- Phytochemicals and Antioxidant Activities
- Ginger and Zingiberaceae research
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Medicinal Plant Research
- Phytochemistry and Biological Activities
- Phytoestrogen effects and research
- Diet, Metabolism, and Disease
- Botanical Research and Applications
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- GABA and Rice Research
- Medicinal Plants and Neuroprotection
- Natural Compound Pharmacology Studies
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Mangiferin and Mango Extracts
- Piperaceae Chemical and Biological Studies
- Phytochemistry and biological activity of medicinal plants
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Insect Pest Control Strategies
- Fatty Acid Research and Health
- Bioactive Compounds and Antitumor Agents
- Dental Implant Techniques and Outcomes
National Research and Innovation Agency
2024
National Nuclear Energy Agency of Indonesia
2024
Universiti Putra Malaysia
2010-2019
Tun Hussein Onn University of Malaysia
2017-2019
Universiti Teknologi MARA System
2017
Al-Quds University
2015
Faculty of Public Health
2015
National University of Malaysia
1993-2012
Taylor's University
2012
Malaysian Nuclear Agency
2008
Obesity is the accumulation of abnormal or excessive fat that may interfere with maintenance an optimal state health. The excess macronutrients in adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, reduces production adiponectin, predisposing a pro-inflammatory oxidative stress. increased level 6 liver synthesize secrete C-reactive protein. As risk factor, inflammation imbedded mechanism developed cardiovascular diseases...
In the recent years, health benefits of pigmented rice varieties have reported due to presence bioactive compounds. this study, phytochemical constituents (total phenolic, flavonoid and anthocyanin content) individual phenolics flavonoids extracts sixteen genotypes bran were evaluated using spectrophotometric ultra-high performance liquid chromatography method. Antioxidative properties free bound fractions nitric oxide 1,1-diphenyl-2-picrylhydrazyl scavenging assays. Extracts for...
Obesity is well associated as being an interfering factor in metabolic diseases such hypertension and diabetes by increasing the secretion of proinflammatory markers from adipose tissue. Having healthy effects, vitamin C could work anti-inflammatory agent through its antioxidant capacity.FPSK_Mac [13]04.The aim study reported here was to identify effect on reducing levels inflammatory hypertensive and/or diabetic obese adults.Sixty-four patients, who were had high markers, primary health...
Nowadays, phytochemicals and antioxidants in plants are raising interest consumers for their roles the maintenance of human health. Phenolics flavonoids known health-promoting properties due to protective effects against cardiovascular disease, cancers other disease. Ginger (Zingiber officinale) is one traditional folk medicinal it widely used cooking Malaysia. In this study, four levels glasshouse light intensities (310, 460, 630 790 μmol m(-2)s(-1)) were order consider effect intensity on...
A split plot 3 by 4 experiment was designed to examine the impact of 15-week variable levels nitrogen fertilization (0, 90, 180 and 270 kg N/ha) on characteristics total flavonoids (TF), phenolics (TP), non structurable carbohydrate (TNC), net assimilation rate, leaf chlorophyll content, carbon ratio (C/N), phenyl alanine lyase activity (PAL) protein their relationships, in three varieties Labisia pumila Blume (alata, lanceolata). The treatment effects were solely contributed application;...
Almost all countries are facing obesity endemic, although great variation exists between and within countries.Sedentary lifestyle high fat (high caloric) diet have increased globally as a result of industrial, urban mechanic changes developing countries.Improved economic status promotes the metabolic syndrome in age groups particularly young adults.Developing counties became desperate need for establishing new polices strategies regulated managed programs; order to encounter factors highly...
A factorial split plot 4 × 3 experiment was designed to examine and characterize the relationship among production of secondary metabolites (total phenolics, TP; total flavonoids, TF), carbohydrate content photosynthesis three varieties Malaysian medicinal herb Labisia pumila Benth. namely alata, lanceolata under CO2 enrichment (1,200 µmol mol-1) combined with four levels nitrogen fertilization (0, 90, 180 270 kg N ha-1). No varietal differences were observed, however, as increased from 0...
The extractive capability of phenolic components from herb material is considerably depended on the type solvent. In our research three kinds solvents (methanol, acetone and chloroform) extracts different parts (leaves, stems rhizomes) two Malaysian young ginger varieties (Halia Bara Halia Bentong) were used to examine effects extraction solvent total phenolics (TP), flavonoids (TF), quercetin, catechin rutin content antioxidant activity [1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay]. Results...
