A5002661842- Cancer Treatment and Pharmacology
- Chromatography in Natural Products
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Photodynamic Therapy Research Studies
- Interactive and Immersive Displays
- Context-Aware Activity Recognition Systems
- Tactile and Sensory Interactions
- Cancer Immunotherapy and Biomarkers
- Multimedia Communication and Technology
Eisai (Japan)
2023
Tokyo University of Agriculture and Technology
1999
The University of Tokyo
1999
Abstract Eribulin is a microtubule dynamics inhibitor with tumor microenvironment modulation activity such as vascular remodeling activity. Here, we investigated antitumor and immunomodulatory activities of eribulin its liposomal formulation (eribulin-LF) monotherapies or in combination anti–programmed death 1 (PD-1) Ab. The eribulin-LF monotherapy anti–PD-1 Ab was examined P-glycoprotein–knockout 4T1 model. showed stronger immunocompetent mice compared immunodeficient mice, indicating that...
Our video demonstrates a new style of human interface with an interactive electronic whiteboard. Its design goal is to realize easy and natural operation large board from arbitrary standing position the user reasonable amount hand movement, no hiding by user's body. We have been attempting attain this smoothly naturally extending current desktop GUI rather than relying on unreliable gesture commands.
<p>Fig S1 shows isotype control has no antitumor activity. Fig S2 gating strategy for flow cytometric analysis of TILs. S3 induction ICAM-1 by eribulin. S4 establishment P-gp KO cell lines and ICD activity S5 dose-dependent eribulin-LF + anti-PD-1 Ab. S6 PK eribulin in plasma tumor. S7 immunomodulatory different 3 regimens. S8 TIL population changes not included the main figures. S9 activation IFN signature eribulin-LF.</p>
<p>Supplementary Materials and Methods not included in the main manuscript</p>
<p>Antibody lists used in the flow cytometric analysis</p>
<p>Legends for supplementary figures S1-S9</p>
<div>Abstract<p>Eribulin is a microtubule dynamics inhibitor with tumor microenvironment modulation activity such as vascular remodeling activity. Here, we investigated antitumor and immunomodulatory activities of eribulin its liposomal formulation (eribulin-LF) monotherapies or in combination anti–programmed death 1 (PD-1) Ab. The eribulin-LF monotherapy anti–PD-1 Ab was examined P-glycoprotein–knockout 4T1 model. Eribulin showed stronger immunocompetent mice compared...
<p>Fig S1 shows isotype control has no antitumor activity. Fig S2 gating strategy for flow cytometric analysis of TILs. S3 induction ICAM-1 by eribulin. S4 establishment P-gp KO cell lines and ICD activity S5 dose-dependent eribulin-LF + anti-PD-1 Ab. S6 PK eribulin in plasma tumor. S7 immunomodulatory different 3 regimens. S8 TIL population changes not included the main figures. S9 activation IFN signature eribulin-LF.</p>
<p>Legends for supplementary figures S1-S9</p>
<p>Antibody lists used in the flow cytometric analysis</p>
<p>Supplementary Materials and Methods not included in the main manuscript</p>
<div>Abstract<p>Eribulin is a microtubule dynamics inhibitor with tumor microenvironment modulation activity such as vascular remodeling activity. Here, we investigated antitumor and immunomodulatory activities of eribulin its liposomal formulation (eribulin-LF) monotherapies or in combination anti–programmed death 1 (PD-1) Ab. The eribulin-LF monotherapy anti–PD-1 Ab was examined P-glycoprotein–knockout 4T1 model. Eribulin showed stronger immunocompetent mice compared...
<p>Supplementary Materials and Methods not included in the main manuscript</p>
<p>Fig S1 shows isotype control has no antitumor activity. Fig S2 gating strategy for flow cytometric analysis of TILs. S3 induction ICAM-1 by eribulin. S4 establishment P-gp KO cell lines and ICD activity S5 dose-dependent eribulin-LF + anti-PD-1 Ab. S6 PK eribulin in plasma tumor. S7 immunomodulatory different 3 regimens. S8 TIL population changes not included the main figures. S9 activation IFN signature eribulin-LF.</p>
<p>Legends for supplementary figures S1-S9</p>
<p>Antibody lists used in the flow cytometric analysis</p>
<p>Legends for supplementary figures S1-S9</p>
<p>Supplementary Materials and Methods not included in the main manuscript</p>
<p>Antibody lists used in the flow cytometric analysis</p>
<p>Fig S1 shows isotype control has no antitumor activity. Fig S2 gating strategy for flow cytometric analysis of TILs. S3 induction ICAM-1 by eribulin. S4 establishment P-gp KO cell lines and ICD activity S5 dose-dependent eribulin-LF + anti-PD-1 Ab. S6 PK eribulin in plasma tumor. S7 immunomodulatory different 3 regimens. S8 TIL population changes not included the main figures. S9 activation IFN signature eribulin-LF.</p>
<div>Abstract<p>Eribulin is a microtubule dynamics inhibitor with tumor microenvironment modulation activity such as vascular remodeling activity. Here, we investigated antitumor and immunomodulatory activities of eribulin its liposomal formulation (eribulin-LF) monotherapies or in combination anti–programmed death 1 (PD-1) Ab. The eribulin-LF monotherapy anti–PD-1 Ab was examined P-glycoprotein–knockout 4T1 model. Eribulin showed stronger immunocompetent mice compared...
Our video demonstrates a new style of human interface with an interactive electronic whiteboard. Its design goal is to realize easy and natural operation large board from arbitrary standing position the user reasonable amount hand movement, no hiding by user's body. We have been attempting attain this smoothly naturally extending current desktop GUI rather than relying on unreliable gesture commands.