A5015628005- Nanoparticle-Based Drug Delivery
- Herpesvirus Infections and Treatments
- Nanocluster Synthesis and Applications
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Electrospun Nanofibers in Biomedical Applications
- Molecular Biology Techniques and Applications
- BRCA gene mutations in cancer
- SARS-CoV-2 detection and testing
- Ginger and Zingiberaceae research
- Gold and Silver Nanoparticles Synthesis and Applications
- Pleural and Pulmonary Diseases
- Lanthanide and Transition Metal Complexes
- Microbial Inactivation Methods
- T-cell and Retrovirus Studies
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biosensors and Analytical Detection
- HIV/AIDS oral health manifestations
University of Louisville
2011-2025
University of Louisville Hospital
2022
James Graham Brown Foundation
2017
A lung abscess is defined as a necrotizing infection with pus-filled cavity. The can be primary in previously normal or secondary to pre-existing condition such bronchial obstruction immunosuppression by HIV steroid use. Abscesses are more common men aged 54-74 years, history of smoking, alcohol other sedative use, and immunodeficiency. We present case 65-year-old male past medical chronic obstructive pulmonary disease (COPD) who presented two months following pneumonia was diagnosed an...
Despite current prophylactic strategies, sexually transmitted infections (STIs) remain significant contributors to global health challenges, spurring the development of new multipurpose delivery technologies protect individuals from and treat virus infections. However, there are few methods currently available prevent no method date that cures human immunodeficiency (HIV) infection or combinations STIs. While oral topical preexposure prophylaxes have protected against HIV infection, they...
Gold nanoparticles (GNPs) have tremendous potential as cancer-targeted contrast agents for diagnostic imaging. The ability to modify the particle surface with both disease-targeting molecules (such cancer-specific aptamer AS1411) and gadolinium chelate Gd(III)-DO3A-SH) enables tailoring particles specific cancer-imaging diagnosis. While amount of image generated by nanoparticle is often low, it can be augmented assistance computer analysis algorithms. In this work, gold...
Ubiquilin (UBQLN) proteins are adaptors thought to link ubiquitinated the proteasome. However, our lab has recently reported a previously unappreciated role for loss of UBQLN in lung cancer progression. In fact, genes lost over 50% samples examined. reason not been proposed, nor selective pressure that could lead deletion reported. Diesel Exhaust Particles (DEP) major concern large cities developing nations and DEP exposed populations at an increased risk number illnesses, including cancer....
Magnetic resonance imaging (MRI) is mostly used for cancer diagnosis due to its excellent contrast resolution. However, using MRI somewhat limited by sensitivity. In this study, we assessed the ability of theranostic platform consisting gold nanoparticles functionalized with a targeting aptamer; AS1411 and gadolinium chelate (Dotarem thiol derivative; Gd (III)-DO3A) as agent target malignant tumors enhancing detected tumor. The proposed technology novel injectable detection monitoring...
During the COVID-19 pandemic, laboratories experienced periods of shortages for certain critical materials required to meet high demand SARS-CoV-2 testing. The U.S. Food & Drug Administration provided a template molecular diagnostic testing, including guidance specimen pooling process in order evaluate performance nucleic acid amplification assay. This study aimed testing pooled specimens consisting four nasopharyngeal swab using Luminex ARIES® platform. Results indicated that there was loss...