A5001327472- Cervical Cancer and HPV Research
- Genital Health and Disease
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Hepatitis B Virus Studies
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- Maternal and Perinatal Health Interventions
- Cancer-related molecular mechanisms research
- AI in cancer detection
Women's Hospital, School of Medicine, Zhejiang University
2012-2024
Zero to Three
2023
Background Deep learning has presented considerable potential and is gaining more importance in computer assisted diagnosis. As the gold standard for pathologically diagnosing cervical intraepithelial lesions invasive cancer, colposcopy-guided biopsy faces challenges improving accuracy efficiency worldwide, especially developing countries. To ease heavy burden of cancer screening, it urgent to establish a scientific, accurate efficient method assisting diagnosis biopsy. Methods The data were...
Abstract Background Cytology and high‐risk human papilloma virus (hrHPV) cotesting is the mainstay in detection of cervical carcinoma. Methods Endocervical adenocarcinoma (EAC) divided into HPV‐associated (HPVA) HPV‐independent (HPVI) by World Health Organization classification (2020). The effect suggested to be different among EAC subtypes precursors, but has not well‐documented yet. In this study, authors retrospectively analyzed situ (AIS), HPVA, HPVI. cohort included 569 AIS 498...
Tumor invasion and metastasis are the processes that primarily cause adverse outcomes in patients with cervical cancer. Cancer‑associated fibroblasts (CAFs), which participate cancer progression metastasis, novel targets for treatment of tumors. The present study aimed to assess heterogeneity CAFs microenvironment through single‑cell RNA sequencing. After collecting five samples obtaining CAF‑associated gene sets, were divided into myofibroblastic extracellular (ec)CAFs. ecCAFs appeared more...
Human papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics HPV infections, including genotype and duration infection, determine a patient's risk high-grade lesions. Risk quantification lesions caused by different genotypes an important component evaluation lesion. Data evidence are necessary to gain deeper understanding pathogenicity genotypes. The present study investigated clinical characteristics patients infected with single human 53.This retrospective...
This study aimed to better characterize the clinical and molecular features in invasive stratified mucin-producing carcinoma (ISMC), an uncommon aggressive subtype of endocervical adenocarcinoma (EAC).We recruited 59 ISMC for clinicopathological analysis, immunohistochemistry (n = 56), targeted next-generation sequencing 17). Our cases contained 29 pure 30 mixed-type ISMC. Five patients developed local recurrence at 6-32 months (median: 13 months), died disease 16-55 16 months). Pure showed...
Objective To investigate the application of admission test as a medical management in labor room.Methods Eight hundred and fifty singleton pregnant women underwent room at Women's Hospital,School Medicine,Zhejiang University from Dec.2009 to Dec.2011 were enrolled into this study.They divided two groups:normal group (admission was normal,n =658) abnormal or undetermined,n =192).Deliveries perinatal outcomes them observed.The difference between groups compared with independent sample t...