A5064784533- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Animal Behavior and Reproduction
- Renal and related cancers
- CRISPR and Genetic Engineering
- interferon and immune responses
- Wnt/β-catenin signaling in development and cancer
- Bacteriophages and microbial interactions
- Mobile Health and mHealth Applications
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Insect and Arachnid Ecology and Behavior
- Pharmaceutical Practices and Patient Outcomes
- Rheumatoid Arthritis Research and Therapies
- Biomarkers in Disease Mechanisms
- Computational Drug Discovery Methods
- Biosensors and Analytical Detection
- Neurobiology and Insect Physiology Research
- Medication Adherence and Compliance
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Biosimilars and Bioanalytical Methods
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Influenza Virus Research Studies
Indian Institute of Information Technology Allahabad
2016-2023
Boehringer Ingelheim (United States)
2023
University of Houston
2019
Novartis (India)
2018
Genome Institute of Singapore
2017
NYU Langone Health
2015
New York University
2011-2013
Banaras Hindu University
1989
The maintenance of pluripotency in mouse embryonic stem cells (mESCs) relies on the activity a transcriptional network that is fuelled by three transcription factors (Nanog, Oct4 and Sox2) balanced repressive Tcf3. Extracellular signals modulate regulate differentiation capacity cells. Wnt/β-catenin signaling has emerged as significant potentiator pluripotency: increases levels β-catenin Nanog, enhance pluripotency. A recent report shows achieves some these effects modulating Tcf3, this...
Regulatory networks driving morphogenesis of animal genitalia must integrate sexual identity and positional information. Although the genetic hierarchy that controls somatic in fly Drosophila melanogaster is well understood, there are very few cases which mechanism by it tissue-specific gene activity known. In flies, sex-determination terminates doublesex (dsx) gene, produces sex-specific transcription factors via alternative splicing its transcripts. To identify sex-specifically expressed...
The ability of mouse embryonic stem cells (mESCs) to self-renew or differentiate into various cell lineages is regulated by signaling pathways and a core pluripotency transcriptional network (PTN) comprising Nanog, Oct4, Sox2. Wnt/β-catenin pathway promotes alleviating T factor TCF3-mediated repression the PTN. However, it has remained unclear how β-catenin’s function as activator with TCF1 influences mESC fate. Here, we show that TCF1-mediated transcription up-regulated in differentiating...
Abstract The 2i-media, composed of two small molecule inhibitors (PD0325901 and CHIR99021) against MEK GSK3-kinases, respectively, is known to establish naïve ground state pluripotency in mouse embryonic stem cells (mESCs). These block MEK-mediated differentiation, while driving β-catenin dependent de-repression promoting targets. However, accumulating evidence suggest that β-catenin’s association with activating TCFs (TCF7 TCF7L2) can induce expression several lineage-specific...
While most studies emphasize on certain aspects of Pathogen-Host Interactions (PHI), such as the preferential attachment bacteria or virus to its human receptor homolog, have attempted methodically classify interactions among pathogenic proteins and their host proteins. Here we analyzed 182 pathogens from The Interaction Search Tool (PHISTO) [1] could identify proteins/protein coding genes that act both bacteria. Importantly there were few viz. P53 (Tumor protein p53), NFKB1 (Nuclear factor...
While most studies emphasize on certain aspects of Pathogen-Host Interactions (PHI), such as the preferential attachment bacteria or virus to its human receptor homolog, have attempted methodically classify interactions among pathogenic proteins and their host proteins. Here we analyzed 182 pathogens from The Interaction Search Tool (PHISTO) could identify proteins/protein coding genes that act both bacteria. Importantly there were few viz. P53 (Tumor protein p53), NFKB1 (Nuclear factor...
Various theoretical studies have been carried out to infer relevant protein-protein interactions among pathogens and their hosts. Such are generally based on preferential attachment of bacteria / virus human receptor homologs. We analyzed 17 pathogenic species mainly belonging bacterial viral classes, with the aim identify interacting proteins which targeted by both specifically. Our study reveals that TLRs play a crucial role between pathogen-associated molecular patterns (PAMPs) damage...
Decades of research on exosomes, nano-sized vesicles secreted by cells, have revealed novel roles these in the formation pre-metastasis niches that enhances migration tumor cells to those sites. Paradoxically, more recent work has suggested tumor-derived exosomes can also an immunostimulatory role, depending model studied. The rate secretion single is likely heterogeneous, and a deep profiling capacity individual been largely unexplored.We developed high-throughput single-cell methodology...