A5029072814- Musculoskeletal pain and rehabilitation
- Asthma and respiratory diseases
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Birth, Development, and Health
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Cell Function and Interaction
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Placebo Effect
- Hemodynamic Monitoring and Therapy
- Pain Management and Opioid Use
- Health disparities and outcomes
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Pediatric Pain Management Techniques
- Obesity, Physical Activity, Diet
- Allergic Rhinitis and Sensitization
- Eosinophilic Esophagitis
- Health Literacy and Information Accessibility
- IL-33, ST2, and ILC Pathways
- Health Systems, Economic Evaluations, Quality of Life
- Mobile Health and mHealth Applications
- Innovations in Medical Education
- Pain Mechanisms and Treatments
- Inhalation and Respiratory Drug Delivery
Peter MacCallum Cancer Centre
2025
Accreditation Council for Graduate Medical Education
2023
Cork University Hospital
1997-2023
Central Queensland University
2023
Tallaght University Hospital
2010-2022
Trinity College Dublin
2004-2022
University College London
1990-2016
Pfizer (Ireland)
2015
Boston Children's Hospital
2010-2011
St. James's Hospital
2004-2007
The transversus abdominis plane (TAP) block is a novel approach for blocking the abdominal wall neural afferents via bilateral lumbar triangles of Petit. We evaluated its analgesic efficacy in patients during first 24 postoperative hours after surgery, randomized, controlled, double-blind clinical trial.Thirty-two adults undergoing large bowel resection midline incision were randomized to receive standard care, including patient-controlled morphine analgesia and regular nonsteroidal...
The abdominal wall is a significant source of pain after surgery. Anterior analgesia may assist in improving postoperative analgesia. We have recently described novel approach to block the neural afferents via bilateral lumbar triangles Petit, which we termed transversus abdominis plane block. clinical efficacy has been demonstrated randomized controlled trial adults undergoing surgery.After institutional review board approval, anatomic studies were conducted determine deposition and spread...
<h3>OBJECTIVES</h3> To assess relations between the adiposity of children and their parents to establish whether tracking from childhood adulthood varies according parental body mass index (BMI). <h3>METHODS</h3> Longitudinal data 1958 British birth cohort study were used (6540 men 6207 women). The height weight subjects measured at 7, 11, 16, 23 (self reported), 33 years. Parental self reported when 11 years old. classified into six BMI (weight/height<sup>2</sup>) groups. <h3>RESULTS</h3>...
cDNA clones encoding CD31 have been isolated by transient expression. The sequence of expressed on human umbilical vein endothelial cells (HUVEC) is identical to that the monocyte-like cell line HL60. In HUVEC. concentrated in regions cell-cell contacts. a member Ig superfamily and most closely related carcinoembryonic antigen CEA, consisting four contiguous C2 domains. localization contacts, similarity known intercellular adhesion molecule (ICAM), strongly suggest may function as an ICAM,...
Cancer pain is a prevalent and debilitating symptom that impacts quality of life. Pain management remains challenging; however, due to various barriers, including stigma associated with opioid use, ambiguous roles clinicians, diverse attitudes toward among healthcare professionals, patients, carers. To explore the surrounding cancer carers, health professionals at tertiary hospital. A cross-sectional online survey was conducted Peter MacCallum Centre. The included demographic measures...
<h3>Abstract</h3> <b>Objective</b>: To investigate the relation between birth weight and socioeconomic disadvantage during childhood adolescence in a cohort study. <b>Design</b>: Longitudinal analysis of to social class, household amenities overcrowding, financial difficulties as reported by parents at interview when participants were aged 7, 11, 16 years; receipt unemployment or supplementary benefits age 23. <b>Subjects</b>: Male 1958 (national child development study) born resident Great...
Because of difficulties encountered with patient compliance using the standard visual analogue scale, a new nonvisual scale has been devised for pain measurement. The was found to give values that correlated well given and be more easily understood. considered simpler reliable than heretofore in use.
Background We aimed to elucidate early antecedents of suicide including possible mediation by child development. Method Using the 1958 birth cohort, based on British births in March 1958, individuals were followed up adulthood. used data collected at and age 7 years from various informants. Suicides occurring 31 May 2009 identified linked national death certificates. Multivariable Cox proportional hazard models investigate risk factors. Results Altogether 12399 participants ( n = 44...
Background It has been suggested that early life exposures are important determinants of geographical variations in adult diseases. We examined inter-regional migrants Britain to evaluate the relative importance and recent for cardiorespiratory risk factors, mental ill-health sensory function. Methods A total 9023 persons born throughout England, Scotland Wales during 1 week 1958 were followed periodically through childhood into adulthood. At 44–45 years, height, body mass index (BMI), blood...
Six patients with asthma (American Thoracic Society (ATS) criteria), maintained on inhaled beta 2-agonists alone, were treated corticosteroid (budesonide 400 micrograms b.d.) for a period of three months. Prior to steroid therapy, baseline spirometry, bronchodilator response and bronchial hyperresponsiveness documented endobronchial biopsies obtained immunopathological analysis. Frozen sections the investigated using immunoperoxidase methods, panel monoclonal antibodies selected reveal...
Palliation of inoperable esophageal cancer with covered stents aims to relieve progressive dysphagia and improve health-related quality life (HRQoL). Introducing a stent across the esophagogastric junction in lower third tumors may predispose unchecked gastro-esophageal reflux (GER). Esophageal incorporating an anti-reflux valve have been introduced address this problem. We prospectively compared standard palliation tumors. Forty-nine consecutive patients malignant were randomized receive (n...
Physiological and Immunopathological parameters were investigated in 15 patients with diagnosed asthma, 6 non-asthmatics presenting other chest symptoms. The symptom-free asthmatics expressed bronchohyperresponsiveness a mean provocative dose producing 20% fall forced expiratory volume one second (PD20FEV1) of 1 mg histamine. None the responded to 16 Twenty four hours later bronchoscopy was performed endobronchial biopsies obtained. Histological staining frozen biopsy sections revealed...
A nonrandomized controlled trial.This study aims to explore the effectiveness of group-based stratified care in primary care.Stratified based on psychosocial screening (STarT Back) has demonstrated greater clinical and cost-effectiveness patients with low back pain. However, pain interventions are often delivered groups evaluating this system a group setting is important.Patients were recruited from 60 general practices linked physiotherapy services. new intervention was compared historical...
BACKGROUND--Nearly all asthmatic subjects show bronchial hyperresponsiveness, in that the provocative concentration of histamine reducing forced expiratory volume one second (FEV1) by 20% (PC20FEV1) is < or = 8 mg/ml histamine, and have underlying chronic inflammation wall mediated T cells. The possible cause effect relationship between these phenomena remains an enigma. As a proportion clinically healthy this study was undertaken to determine whether they also evidence inflammation....
Abstract Objective The aim was to examine the relationship between gestational age and birthweight adult chronic widespread pain ( CWP ). Design participants A prospective cohort study of 18,558 recorded gestation at birth. Exposure Participants were categorised by (fullterm ≥37 weeks; preterm <37 week) (full FBW ) ≥2.5 kg; low LBW 1.5–2.5 very VLBW <1.5 kg). Outcome presence or absence measured self‐completed questionnaire in 8572 45 yrs. Risk ratios calculated using Poisson...