A5033154372- Computational Drug Discovery Methods
- Synthesis and biological activity
- Advanced oxidation water treatment
- Click Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Multicomponent Synthesis of Heterocycles
- Asymmetric Hydrogenation and Catalysis
- Water Quality Monitoring and Analysis
- Municipal Solid Waste Management
- Water Quality and Pollution Assessment
- Catalytic Cross-Coupling Reactions
- Wastewater Treatment and Reuse
- Advanced Photocatalysis Techniques
- Cholinesterase and Neurodegenerative Diseases
- Fuel Cells and Related Materials
- Graphene and Nanomaterials Applications
- Nanomaterials for catalytic reactions
- Oxidative Organic Chemistry Reactions
- Cancer therapeutics and mechanisms
- Diverse Scientific Research Studies
- Arsenic contamination and mitigation
- Botanical Research and Applications
- Mine drainage and remediation techniques
- Biomedical Research and Pathophysiology
- Chromium effects and bioremediation
Sidi Mohamed Ben Abdellah University
1998-2025
Laboratoire de Chimie Physique
1998-2020
Agence pour le Développement et la Réhabilitation de la Ville de Fès
2017-2018
Laboratoire de Chimie
2015-2018
Université Moulay Ismail de Meknes
2017
Mohamed I University
2015
Hôpital Tenon
2012
Sorbonne Université
2012
SAIT Polytechnic
2008-2010
Centre Hospitalier Ibn Sina
2010
Breast cancer is the most frequent form of malignant tumor in women, and represents a major public health problem due to its high mortality rate. Although multitude therapeutic options exist for control this disease, emergence resistance current pharmaceutical treatments underscores urgency developing new anti- breast drugs, with focus on reducing adverse effects associated agents. The present study concerns series (23) compounds based 1,4-quinone quinoline derivatives design candidate drugs...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRates and mechanisms of oxidative addition to zerovalent palladium complexes generated in situ from mixtures Pd0(dba)2 triphenylphosphineChristian Amatore, Anny Jutand, Fouad Khalil, Mohamed A. M'Barki, Loic MottierCite this: Organometallics 1993, 12, 8, 3168–3178Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://doi.org/10.1021/om00032a045RIGHTS & PERMISSIONSArticle...
Mixtures of Pd(dba)2 + 2L-L (where L-L is a bidentate ligand such as dppm, dppe, dppp, dppb, dppf, and DIOP) lead to the formation Pd(L-L)2 complexes which do not undergo an oxidative addition with phenyl iodide. 2 BINAP afford Pd(BINAP)2 but Pd(dba)(BINAP). 1L-L (L-L = DIOP, BINAP) Pd(dba)(L-L) via formation, at short time, complex Pd(L-L)2, except for dppf where directly formed. main in solution involved endergonic equilibrium less ligated Pd(L-L) dba. more reactive species However, also...
Cervical cancer is a major health problem of women. Hormone therapy, via aromatase inhibition, has been proposed as promising way blocking estrogen production well treating the progression estrogen-dependent cancer. To overcome challenging complexities costly drug design, in-silico strategy, integrating Structure-Based Drug Design (SBDD) and Ligand-Based (LBDD), was applied to large representative databases 39 quinazoline thioquinazolinone compound derivatives. Quantum chemical...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon dioxide as a C1 building block. Mechanism of palladium-catalyzed carboxylation aromatic halidesChristian Amatore, Anny Jutand, Fouad Khalil, and Merete F. NielsenCite this: J. Am. Chem. Soc. 1992, 114, 18, 7076–7085Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/ja00044a018https://doi.org/10.1021/ja00044a018research-articleACS...
Unsaturated ketone derivatives are known as inhibitors of monoamine oxidase B (MAO-B), a potential drug target Parkinson's disease. Here, docking-based alignment, 3 D-QSAR (three-dimensional quantitative structure-activity relationship) studies, ADMET (absorption, distribution, metabolism, excretion, and toxicity) prediction, molecular dynamics (MD) simulation, MM_GBSA binding free energy were performed on novel series MAO-B inhibitors. The objective is to predict new with high potency...
Herein, we investigate how to improve the hydrochar yield via hydrothermal carbonization process, focusing on use of almond shells as a carbon resource. We have employed various modeling techniques, including response surface methodology, artificial neural networks, support vector machines and XGBoost, determine optimal conditions for maximizing yield. The results highlight excellent performance ANN XGBoost models, with high R² values lower RMSE values, while SVM model offers insights into...
A comprehensive treatment approach for tannery effluent (TE) was investigated using an integral system involving coagulation–flocculation (CF) as a pre-treatment before the ultrasound combined with photo-Fenton process (US-PFP). The by CF 2 g/l of FeCl 3 resulted in chemical oxidation demand (COD), turbidity, and colour number (CN) removal efficiencies 56%, 99%, 85%, respectively. efficiency US-PFP statistically evaluated, optimal operating conditions were determined Box–Behnken Design....
Breast cancer has been one of the most challenging women's cancers and leading cause mortality for decades. There are several studies being conducted all time to find a cure breast cancer. Quinoline derivatives have shown their potential as antitumor agents in therapy. In this work, three-dimensional quantitative structure-activity relationships (3D-QSAR) molecular docking with aromatase enzyme (Protein Data Bank: 3S7S) were performed suggest current scenario quinoline refine path these...
For PPh3, mixtures of Pd(dba)2 and nTFP (TFP = tri-2-furylphosphine, n ≥ 2) in DMF THF (S) lead to the formation Pd(dba)(TFP)2, SPd(TFP)3 equilibrium with SPd(TFP)2. The substitution dba by phosphine Pd(dba)L2 form SPdL3 is easier for L TPF than PPh3. less ligated complex SPd(TFP)2 reactive species oxidative addition phenyl iodide. In THF, {Pd(dba)2 + nTFP}, a mixture often used as catalyst promoter several synthetic organic reactions, found be nPPh3} small values (n 2 or 4) whereas it more...
This article presents a combination of coagulation-flocculation and powder activated carbon (PAC) adsorption as treatment process for landfill leachate.Leachates were collected from municipal solid waste in Mediouna site, Casablanca city.Ferric chloride (FeCl 3 ) is used here coagulant to study the optimum conditions removal chemical oxygen demand (COD), colour, total suspended solids (TSS) turbidity jar tests.This showed highest efficiency terms COD (62.5%), (92.5%), colour (80%) least...