The objective of this investigation was to evaluate the influence micro- and nanoplastic particles composed polyethylene terephthalate (PET), a significant contributor plastic pollution, on human brain vascular pericytes. Specifically, we delved into their impact mitochondrial functionality, oxidative stress, expression genes associated with ferroptosis functions. Our findings demonstrate that exposure monoculture pericytes PET in vitro at concentration 50 μg/ml for duration 3, 6 10 days did...

Experimental studies on the folding and unfolding of large multi-domain proteins are challenging, given proteins' complex energy landscapes with multiple intermediates. Here, we report a mechanical study 346-residue, two-domain leucine binding protein (LBP) from bacterial periplasm. Forced LBP is prerequisite for its translocation across cytoplasmic membrane into During stretching LBP, observe that 38% flux followed two-state pathway, giving rise to single force peak at ~70 pN an contour...

Ochratoxin A (OTA) is a common mycotoxin and known contaminant of crops, foods drinks. As OTA crosses the blood-brain barrier, this study investigated role OTA, as an environmental hazard, on neuronal survival viability. The impact range concentrations expression MAPT, BAX, P53, BDNF TPPP genes was using human neuroblastoma (SH-SY5Y) cells. absence altered gene determined reverse transcription quantitative PCR demonstrated that exposure to typical daily dose delivered brain (2 fM), may not...

Unconscious and unplanned radiation exposures are a severe threat to gonads particularly ovaries. The present study aims at finding radioprotective effect of Tinospora cordifolia (Willd.) Miers root extract (TCRE) in Swiss albino mice were divided into four groups: Group 1 served as “normal” is administered double distilled water 2 given TCRE with optimum dosage selected 75 mg/mice. 3 serving the purpose “irradiated control” exposed 2.5 Gy gamma radiation. 4 (experimental) prior exposure...

The eyes play a crucial role in vision and emotional expression, their loss can profoundly affect appearance psychological well-being. Eye may result from trauma, tumors, infections, malignancies, or congenital abnormalities. Surgical methods for removing an eye include enucleation, evisceration, exenteration. When surgical reconstruction is insufficient, prosthetic rehabilitation becomes necessary, requiring collaboration among ophthalmologists, oral maxillofacial surgeons, prosthodontists....

Abstract The objective of this investigation was to evaluate the influence micro- and nanoplastic particles composed polyethylene terephthalate (PET), a significant contributor plastic pollution, on human brain vascular pericytes. Specifically, we delved into their impact mitochondrial functionality, oxidative stress, expression genes associated with stress ferroptosis. Our findings demonstrate that exposure monoculture pericytes PET in vitro at concentration 50 ppm for duration 6 days did...

In today's unconventional world, the amount of user-generated content, such as articles, books, blogs, etc., is increasing exponentially. Some might find them offensive. As well known, RNN and LSTM take a long time to analyze input since words are processed one at time; however, this happens all once in BERT. paper, suggested model uses BERT with CNN layers. These layers help improve its accuracy further. Hate Speech Offensive Language dataset used. there were three categories hate,...

Aim: The aim of the study was to scrutinize prevalence oral manifestations encountered among geriatric patients that got coronavirus disease 2019 (COVID-19) infection during pandemic and also were partially or fully vaccinated. Settings Design: This a clinical survey. Materials Methods: A questionnaire prepared which consisted patient’s generic details, personal history, previous medical drug relevant details about COVID-19 vaccination are needed record. questions designed in such manner so...

Mandible is the most common site for intraoral tumors which often requires resection of large portions mandible depending upon location and extent tumor leading to various complications such as deviation toward resected side facial disfigurement. Early prosthodontic intervention during healing period helps in training muscles establish an acceptable occlusal relation using guide flange prosthesis (GFP). This article aims describe case reports early management two patients who underwent...

Abstract Aim: The study aimed to evaluate and compare the dimensional stability, accuracy, reproducibility of two commercially available interocclusal recording materials. Settings Design: This was an in vitro study. Materials Methods: Two materials were taken—polyvinyl siloxane bis-acrylic. groups each 40 specimens made, a stainless-steel master die prepared according American dental association specification no. 19. consisted cylindrical ruled block with diameter 38 mm, height 31 mold,...

Anophthalmia leads to both physical and social disability which affects the quality day-to-day functioning of an individual. This article tends describe rehabilitation unilateral anophthalmia by a custom-made eye prosthesis. Stock-made prosthesis once served as boon prosthodontists, but with recent advances in field technology, is preferred more they cater demand patient socially acceptable manner. Iris positioning has been major challenge prosthodontists since beginning, advent modern-day...

Residual ridge resorption is a very common phenomenon observed in edentulous patients over certain span of edentulism. Though it occurs more rapidly mandibular arch than maxillary arch, severely resorbed ridges with increased inter-ridge distance often lead to difficulty prosthetic rehabilitation. This case report describes an easy yet accurate method for fabrication hollow complete denture using super-absorbent polymer as spacer the cavity single flask technique.

Residual ridge resorption is the reduction in size of bony under mucoperiosteum. The occurs faster mandibular arch as compared to maxillary arch. Fabrication any dental prosthesis over a compromised residual alveolar really challenge for prosthodontists. pattern bone observed Atwood's Orders V and VI causes difficulty providing successful dentures, especially lower denture where stability may get compromised. This clinical case report elicits combination different impression techniques...