A5059729439- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Additive Manufacturing and 3D Printing Technologies
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Surgical Sutures and Adhesives
- Calcium Carbonate Crystallization and Inhibition
- Silk-based biomaterials and applications
- Dermatologic Treatments and Research
- Hemostasis and retained surgical items
- MicroRNA in disease regulation
- Abdominal Surgery and Complications
- Cellular and Composite Structures
- Facial Rejuvenation and Surgery Techniques
- Hernia repair and management
- Cancer Research and Treatment
- Hair Growth and Disorders
- Cancer-related molecular mechanisms research
- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Reconstructive Facial Surgery Techniques
Union Hospital
2019-2025
Huazhong University of Science and Technology
2019-2025
Cornell University
2020
Case Western Reserve University
2020
Creative Commons
2019
Union Hospital
2019
Abstract 3D bioprinting techniques have enabled the fabrication of irregular large‐sized tissue engineering scaffolds. However, complicated customized designs increase medical burden. Meanwhile, integrated printing process hinders cellular uniform distribution and local angiogenesis. A novel approach is introduced to construction sizable grafts by employing hydrogel for modular bioadhesion assembly, a poly (ethylene glycol) diacrylate (PEGDA)‐gelatin‐dopamine (PGD) hydrogel, photosensitive...
Background: The efficacy of autologous fat transplantation is reduced by absorption and fibrosis that are closely related to unsatisfactory vascularization. Extracellular vesicles key components the cell secretome, which can mirror functional molecular characteristics their parental cells. Growing evidence has revealed adipose-derived mesenchymal stem cells have ability enhance vascularization, partly ascribed extracellular vesicles. authors evaluated whether cell–derived improved...
Graphene Oxide (GO)-related hydrogels have been extensively studied in hard tissue repair, because GO can not only enhance the mechanical properties of polymers but also promote osteogenic differentiation mesenchymal stem cells. However, simple GO-related are ideal for repair osteoporotic bone defects as overactive osteoclasts osteoporosis. Alendronate (Aln) is known to inhibit and may bind through covalent connection. Therefore, delivering Aln be effective defects. Here, we developed a...
The increasing demands for the management of hemostasis and tissue sealing drive development novel bioadhesives, which can overcome disadvantages conventional sutures such as additional damage, increased infection probability, body fluid/air leakage. Bioadhesives form a protective layer with seamless adhesion between injured tissues, thereby quickly closing wound creating appropriate microenvironments healing. In this review, recent advancement in bioadhesives made natural macromolecules...
The survival of transplanted cells and tissues in bone regeneration requires a microenvironment with vibrant vascular network. A tissue engineering chamber can provide this vivo. However, the commonly used silicone is biologically inert cause rejection reactions fibrous capsule. Studies have revealed that collagen highly biocompatible graphene oxide (GO) could regulate osteogenic activity Besides, GO be cross-linked natural biodegradable polymers to construct scaffolds. Methods: vascularized...
Breast tissue engineering is a promising alternative to standard treatments for breast defects. Although there consensus that the mechanical property of scaffold should best match reconstructed tissue, simulation soft and elastic tactility native tissues using conventional materials architecture design requires further study. Previous research has shown crystal microstructure-like can drastically alter properties constructed scaffolds. In this study, we designed additive manufactured four...
Background: Microtissues constructed with hydrogels promote cell expansion and specific differentiation by mimicking the microarchitecture of native tissues. However, suboptimal mechanical property osteogenic activity microtissues fabricated natural polymers need further improvement for bone reconstruction application. Core-shell designed structures are composed an inner core part outer shell, combining characteristics different materials, which improve microtissues. Methods: A micro-stencil...
Impaired wound healing might be associated with many issues, especially overactive of reactive oxygen species (ROS), deficiency blood vessels and immature epidermis. N-acetylcysteine (NAC), as an antioxidant, could solve these problems by inhibiting overreactive ROS, promoting revascularization accelerating re-epithelialization. How to deliver NAC in situ a controllable releasing speed still remain challenge.In this study, we combined collagen (Col) perform the characteristics sustained...
Abstract PCL (poly‐caprolactone) nanofibers have good biocompatibility and high porosity, which are usually utilized for application in wound dressings. However, healing could be hindered by the overproduction of reactive oxygen species (ROS) different factors. Pure cannot satisfy these requirements healing. N ‐acetylcysteine (NAC), as an antioxidant, meets resisting ROS promoting angiogenesis maturation epidermis. In this study, we prepared a sandwich structured PCL‐Col/NAC scaffold using...
Abstract Tissue engineering is a promising technology used as an alternative to organ/tissue transplantation which often limited by donor shortage. The construction of large-sized engineered tissue requires fast and sufficient vascularization process. Previous studies have shown that hypoxia-inducible factor (HIF) -1α may promote the process implying stabilized HIF-1α can be applied in tissue. However, toxicity off-target effect previously reported stabilizers limit their clinical...
ZIF-8 may experience ion-responsive degradation in ionic solutions, which will change its initial architecture and restrict direct biological use. Herein, we report an abnormal phenomenon induces large hydroxyapatite-like crystals when soaked directly simulated body fluid. These grew rapidly continuously for two weeks, with the volume increasing by over 10 folds. According to Zn2+ release novel XRD diffraction peak presence, particles can probably show gradual collapse became congregate...
Abstract Breast tissue engineering is a promising alternative to post‐mastectomy breast reconstruction. However, the high relapse rate (about 20%) of this malignant tumor negatively affects its long‐term prognosis. Moreover, shortage recipient site volume often hampers reconstruction large‐sized breast. Here, work reports on additive manufacturing novel scaffold with photothermal shape memory and ablation properties solve aforementioned issues. Graphene nanosheets (GN) are used functionalize...
Effective repair of full-thickness abdominal wall defects requires a patch with sufficient mechanical strength and anti-adhesion characteristics to avoid the formation hernias intra-abdominal complications such as intestinal obstruction fistula. However, patches made from polymers or bio-derived materials may not meet these requirements lack bionic wall.In this study, we report consecutive electrospun method for preparing double-layer structured nanofiber membrane (GO-PCL/CS-PCL) using...
Researches of biomaterials for osteoporotic bone defects focus on the improvement its anti-osteoporosis ability, due to osteoporosis is a kind systemic and long-range metabolism disorder. Nevertheless, how steadily deliver drugs in rarely studied. Reported evidences have shown that alendronate (Aln) known not only restrain osteoclasts from mediating resorption but also stimulate osteoblasts regenerate tissue. Here, we developed an engineered implantable scaffold could sustainably release Aln...
Abstract All‐liquid molding can be used to transform a liquid into free‐form solid constructs, while maintaining internal fluidity. Traditional biological scaffolds, such as cured pre‐gels, are normally processed in state, sacrificing flowability and permeability. However, it is essential maintain the fluidity of scaffold truly mimic complexity heterogeneity natural human tissues. Here, this work molds an aqueous biomaterial ink building blocks with rigid shapes preserving The molded for...
Delayed diabetic wound healing is one of the clinical difficulties, main reason limited angiogenesis ability. Deferriamine (DFO) an iron chelating agent that can induce angiogenesis, but its application due to short half-life. Increasing load and slow release performance desferriamine beneficial accelerate healing.
Background. Mesenchymal stromal cells (MSCs) and their secreted extracellular vesicles (MSC-EVs) possess similar proregenerative effects when injected into defects immediately following trauma. However, MSC-EVs are superior to MSCs in terms of storage rejection reflection, while immediate administration is related several target for most donor die within few weeks. Besides, the inflammatory cascade incited, providing an unfavorable environment cells. We hypothesized that delayed injection...