Zingiber officinale Roscoe. (Family Zingiberaceae) is well known in Asia. The plant widely cultivated village gardens the tropics for its medicinal properties and as a marketable spice Malaysia. Ginger varieties are rich physiologically active phenolics flavonoids with range of pharmacological activities. Experiments were conducted to determine feasibility increasing levels (quercetin, rutin, catechin, epicatechin, kaempferol, naringenin, fisetin morin) phenolic acid (gallic acid, vanillic...
Etlingera elatior is a well-known herb in Malaysia with various pharmaceutical properties. E. flowers grown three different locations of (Kelantan, Pahang and Johor), were investigated for differences their content secondary metabolites (total phenolics [TPC], total flavonoids [TFC], tannin [TTC]) as well antioxidant, anticancer, antibacterial Phenolic acids isolated identified using ultra-high performance liquid chromatography (UHPLC). Ferric reducing antioxidant potential (FRAP)...
The aim of this study was to examine the effects extraction methods on antioxidant capacities red dragon fruit peel and flesh. Antioxidant were measured using ethylenebenzothiozoline-6-sulfonic acid (ABTS) radical cation assay ferric reducing power (FRAP). Total phenolic content (TPC) determined Folin-Ciocalteu reagent while quantitative determination total flavonoid (TFC) conducted aluminium trichloride colorimetric method. Betacyanin (BC) by spectrophotometer. Red extracted conventional...
Sweet basil (Ocimum basilicum Linnaeus) is aromatic herb that has been utilized in traditional medicine. To improve the phytochemical constituents and pharmaceutical quality of sweet leaves, ultraviolet (UV)-B irradiation at different intensities (2.30, 3.60, 4.80 W/m²) durations (4, 6, 8, 10-h) was applied post-harvest stage. Total flavonoid content (TFC) total phenolic (TPC) were measured using spectrophotometric method, individual flavonoids acids identified ultra-high performance liquid...
Type 2 diabetes mellitus (T2DM) is associated with hyperglycemia, inflammatory disorders and abnormal lipid profiles. Several functional foods have therapeutic potential to treat chronic diseases including diabetes. The of pomegranate has been stated by multitudinous scientists. present study aimed evaluate the effects juice seed powder on levels plasma glucose insulin, biomarkers, profiles, health pancreatic islets Langerhans in streptozotocin (STZ)-nicotinamide (NAD) induced T2DM Sprague...
Eurycomanone is a cytotoxic compound found in Eurycoma longifolia Jack. Previous studies had noted the effect against various cancer cell lines. The aim of this study to investigate cytotoxicity human hepato carcinoma vitro and mode action. eurycomanone was evaluated using MTT assay death detected by Hoechst 33258 nuclear staining flow cytometry with Annexin-V/propidium iodide double staining. protein expression Bax, Bcl-2, p53 cytochrome C were studied spesific antibody conjugated...
The relationship between phenolics and flavonoids synthesis/accumulation photosynthesis rate was investigated for two Malaysian ginger (Zingiber officinale) varieties grown under four levels of glasshouse light intensity, namely 310, 460, 630 790 μmol m−2s−1. High performance liquid chromatography (HPLC) employed to identify quantify the polyphenolic components. results HPLC analysis indicated that synthesis partitioning quercetin, rutin, catechin, epicatechin naringenin were high in plants...
A split plot 3 by 4 experiment was designed to characterize the relationship between production of gluthatione (GSH), oxidized (GSSG), total flavonoid, anthocyanin, ascorbic acid and antioxidant activities (FRAP DPPH) in three varieties Labisia pumila Blume, namely alata, lanceolata, under four levels nitrogen fertilization (0, 90, 180 270 kg N/ha) for 15 weeks. The treatment effects were solely contributed application; there neither varietal nor interaction observed. As decreased from 0...
Oxidative stress attributes a crucial role in chronic complication of diabetes. The aim this study was to determine the most effective part pomegranate on oxidative markers and antioxidant enzyme activities against streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats. Male Sprague-Dawley rats were randomly divided into six groups. Experimental diabetes induced by single intraperitoneal injection (i.p), 15 min after i.p administration NA. Diabetic showed significant increase plasma...
In the present study, two accessions of Centella asiatica (CA03 and CA23) were subjected to gamma radiation examine response these in terms survival rate, flavonoid contents, leaf gas exchange mass. Radiation Sensitivity Tests revealed that based on LD(50) (gamma doses killed 50% plantlets) plantlets achieved at 60 Gy for CA03 40 CA23. The nodal segments irradiated with rays does 30 accession 'CA03' 20 'CA23. segment was evaluated by recording content, biomass. experiment designed as RCBD...