A5011515974- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- Prostate Cancer Treatment and Research
- Histiocytic Disorders and Treatments
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Aquatic Ecosystems and Phytoplankton Dynamics
- Tumors and Oncological Cases
- Marriage and Sexual Relationships
- Ferroptosis and cancer prognosis
- Mitochondrial Function and Pathology
- Genital Health and Disease
- Autophagy in Disease and Therapy
- Parvovirus B19 Infection Studies
- Cancer-related molecular mechanisms research
Hainan General Hospital
2020-2024
Hainan Medical University
2020-2024
Haikou City People's Hospital
2017
ABSTRACT Objective High glucose damages rat Schwann cells (SCs), which is closely related to the dysfunction of mitochondria‐associated endoplasmic reticulum membranes (MAMs). Therefore, present study aimed investigate protective effects and mechanisms modified bone marrow mesenchymal stem (BMSCs) mitochondrial fusion protein 2 (Mfn2) BMSCs against SCs injury. Methods The Mfn2‐modified were constructed after culturing with neural‐induced differentiation solution. MAP‐2...
Genetic factors play an indispensable role in the pathogenesis of lifelong premature ejaculation (LPE). The susceptibility genes/SNPs that have been discovered are very limited and can only explain part genetic effects LPE. Therefore, discovering more polymorphisms associated with occurrence development LPE will help reveal LPE.We conducted a genome-wide association study 486 Chinese male Han people (cases controls). We used Gene Titan multi-channel instrument Axiom Analysis Suite 6.0...
Rosai-Dorfman disease (RDD) is a rare histiocytic disorder of unclear etiology, which commonly presented with the enlargement lymph nodes neck and head. Here, we report an unusual case 77-year-old male patient presenting left kidney lesion several small enlarged nod es around abdominal aorta. The diagnosis cancer was suspected underwent laparoscopic exploration node biopsy. Only saponification renal surrounding fat pedicle 5 aortic were found; no found. Surrenalectomy lymphadenectomy...
The purpose of this study was to investigate whether the polymorphisms SLC6A4 gene affect occurrence lifelong premature ejaculation (LPE). In case-control study, Agena MassARRAY used genotype 91 LPE patients and 362 controls. Then, genetic model haplotype analysis were utilised explore correlation between risk. results showed that allele T, T/T C/T-T/T rs9303628 significantly correlated with a decreased risk in (p = .009), co-dominant .025) dominant .014) respectively. Allele T rs2054847...
The study of Bone marrow mesenchymal stem cells (BMSCs)-based treatment is still unmet needs topic in recent years, especially focusing on the therapeutic effects genetically modified BMSCs. IFN- β acts as a critical mediator occurrence and progress prostate cancer. Additionally, its related signal transduction pathways affect malignancies. This aims to discussion mechanism -modified BMSCs impeding metastatic tropism A total 40 male mice (SPF) with clean grade were randomized into 4 groups...
Abstract Background Lifelong premature ejaculation (LPE) is one of the most common ejaculatory dysfunctions in men. The serotonin (5-HT) synthesis rate-limiting enzyme ( TPH2 ) and receptor HTR1A 5-HT regulatory system may play a key role pathogenesis LPE. However, there are few studies on effects polymorphisms LPE risk. We speculated that affect occurrence development Chinese Han population. Methods In this study, 91 patients with 362 normal controls aged 18 to 64 years were enrolled male...
To investigate the effect of high glucose on mitochondrial-related ER membranes (MAMs) in rat Schwann cells (SCs) and mechanism cell injury. SCs (RSC96) were used as control group, RSC96 cultured a environment for 48 h set experimental group. The level intracellular calcium was observed by flow cytometry, ROS levels detected DCFH-DA fluorescent probe. subcellular structure transmission electron microscopy, focusing morphology mitochondria endoplasmic reticulum well formation MAMs. expression...
Prostate cancer (PCa) is a malignant tumor in males, with majority of the cases advancing to metastatic castration resistance. Metastasis leading cause mortality PCa. The traditional early detection and prediction approaches cannot differentiate between different stages Therefore, new biomarkers are necessary for clear differentiation PCa provide precise therapeutic intervention.The objective study was find significant differences genes combine three GEO datasets TCGA-PRAD (DEG). Weighted...