A5029284801- Glioma Diagnosis and Treatment
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
University of Freiburg
2022-2024
University Medical Center Freiburg
2022-2024
Cancer Research UK Scotland Institute
2020-2023
University of Glasgow
2020-2023
Metropolitan University
2022
Cancer Research UK
2020-2022
Betsi Cadwaladr University Health Board
2020
Ludwig-Maximilians-Universität München
2018
Universitätsklinikum Würzburg
2018
Abstract Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to lack of effective treatment options leading persistence or recurrence. We investigated therapeutic potential targeting anti-apoptotic BCL-2 proteins GBM. Levels BCL-xL and MCL-1 were consistently increased compared with non-malignant cells tissue. Moreover, we found that relative their differentiated counterparts, patient-derived stem-like also...
Abstract Despite extensive research, little progress has been made in glioblastoma therapy, owing part to a lack of adequate preclinical vivo models study this disease. To mitigate this, primary patient-derived cell lines, which maintain their specific stem-like phenotypes, have replaced established lines. However, due heterogenous tumour growth inherent glioblastoma, the use cells for orthotopic studies often requires large experimental group sizes. Therefore, when using intracranial...
Tumor cells infiltrating the brain are a typical hallmark of glioblastoma. Invasiveness glioma has been associated with ETS proto-oncogene 1 (ETS-1). In non-glial tumors, ETS-1 expression linked to hypoxia. However, it is not known whether hypoxia regulates in glioblastoma.The spatial distribution primary glioblastoma was assessed using immunohistochemistry. glioblastoma-derived mesenchymal stem-like (gbMSLCs) determined immunocytochemistry. The effect on gbMSLCs, cell lines and endothelial...
Abstract IDH wild-type glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to lack of effective treatment options leading persistence or recurrence. Tackling this, we investigated therapeutic potential targeting anti-apoptotic BCL-2 proteins GBM. Levels anti- apoptotic BCL-xL and MCL-1 were consistently increased compared with non- cells tissue. Moreover, found that relative their differentiated counterparts,...
Abstract Background Infiltration of glioblastoma (GBM) throughout the brain leads to its inevitable recurrence following standard-of-care treatments, such as surgical resection, chemo-, and radiotherapy. A deeper understanding mechanisms invoked by GBM infiltrate is needed develop approaches contain disease reduce recurrence. The aim this study was discover through which extracellular vesicles (EVs) released influence microenvironment facilitate infiltration, determine how altered matrix...
SUMMARY Background Infiltration of glioblastoma (GBM) throughout the brain leads to its inevitable recurrence following standard-of-care treatments, such as surgical resection, chemo- and radio-therapy. A deeper understanding mechanisms invoked by GMB infiltrate is needed develop approaches contain disease reduce recurrence. The aim this study was discover through which extracellular vesicles (EVs) released GBM influence microenvironment facilitate infiltration, determine how altered matrix...
Abstract Despite extensive research, little progress has been made in glioblastoma therapy, owing part to a lack of adequate preclinical vivo models study this disease. To mitigate this, primary patient-derived cell lines, which maintain their specific stem-like phenotypes, have replaced established lines. However, due heterogenous tumour growth inherent glioblastoma, the use cells for orthotopic studies often requires large experimental group sizes. Therefore, when using intracranial...