A5103041426- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- RNA modifications and cancer
- Intraperitoneal and Appendiceal Malignancies
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Gastroesophageal reflux and treatments
- Appendicitis Diagnosis and Management
- Pelvic floor disorders treatments
- RNA regulation and disease
- Intestinal and Peritoneal Adhesions
- Respiratory Support and Mechanisms
University of Oxford
2024
Oxford University Hospitals NHS Trust
2024
NIHR Southampton Biomedical Research Centre
2023
University Hospital Southampton NHS Foundation Trust
2023
University of Cambridge
2019-2020
Abstract Membraneless organelles are sites for RNA biology including small non-coding (ncRNA) mediated gene silencing. How ncRNAs utilise phase separated environments their function is unclear. We investigated how the PIWI-interacting (piRNA) pathway engages with membraneless organelle P granule in Caenorhabditis elegans . Proteomic analysis of PIWI protein PRG-1 reveals an interaction constitutive DEPS-1. DEPS-1 not required piRNA biogenesis but piRNA-dependent silencing: deps-1 mutants...
Summary Membraneless organelles are platforms for many aspects of RNA biology including small non-coding (ncRNA) mediated gene silencing. How ncRNAs utilise phase separated environments their function is unclear. To address this question, we investigated how the PIWI-interacting (piRNA) pathway engages with membraneless organelle P granule in Caenorhabditis elegans . Proteomic analysis PIWI protein PRG-1 revealed an interaction constitutive DEPS-1. Furthermore identified a novel motif on...