A5028869620- Neuroscience and Neuropharmacology Research
- Synthesis and Biological Evaluation
- Receptor Mechanisms and Signaling
- Molecular Sensors and Ion Detection
- Nicotinic Acetylcholine Receptors Study
Jagiellonian University
2022-2023
Kainate receptors belong to the family of glutamate ion channels, which are responsible for majority rapid excitatory synaptic transmission in central nervous system. The therapeutic potential kainate is still poorly understood, also due lack potent and subunit-selective pharmacological tools. In search selective ligands GluK3 receptor subtype, a series quinoxaline-2,3-dione analogues was synthesized pharmacologically characterized at selected recombinant ionotropic receptors. Among them,...
Kainate receptors are a class of ionotropic glutamate that respond to the excitatory neurotransmitter in central nervous system and play an important role development neurodegenerative disorders regulation synaptic function. In current study, we investigated structure- activity relationship series quinoxaline-2,3-diones substituted at N1, 6, 7 positions, as ligands kainate homomeric GluK1-3 GluK5. Pharmacological characterization showed all derivatives obtained exhibited micromolar affinity...