A5003345946- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Eicosanoids and Hypertension Pharmacology
- Receptor Mechanisms and Signaling
- Osteoarthritis Treatment and Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Interpreting and Communication in Healthcare
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Workaholism, burnout, and well-being
- Electrospun Nanofibers in Biomedical Applications
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Primary Care and Health Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Advanced Drug Delivery Systems
- Dental Health and Care Utilization
- Spinal Cord Injury Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Extracellular vesicles in disease
- Myofascial pain diagnosis and treatment
University of North Carolina at Chapel Hill
2014-2023
University of Utah
2023
Duke University
2016
Christie's
2014
Decreased activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, contributes to pain in humans and animals. Previously, we demonstrated development COMT-dependent is mediated by both β2- β3-adrenergic receptors (β2ARs β3ARs). Here investigated molecules downstream β3ARs driving animals with decreased COMT activity. Based on evidence linking their role synthesis β3AR stimulation, hypothesized nitric oxide (NO) proinflammatory cytokines drive pain. To test...
Abstract Background Patients with chronic pain disorders exhibit increased levels of catecholamines alongside diminished activity catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. The authors found acute pharmacologic inhibition COMT in rodents produces hypersensitivity to mechanical and thermal stimuli via β-adrenergic receptor (βAR) activation. contribution distinct βAR populations the development persistent linked abnormalities catecholamine signaling...
The Prenatal Oral Health Program (pOHP) was developed to educate dental students on prenatal oral health and promote access care for pregnant women. advancement has occurred in support of quality improvement. This mixed-methods design combined quantitative data from fourth-year who participated the pOHP (N = 81) qualitative a student-faculty-staff focus group discussion 7). Different clinical structures, appropriate leveling curriculum, management with patient coordinator, inclusion...