About
Contact & Profiles
A5093252331
Research Areas
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
Howard Hughes Medical Institute
2023
Brandeis University
2023
AlphaFold2 (ref. 1) has revolutionized structural biology by accurately predicting single structures of proteins. However, a protein's biological function often depends on multiple conformational substates2, and disease-causing point mutations cause population changes within these substates3,4. We demonstrate that clustering multiple-sequence alignment sequence similarity enables to sample alternative states known metamorphic proteins with high confidence. Using this method, named...
10.1038/s41586-023-06832-9
article
EN
cc-by
Nature
2023-11-13
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