Bone Metabolism and Diseases
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Apelin-related biomedical research
- MicroRNA in disease regulation
- Flavonoids in Medical Research
University of Edinburgh
2012-2022
Technical University of Munich
2019-2020
Centre for Inflammation Research
2012-2016
The Queen's Medical Research Institute
2015-2016
Hull York Medical School
2015
University of York
2015
Medical Research Council
2012-2014
Abstract Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid myelin. Elimination these impaired precise control retinal ganglion axon arbor size during formation and maturation retinotectal connectivity degraded functional processing visual stimuli. Therefore, fine-tune neural circuits independently their canonical role make
Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated reported in multiple human inflammatory diseases. Enhancing neutrophil has proresolution anti-inflammatory effects preclinical models inflammation. Here we investigate ability flavones apigenin, luteolin, wogonin induce vitro resolve inflammation vivo. Human was assessed morphologically flow cytometry following incubation...
Abstract Neutrophilic inflammation is tightly regulated and subsequently resolves to limit tissue damage promote repair. When the timely resolution of dysregulated, disease results. One key control mechanism neutrophil apoptosis, followed by apoptotic cell clearance phagocytes such as macrophages. Cyclin-dependent kinase (CDK) inhibitor drugs induce apoptosis in vitro rodent models. Here we present first vivo evidence, using pharmacological genetic approaches, that CDK9 involved...
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice. Much less is known about the protein composition myelin non-mammalian species. Here, we assess proteome biochemically purified from brains adult zebrafish ( Danio rerio ), considering its increasing popularity as model organism for biology. Combining gel-based and gel-free proteomic approaches, identified > 1,000...
The neurotrophic tyrosine kinase receptor type 2 (Ntrk2, also known as TrkB) and its ligands brain derived factor (Bdnf), neurotrophin-4 (NT-4/5), neurotrophin-3 (NT-3) are primarily for their multiple effects on neuronal differentiation survival. Here, we provide evidence that Ntrk2 plays a role in the pathologic remodeling of spleen accompanies chronic infection. We show Leishmania donovani-infected mice, is aberrantly expressed splenic endothelial cells new maturing blood vessels within...
High risk (oncogenic) human papillomavirus (HPV) infection causes cervical cancer. Infections are common but most clear naturally. Persistent can progress to Pre-neoplastic disease (cervical intraepithelial neoplasia/CIN) is classified by histology (CIN1-3) according severity. Cervical abnormalities screened for cytology and/or detection of high HPV both methods imperfect prediction which women need treatment. There a understand the host virus interactions that lead different outcomes and...
Abstract Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid myelin. Elimination these impaired precise control retinal ganglion axon arbor size during formation and maturation retinotectal connectivity, consequence visual acuity. Therefore, fine-tune neural circuit structure function independently their canonical role make
Summary Recent reports revealed heterogeneity of oligodendrocyte precursor cells (OPCs). It remains unclear if reflects different types with distinct functions, or rather transiently acquired states the same function. By integrating lineage formation individual OPC clones, single-cell transcriptomics, calcium imaging and manipulation neural activity, we show that OPCs in zebrafish spinal cord can be divided into two functionally entities. One subgroup forms elaborate networks processes...