A5073497254- Traditional and Medicinal Uses of Annonaceae
- Seaweed-derived Bioactive Compounds
- Malaria Research and Control
- Education during COVID-19 pandemic
- Polysaccharides and Plant Cell Walls
- Phytochemical compounds biological activities
- Education and Digital Technologies
- Galectins and Cancer Biology
- Science and Education Research
- Invertebrate Immune Response Mechanisms
- COVID-19 and Mental Health
- Glycosylation and Glycoproteins Research
- Marine and coastal plant biology
- Phytochemistry and Bioactivity Studies
- Algal biology and biofuel production
- Fungal Biology and Applications
- Research on Leishmaniasis Studies
- Cocoa and Sweet Potato Agronomy
- Educational Innovations and Technology
- Microbial Metabolites in Food Biotechnology
- Synthesis and bioactivity of alkaloids
- Cancer therapeutics and mechanisms
- Toxin Mechanisms and Immunotoxins
Universidade Federal do Ceará
2002-2023
Universidade do Estado do Amazonas
2013-2023
Escola Superior de Ciências da Saúde
2015
National Institute of Amazonian Research
2008-2012
The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. Artemisia annua, respectively). synthetic quinoline (e.g. chloroquine) semi-synthetic derivatives artesunate) developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum vivax drug-resistance of concern. There an urgent need for new anti-malarials. Traditionally Amazonian may provide treatments drug-resistant P. falciparum. Herein, in vitro...
Indole alkaloids ellipticine (1), cryptolepine triflate (2a), rationally designed 11-(4-piperidinamino)cryptolepine hydrogen dichloride (2b) and olivacine (3) (an isomer of 1) were evaluated in vitro against Plasmodium falciparum vivo berghei-infected mice. 1-3 inhibited P. (IC₅₀≤1.4 μM, order activity: 2b>1>2a>3). In toxicity to murine macrophages was revealed selectivity indices (SI) 10-12 for 2a SI>2.8×10² 1, 2b 3. 1 administered orally at 50mg/kg/day highly active berghei (in inhibition...
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Picrolemma sprucei Hook. f. (Simaroubaceae) is a medicinal plant that used throughout the Amazon region in treatment of malaria. No previous report has been published on biological activity or chemical composition fruit this species. In present study, antimalarial effects from P. was evaluated. Furthermore, rapid and simple thin-layer chromatography-photodensitometry (TLC-PD) analytical method utilized for semi-quantitative determination quassinoids isobrucein B (1) neosergeolide (2) fruit....
During the COVID-19 pandemic, a global shift to remote education has occurred. This study investigated impact of teaching on health students at public university in Amazonas, Brazil. The participants were Nursing, Medicine and Dentistry courses, submitted completely learning. Data collection was carried out online, followed by statistical analysis. In total, 175 participated, representing 17.6% from 20.6% 19.7% Dentistry. Most female (68.0%) entered through capital's admission system...
A utilização de metodologias ativas vem trazendo benefícios reais para o processo ensino-aprendizagem, e isso pode ser bem visível as disciplinas consideradas grande complexidade, a exemplo da Bioquímica. Alinhando preocupação entre despertar interesse dos alunos na disciplina melhorar aprendizagem uma forma interativa surge crescente jogos didáticos. O presente trabalho tem como objetivo apresentar jogo Perfil Bioquímica, que teve sua inspiração no comercial Júnior 2 Grow Jogos Brinquedos...